Expression analysis of Wnt signaling pathway related lncRNAs in periodontitis: A pilot case-control study

Ghafouri‐Fard, Soudeh; Dashti, Sepideh; Gholami, Leila; Badrlou, Elham; Sadeghpour, Saba; Hussen, Bashdar Mahmud; Hidayat, Hazha Jamal; Nazer, Naghme; Shadnoush, Mahdi; Sayad, Arezou; Arefian, Noormohammad

doi:10.1016/j.humgen.2022.201069

Cited by 1 publication

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“…For example, the lncRNA POIR acts as a sponge for miR-182, which binds to the 3’ UTR of FOXO1. FOXO1 inhibits the canonical Wnt signaling pathway, suggesting that POIR lncRNA may regulate Wnt signaling in periodontitis [ 94 , 95 ]. Moreover, the overexpression of the lncRNA OIP5-AS1 is thought to inhibit the lipopolysaccharide (LPS)-induced inflammatory response in human periodontal ligament stem cells (PDLSCs) by sponging miR-92a-3p, which likely involves the NF-κB pathway [ 96 ].…”

Section: Introductionmentioning

confidence: 99%

The Expression Patterns of Non-Coding RNAs in Periodontal Disease

Adamouli,

Marasli,

Bobetsis

2024

Dentistry Journal

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During the last few decades there has been a growing interest in understanding the involvement of epigenetics in the pathogenesis and treatment of periodontal disease. Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), may serve as epigenetic modifiers affecting the expression of genes involved in the pathogenesis of inflammatory and autoimmune diseases. There is increasing evidence supporting the idea that the function of all three types of ncRNAs seems to be interdependent. LncRNAs can act as miRNA decoys, while circRNAs can act as miRNA sponges, leading to the re-expression of miRNA target genes. The purpose of this review is to evaluate the expression patterns of ncRNAs in periodontal disease. Studies demonstrate a positive correlation between miRNA expression and periodontitis; however, this cannot be claimed for lncRNAs and circRNAs, which appear to be differentially expressed in periodontitis patients. Several studies have also suggested utilizing ncRNAs as diagnostic and prognostic biomarkers in periodontitis, or even as potential therapeutic targets; Nevetheless, the evidence to support this is premature. Future well-designed research remains necessary to establish the functional role of ncRNAs in the evolution and progression of periodontal disease.

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Section: Introductionmentioning

confidence: 99%