Expression and androgen regulation of the ciliary neurotrophic factor receptor (CNTFR?) in muscles and spinal cord

Xu, Jun; Forger, Nancy G.

doi:10.1002/(sici)1097-4695(199805)35:2<217::aid-neu8>3.0.co;2-7

Cited by 20 publications

(8 citation statements)

References 49 publications

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“…Moreover, mice with a null mutation in the ␣-subunit of CNTF receptor (CNTFR-␣) are not sexually dimorphic in the SNB, suggesting that the androgen-induced development of the sexual dimorphism requires the CNTFR-␣ (Forger et al, 1997). In addition, androgens regulate expression of CNTFR-␣ in the BC/LA and SNB at various times of life Xu and Forger, 1998). The present study indicates that androgens also interact with BDNF in regulation of SNB morphology and function, and leaves open the possibility that androgens and other protein trophic factors interact in their trophic effects on SNB development and function in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons

Yang

Arnold

2000

J. Neurobiol.

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In androgen‐sensitive motoneurons of the spinal nucleus of the bulbocavernosus (SNB), we investigated the interaction of BDNF (brain‐derived neurotrophic factor) and testosterone to understand whether each factor gates the ability of the other to regulate androgen receptor expression and soma size, and whether each factor requires the presence of the other for its action. We axotomized SNB motoneurons and applied BDNF or PBS (phosphate‐buffered saline) to the cut ends of the axons in rats that were castrated and treated with either testosterone or placebo. Control groups were either not castrated or not axotomized, or had intact SNB axons and were castrated and treated with testosterone or placebo. We found that testosterone determined the expression of nuclear androgen receptor, and this effect was enhanced by both BDNF and contact with the target muscles. The effect of BDNF on androgen receptor expression was seen only when testosterone was present. In the regulation of soma size, BDNF dominated. The application of BDNF completely compensated for the loss of testosterone in castrated males so that the testosterone effect on soma size was seen only in intact SNB motoneurons and in axotomized motoneurons treated with PBS. Moreover, testosterone increased androgen receptor and soma size in axotomized SNB motoneurons, indicating that testosterone can act on sites other than the target muscles of the SNB to regulate each of these. These results indicate that the regulation of androgen receptor by testosterone does not require BDNF, but the regulation of androgen receptor by BDNF does require testosterone. The regulation of soma size by BDNF does not require high expression of nuclear androgen receptor. © 2000 John Wiley & Sons, Inc. J Neurobiol 44: 308–319, 2000

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Section: Discussionmentioning

confidence: 99%

Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons

Yang

Arnold

2000

J. Neurobiol.

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“…It has been suggested that membrane-bound and soluble CNTFR might differ in some of their binding characteristics (27) and it is possible this might contribute to the difference in the hypothalamic and pituitary actions of CNTF. CNTFR-a mRNA expression has been demonstrated to be sex hormone dependent (28) and the targeted disruption of CNTFR-a, in the knockout mouse, results in loss of sexual dimorphism in spinal cord architecture (29). This suggests that the effects of CNTF are both dependent on and may mediate some of the actions of sex steroids.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Ciliary Neurotrophic Factor on the Hypothalamo‐Pituitary Gonadal Axis In Vitro in Female Rats

Stanley¹,

Todd²,

Small³

et al. 2000

J Neuroendocrinology

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Ciliary neurotrophic factor (CNTF) is a member of the neuropoietic family of cytokines. CNTF exerts its actions through activation of a receptor complex, which shows similarity of sequence, second messenger systems and distribution to the leptin receptor. Leptin has been demonstrated to exert profound effects on the hypothalamo-pituitary gonadal axis. This study examines the in vitro effects of CNTF on hypothalamic luteinizing hormone releasing hormone release (LHRH) and pituitary luteinizing hormone (LH) release compared to those of leptin in the female. We report that CNTF stimulates LHRH release from medial basal hypothalamic explants harvested from proestrous female rats and this effect is of similar magnitude to that seen with leptin. In contrast, CNTF suppresses LHRH-stimulated LH release from dispersed anterior pituitary cells harvested from proestrous female rats but has no effect on basal LH release. Leptin stimulates basal LH release but has no effect on LHRH-stimulated LH release. The suppressive effect of CNTF on LHRH-stimulated LH release has been confirmed in perifused anterior hemipituitaries. These results suggest a differential effect of CNTF on the hypothalamo-pituitary gonadal axis and a possible role in the modulation of pituitary gonadal function.

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“…On the other hand, many reports came from studies related to CNTF and body composition and it is reported that CNTF affects weight by the activation of intracellular signaling pathways (janus kinases and signal transducers and activators of transcription 3, JAK/STAT3) such as leptin in hypothalamic nuclei which controls appetite and weight and also it is related to anorexia and weight reduction [24,25]. …”

Section: Discussionmentioning

confidence: 99%

Effects of detraining on motor unit potential area, muscle function and physical performance based on CNTF gene polymorphism

Hong

Shin

2014

Journal of Exercise Nutrition and Biochemistry

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[Purpose]The purpose of this study was to identify the effect of detraining on motor unit potential area (SMUP), muscular function and physical performance, according to CNTF gene polymorphism.[Methods]For this study, GG (normal homozygote, n = 8) group and GA + AA (mutation heterozygote and homozygote, n = 10) group were divided by CNTF gene polymorphism and both groups were performed detraining for 4 weeks. The data was analyzed by two-way repeated measures ANOVA for verifying the differences between two groups and interaction using SPSS (ver. 20.0) statistical program.[Results]The results were as follows. First, changes in body composition were measured but there was no significant interaction effect between time and group. Seconds, changes in SMUP were measured by SEMG. Interaction effect between time and group was found lateral vastus during isokinetic exercise of 180°/sec (p < .05). Third, changes in isokinetic muscle strength of 60°/sec and 180°/sec were measured but there was no significant interaction effect. Fourth, significant statistical differences were not showed changes of sports performance after detraining.[Conclusion]In conclusion, there were no significantly differences between GG and GA + AA group after detraining, therefore, further study will be considered a matter in various its interventions such as serum levels of CNTF and changes in receptors and muscle fiber types.

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Expression and androgen regulation of the ciliary neurotrophic factor receptor (CNTFR?) in muscles and spinal cord

Cited by 20 publications

References 49 publications

Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons

Interaction of BDNF and testosterone in the regulation of adult perineal motoneurons

The Effects of Ciliary Neurotrophic Factor on the Hypothalamo‐Pituitary Gonadal Axis In Vitro in Female Rats

Effects of detraining on motor unit potential area, muscle function and physical performance based on CNTF gene polymorphism

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