Expression and characterization of the JAK kinase and STAT protein from brine shrimp, Artemia franciscana☆

Cheng, Chia Hsiung; Chen, Gen Der; Yeh, Maw Sheng; Chu, Cheng Ying; Hsu, Yu‐Chin; Hwang, Pung Pung; Huang, Fore‐Lien; Huang, Chang Jen

doi:10.1016/j.fsi.2010.01.022

Cited by 25 publications

(12 citation statements)

References 34 publications

(65 reference statements)

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“…In crustacean, several STAT proteins have been isolated from L. vannamei [17], F. chinensis [18], P. monodon [19], M. japonicas [20] and A. franciscana [16]. However, there is only a Janus Kinase from A. franciscana functionally identified in crustacea.…”

Section: Discussionmentioning

confidence: 99%

“…However, less is known about the roles of the JAK/STAT pathway during the immune response of shrimps against pathogens. In crustacean, the Artemia franciscana JAK is the only JAK gene that has been reported [16]. But several STAT genes were studied in other species such as A. franciscana [16], L. vannamei [17], Fenneropenaeus chinensis [18], Penaeus monodon [19] and Marsupenaeus japonicas [20].…”

Section: Introductionmentioning

confidence: 99%

“…In crustacean, the Artemia franciscana JAK is the only JAK gene that has been reported [16]. But several STAT genes were studied in other species such as A. franciscana [16], L. vannamei [17], Fenneropenaeus chinensis [18], Penaeus monodon [19] and Marsupenaeus japonicas [20]. In this study, a JAK gene was cloned from L. vannamei (named as LvJAK), and its mRNA expression and potential functions were examined during white spot syndrome virus (WSSV) infection.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A Janus Kinase in the JAK/STAT signaling pathway from Litopenaeus vannamei is involved in antiviral immune response

Song

Zhang

Wang

et al. 2015

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Janus Kinase in the JAK/STAT signaling pathway from Litopenaeus vannamei is involved in antiviral immune response

Song

Zhang

Wang

et al. 2015

Fish & Shellfish Immunology

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“…In mammals and other vertebrates, JAK-STAT pathway plays a crucial function in lots of biological processes of both innate and adaptive immunity, such as apoptosis, proliferation, differentiation, hematopoiesis, oncogenesis and immune defense [39], [43]. However, in crustaceans, only the antibacterial or antiviral activities of several JAK/STAT genes are known so far [37], [44], [45]. It is still unknown whether the pathway has other functions and needs us to do more efforts for its complete function research.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Analysis and Discovery of Genes Involved in Immune Pathways from Hepatopancreas of Microbial Challenged Mitten Crab Eriocheir sinensis

Cui

Liu

et al. 2013

PLoS ONE

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BackgroundThe Chinese mitten crab Eriocheir sinensis is an important economic crustacean and has been seriously attacked by various diseases, which requires more and more information for immune relevant genes on genome background. Recently, high-throughput RNA sequencing (RNA-seq) technology provides a powerful and efficient method for transcript analysis and immune gene discovery.Methods/Principal FindingsA cDNA library from hepatopancreas of E. sinensis challenged by a mixture of three pathogen strains (Gram-positive bacteria Micrococcus luteus, Gram-negative bacteria Vibrio alginolyticus and fungi Pichia pastoris; 108 cfu·mL−1) was constructed and randomly sequenced using Illumina technique. Totally 39.76 million clean reads were assembled to 70,300 unigenes. After ruling out short-length and low-quality sequences, 52,074 non-redundant unigenes were compared to public databases for homology searching and 17,617 of them showed high similarity to sequences in NCBI non-redundant protein (Nr) database. For function classification and pathway assignment, 18,734 (36.00%) unigenes were categorized to three Gene Ontology (GO) categories, 12,243 (23.51%) were classified to 25 Clusters of Orthologous Groups (COG), and 8,983 (17.25%) were assigned to six Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Potentially, 24, 14, 47 and 132 unigenes were characterized to be involved in Toll, IMD, JAK-STAT and MAPK pathways, respectively.Conclusions/SignificanceThis is the first systematical transcriptome analysis of components relating to innate immune pathways in E. sinensis. Functional genes and putative pathways identified here will contribute to better understand immune system and prevent various diseases in crab.

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“…However, when re-challenged 3 months after immune priming, the immune primed shrimp died at a rate similar to the control shrimp, suggesting that the protective mechanism chinensis [104]. JAK and STAT have also both been identified in the Brine shrimp, Artemia franciscana [105]. In P. monodon, WSSV has been shown to activate STAT [102,103].…”

Section: Protection Against Wssv Challenge Was First Demonstratedmentioning

confidence: 99%

Antiviral immunity and protection in penaeid shrimp

Underwood¹,

Cowley²,

Johnson

2013

Invertebrate Immunity

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The global aquaculture of penaeid shrimp has recently undergone a huge expansion resulting in production near parity with quantities trawled from the wild. Despite this apparent success, the industry has been hindered by diseases, predominantly from virus infection, which result in losses that have been estimated at 40% of the global production capacity. An increased research focus on penaeid immune response to virus infection has ensued, with an emphasis on harnessing the immune system to protect cultured shrimp from virus infection. Here we review the current knowledge of the factors implicated in the penaeid shrimp immune response to viral infection and strategies based on these discoveries that have been examined as potential avenues for disease control. Immune priming has been observed in response to challenge with White spot syndrome virus following prior exposure to virus or viral components. We review the protection achieved following immune priming with these components, the specificity and duration as well as the generality of the response and discuss potential mechanisms that may facilitate immune priming. In addition we highlight challenges associated with future research directions.

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Expression and characterization of the JAK kinase and STAT protein from brine shrimp, Artemia franciscana☆

Cited by 25 publications

References 34 publications

A Janus Kinase in the JAK/STAT signaling pathway from Litopenaeus vannamei is involved in antiviral immune response

A Janus Kinase in the JAK/STAT signaling pathway from Litopenaeus vannamei is involved in antiviral immune response

Transcriptome Analysis and Discovery of Genes Involved in Immune Pathways from Hepatopancreas of Microbial Challenged Mitten Crab Eriocheir sinensis

Antiviral immunity and protection in penaeid shrimp

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