Expression and clinical significance of UBE2V1 in cervical cancer

Abstract

The majority of cervical cancer (CC) patients are caused by the high-risk human papillomavirus (HPV) infection Although they are preventable and controllable, the mortality rate is still high. It is essential to identify the biomarkers for early screening and diagnosis of CC to improve the prognosis of patients with CC. The conjugating enzyme 2 (E2) family members are the key components of ubiquitin protease system. However, the role of E2 family in CC remains unclear. We aimed to investigate the role of UBE2V1 , a ubiquitin binding E2 enzyme variant protein (ube2v) without conserved cysteine residues required for E2s catalytic activity in CC. In this study, we first studied the expression of UBE2V1 in CC by real time quantitative PCR (RT-qPCR), and then, the clinical information of 191 CC patients in TCGA database was retrieved to explore the relationship between the expression of UBE2V1 and the occurrence and development of CC by examining the translational profile and methylation, the high expression of UBE2V1 was well correlated to the poor prognosis of patients, indicating that UBE2V1 is an independent risk factor for the prognosis of CC patients. The expression of UBE2V1 was also correlated with clinical stages, tumor grades and TNM stages of CC. In addition, the expression of UBE2V1 was slightly negatively correlated with the methylation at the multiple methylation sites. our study revealed the relationship between UBE2V1 and the occurrence and development of CC from the level of transcriptional profile and DNA methylation. UBE2V1 is a novel candidate biomarker for the diagnosis, screening and prognosis of CC.

Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis

“…UBE2V1 plays an important role in protein aggregate formation, study indicated that inhibition of UBE2V1 may provide a novel therapeutic target to treat cardiac proteinopathies [ 37 ]. In addition, UBE2V1 of aqueous humor expressed in the patients with Retinoblastoma (RB) [ 38 ], similarly, high expression of UBE2V1 was correlated to the poor prognosis of patients with cervical cancer [ 39 ]. The role of UBE2V1 in skin disease is unfamiliar, accordingly, UBE2V1 enables cellular responses toward fibroblast growth factor signaling in endothelium, acts as a key modulator for angiogenesis [ 40 ].…”

Clinicopathological significance and prognostic implications of Ube2v1 expression in colorectal cancer

“…Ubiquitin-conjugating enzyme E2 variant 1 (Ube2v1), also known as Uev1a, is a mammalian homolog of yeast MMS2 and an auxiliary factor of the ubiquitin-conjugating enzyme, Ube2n (10). Ube2v1 is a unique sub-member of the E2 family as it lacks the conserved catalytic cysteine in E2 (11). Ube2v1 complexes with Ube2n and activates the nuclear factor κB (NF-κB) signaling pathway, which is involved in the regulation of cancer (12).…”