Expression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer

Sevinc, Elif Demirdogen; Çeçener, Gülşah; Ak, Seçil; Tunca, Berrin; Egelí, Ünal; Gökgöz, Şehsuvar; Tolunay, Şahsine; Taşdelen, İsmet

doi:10.1016/j.gene.2016.05.033

Cited by 7 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings were consistent with ours. miRNA‐668 might play a role of oncogene and could be associated with radioresistance in breast cancer . In our study, similar results were found and showed that miRNA‐668 was a risk gene in GC.…”

Section: Discussionsupporting

confidence: 89%

A six‐microRNA signature to predict outcomes of patients with gastric cancer

Chen

Wang

et al. 2019

FEBS Open Bio

View full text Add to dashboard Cite

Gastric cancer ( GC ) is a common gastrointestinal tumor with poor prognosis. However, conventional prognostic factors cannot accurately predict the outcomes of GC patients. Therefore, there remains a need to identify novel predictive markers to improve prognosis. In this study, we obtained micro RNA expression profiles of 385 GC patients from The Cancer Genome Atlas. We performed Cox regression analysis to identify overall survival‐related micro RNA and then constructed a micro RNA signature‐based prognostic model. The accuracy of the model was evaluated and validated through Kaplan–Meier survival analysis and time‐dependent receiver operating characteristic ( ROC ) curve analysis. The independent prognostic value of the model was assessed by multivariate Cox regression analysis. Enrichment analysis was performed to explore potential functions of the prognostic micro RNA . Finally, a prognostic model based on a six‐micro RNA (mi RNA ‐100, mi RNA ‐374a, mi RNA ‐509‐3, mi RNA ‐668, mi RNA ‐549, and mi RNA ‐653) signature was developed. Further analysis in the training, test, and complete The Cancer Genome Atlas set showed the model can distinguish between high‐risk and low‐risk patients and predict 3‐year and 5‐year survival. The six‐micro RNA signature was also an independent prognostic marker, and enrichment analysis suggested that the micro RNA may be involved in cell cycle and mitosis. These results demonstrated that the model based on the six‐micro RNA signature can be used to accurately predict the prognosis of GC patients.

show abstract

Section: Discussionsupporting

confidence: 89%

A six‐microRNA signature to predict outcomes of patients with gastric cancer

Chen

Wang

et al. 2019

FEBS Open Bio

View full text Add to dashboard Cite

show abstract

“…Meanwhile, it is oncogenic in renal cell carcinoma, which denotes malignant cellular processes and worse prognosis [28]. In breast cancer, miR-663a is downregulated based on prior research [24]. Herein, we first portrayed that miR-663a was evidently inhibited in TNBC cell lines.…”

Section: Discussionmentioning

confidence: 98%

“…MiR-663a was characterized as a tumor-implicated miRNA including breast malignancy [22][23][24]. Thus, we probed its involvement in TNBC.…”

Section: Mir-663a Exerted Anti-growth Property In Tnbcmentioning

confidence: 99%

FOXC1-induced LINC01123 acts as a mediator in triple negative breast cancer

et al. 2020

View full text Add to dashboard Cite

Background: MicroRNAs (miRNAs) representing a subclass of non-coding RNAs are dynamically expressed and participate in multiple pathological responses, whereas, the expression pattern or function of miRNAs has not been fully addressed in triple-negative breast cancer (TNBC). Currently we concentrate on dissecting the probable role of microRNA-663a (miR-663a) in TNBC cellular processes. Methods: qRT-PCR detected the expression of miR-663a in TNBC cells. Besides, we monitored the effects of miR-663a on TNBC proliferation and apoptosis. On the basis of bioinformatics assistance and mechanical validation, we identified the miRNA-sponging role of LINC01123 and downstream target of miR-663a in TNBC was assessed and verified. The transcription activation of was explored via ChIP and luciferase reporter assays. Results: In comparison to MCF-10A, we certified the downregulation of miR-663a in TNBC cell lines. Augmentation of miR-663a was anti-proliferation and pro-apoptosis in TNBC cell lines. LINC01123 protected CMIP against miR-663a suppression through acting as a sponge of miR-663a in TNBC. LINC01123 was transcriptionally induced by FOXC1. Rescue experiment proved that miR-663a suppression or CMIP (c-Maf inducing protein) enhancement could countervail LINC01123 depletion-mediated effects on TNBC cellular processes. Conclusion: LINC01123, activated by FOXC1, regulated TNBC growth through miR-663a/CMIP signaling, which unveiled a new functional pathway of FOXC1-induced LINC01123/miR-663a/CMIP in TNBC.

show abstract

“…In addition, Zhao et al showed that miR‐922 is involved in the pathogenesis of Alzheimer's disease by regulating the level of UCHL1 to increase the level of phosphorylated tau . In cancer, Sevinc et al demonstrated that miR‐922 was also abnormally expressed in breast cancer, which was closely associated to the clinicopathological features of the patients . Furthermore, Liu et al reported that miR‐922 level was markedly increased in HCC.…”

Section: Discussionmentioning

confidence: 99%

“…miR‐922 is considered to be a tumor‐promoting gene, which can promote the occurrence and progress of tumor. Studies have shown that miR‐922 promotes a variety of diseases, such as liver cancer, breast cancer, and Alzheimer's disease . However, the role of miR‐922 on GC has not been revealed.…”

Section: Introductionmentioning

confidence: 99%

miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer

Shayimu¹,

Wang

Liu³

et al. 2019

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

Gastric cancer (GC) is the second leading cause of cancer‐related death worldwide. Studies have shown that miR‐922 facilitates the development of various diseases and tumors. However, the role of miR‐922 in GC and related molecular mechanisms are still unrevealed. Current study indicated that miR‐922 was overexpressed in GC tissues and cells. The survival rate of patients in high miR‐922 expression group is significantly lower than that in low miR‐922 expression group. In addition, overexpression of miR‐922 observably restrained the apoptosis of SGC7901 cells and promoted SGC7901 cell proliferation, migration, and invasion. TargetScan predicted that suppressors of cytokine signaling 1 (SOCS1) was a potential target of miR‐922. miR‐922 upregulation profoundly inhibited the expression of SOCS1. Furthermore, the mRNA level of SOCS1 in GC tissues was significantly lower than that in adjacent tissues, indicating that miR‐922 promoted the proliferation, invasion, and migration, and inhibited apoptosis of SGC7901 cells by downregulating the level of SOCS1. In conclusion, miR‐922 may have potential for diagnosis of GC.

show abstract

Expression and clinical significance of miRNAs that may be associated with the FHIT gene in breast cancer

Cited by 7 publications

References 29 publications

A six‐microRNA signature to predict outcomes of patients with gastric cancer

A six‐microRNA signature to predict outcomes of patients with gastric cancer

FOXC1-induced LINC01123 acts as a mediator in triple negative breast cancer

miR‐922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer

Contact Info

Product

Resources

About