Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer

Wang, Zhigang; Wang, Zheng; Zhu, Lei; Liu, Jikuan; Shi, Weicheng; Bai, Peiru; Lin, Xiaohui; Magaye, Ruth; Zhao, Jinshun

doi:10.2147/ott.s51997

Cited by 25 publications

(19 citation statements)

References 16 publications

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“…The IGFR signaling pathway regulates cell growth and development, which is essential for normal lung development and growth [19,20]. As a multifunctional protein receptor, IGF2R can bind IGF2 at the cell surface and regulates the IGFR signaling pathway [21].…”

Section: Discussionmentioning

confidence: 99%

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IGF2R Expression is Associated with the Chemotherapy Response and Prognosis of Patients with Advanced NSCLC

Tian¹,

Yao²,

Song³

et al. 2014

Cell Physiol Biochem

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Background: Insulin-like growth factor (IGF) pathway has been suggested as a new molecular target for the treatment of cancer including Non-small cell lung cancer (NSCLC). We postulated that IGF-2 receptor (IGF2R) may be associated with treatment response and prognosis of NSCLC patients receiving chemotherapy. Methods: A total of 464 patients with inoperable advanced stage of NSCLC were enrolled. All patients received platinum-based chemotherapy. Meanwhile, the IGF2R expression in tumor samples was detected by Immunohistochemical analysis. The IGF2R expression was inhibited in several human NSCLC cell lines (H292, A549, NCI-H460, Calu-3 and NCI-H23) after small interfering RNA (siRNA) transfection and the cellular biology behavior were evaluated. Results: Of all NSCLC patients, 204 had high IGF2R expression and 260 had low IGF2R expression. The low IGF2R expression was significantly associated with the smoking status, higher tumor stage, and poorer differentiation status of these patients. Notably, we found that the low IGF2R expression was closely associated with the chemotherapy response in NSCLC patients. Patients with low IGF2R expressions had a poorer prognosis than those with high IGF2R expressions. IGF2R inhibition by si-RNA technique in NSCLC cell lines increased the proliferation, migration and invasion abilities, but reduced the apoptosis rate. IGF2R silencing significantly enhanced the chemo-resistance of NSCLC cell lines to cisplatin treatment. Conclusion: The IGF2R expression in tumor is associated with the chemotherapy response and prognosis of Patients with advanced NSCLC.

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Section: Discussionmentioning

confidence: 99%

“…The staging system we used was the 7th edition of the TNM system [20]. All patients had received platinum-based chemotherapy after diagnosis and did not receive surgical treatment (Table 1).…”

Section: Methodsmentioning

confidence: 99%

IGF2R Expression is Associated with the Chemotherapy Response and Prognosis of Patients with Advanced NSCLC

Tian¹,

Yao²,

Song³

et al. 2014

Cell Physiol Biochem

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“…In gastric cancer, transcripts for several collagens, including COLA11A1, are also up-regulated in malignant compared to pre-malignant tumors 28 and COLA11A1 is also up-regulated in cancer-associated fibroblasts of colon adenocarcinomas. 29 Insulin-like Growth Factor 1 (IGF1) is a key player in NSCLC tumorigenesis and metastasis, 30 initiating cell signaling, promoting mitosis, proliferation and differentiation, and inhibiting apoptosis. HBP1 is a transcriptional repressor that plays a role in Wnt signaling and induces cellular transformation.…”

Section: Discussionmentioning

confidence: 99%

Role of MicroRNAs in Progression and Recurrence of Early-Stage Lung Adenocarcinoma

Singh¹,

Bethune²,

Xu³

et al. 2015

Pulm Res Respir Med Open J

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“…Epidemiological studies indicate that a high concentration of blood-circulating IGF-1 (endocrine fraction) is a risk factor in numerous types of cancer, including colon cancer ( 20 ), prostate cancer ( 21 , 22 ), breast cancer ( 22 ) and non-small cell lung cancer ( 23 ). Although the level of circulating IGF-1 is affected by various factors, including growth hormones and IGFBP concentration, gender, age, ethnic group and nutritional status ( 24 ), studies have demonstrated that 38% of the variance in IGF-1 concentration among individuals is caused by genetic effects ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Analysis of cytosine-adenine repeats in P1 promoter region of IGF-1 gene in peripheral blood cells and cervical tissue samples of females with cervical intraepithelial lesions and squamous cervical cancer

Kwaśniewski

Goździcka-Józefiak

Kotarska

et al. 2014

Molecular Medicine Reports

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High oncogenic risk human papillomaviruses (HPVs) are closely associated with cancer of the cervix. However, HPV infection alone may not be sufficient to cause cervical cancer, and other factors or cofactors may have a cumulative effect on the risk of progression from cervical HPV infection to cancer. The present study investigates the cytosine-adenine (CA) repeat polymorphism in the P1 promoter region of the insulin-like growth factor-1 (IGF-1) gene among cervical precancerous and cancer patients and healthy control females. The association between these polymorphisms, tissue and blood serum levels of IGF-1, and cervical cancer risk and progression is evaluated. The material for analysis consisted of blood cells and postoperative tissues from patients diagnosed with low-grade squamous intraepithelial lesions (L-SILs), high-grade squamous intraepithelial lesions (H-SILs) and invasive cervical cancer (ICC). A polymerase chain reaction amplification and the sequencing of DNA were used for the identification of (CA)n repeats in the IGF-1 P1 region and detection of HPV DNA. The blood serum concentration of IGF was determined by enzyme-linked immunosorbent assay. The identification of the IGF-1 protein in the cervical tissues was performed by immunohistochemical analysis. The range of the length of the CA repeats in the study DNA was 11 to 21. However, the most common allele length and genotype in the control and study patients from serum and tissues was 19 CA repeats and a homozygous genotype of CA19/19. Statistically significant differences in the concentration of IGF-1 in the blood serum were observed between H-SILs and controls, only (p=0.047). However, the concentration of IGF-1 in the group of females with CA19/19, CA19<19 and CA19>19 was significantly higher in the group of patients with H-SIL (P=0.041) and ICC (P=0.048) in comparison with the control group. An association was detected between CA repeat length <19 and/or >19, IGF concentration in blood serum and tissues and the development of cervical cancer.

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Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer

Cited by 25 publications

References 16 publications

IGF2R Expression is Associated with the Chemotherapy Response and Prognosis of Patients with Advanced NSCLC

IGF2R Expression is Associated with the Chemotherapy Response and Prognosis of Patients with Advanced NSCLC

Role of MicroRNAs in Progression and Recurrence of Early-Stage Lung Adenocarcinoma

Analysis of cytosine-adenine repeats in P1 promoter region of IGF-1 gene in peripheral blood cells and cervical tissue samples of females with cervical intraepithelial lesions and squamous cervical cancer

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