Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma

Jiang, Hao; Gao, Xiang; Wang, Yaping; Liu, Qing; Zhu, Hai; Zhao, S. J.; Qin, Qiaohong; Meng, Jian; Li, Linlin; Lin, Shaochong; Song, Zhenzhen; Li, Hongyu

doi:10.1097/cad.0000000000001280

Cited by 5 publications

(9 citation statements)

References 24 publications

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“…Moreover, the JAG1–CD46 interaction was detected in only HSIL and not at other disease stages; this interaction has been reported to induce the differentiation of CD4+ T cells into Tregs, representing the emergence of immunoregulatory features. (4) As precancerous lesions progressed into CC, we discovered ligand–receptor interactions, including CXCL17–GPR35 and WNT7B–FZD1, which exerted protumour effects by stimulating cancer cell proliferation and migration 37–39 . In addition, we detected CEACAM5–CD1D interactions between HPV‐related CA cells and myeloid cells and CEACAM5–CD8A interactions between HPV‐related CA cells and CD8+ T cells.…”

Section: Resultsmentioning

confidence: 91%

“…(4) As precancerous lesions progressed into CC, we discovered ligand-receptor interactions, including CXCL17-GPR35 and WNT7B-FZD1, which exerted protumour effects by stimulating cancer cell proliferation and migration. [37][38][39] In addition, we detected CEACAM5-CD1D interactions between HPV-related CA cells and myeloid cells and CEACAM5-CD8A interactions between HPV-related CA cells and CD8+ T cells. Given that CEACAM5 expression is closely related to HPV DNA integration into the host genome, 40 we inferred that the above cellular crosstalk mediated tumour-associated antigen presentation and immune activation of CD8+ T cells.…”

Section: F I G U R E 5 Cell-cell Communication Among Epithelial T And...mentioning

confidence: 79%

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Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix, precancer to cervical cancer: Integrating single‐cell RNA‐sequencing and spatial transcriptome

Guo

Tang

et al. 2023

Clinical & Translational Med

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Background The mechanism underlying cervical carcinogenesis that is mediated by persistent human papillomavirus (HPV) infection remains elusive. Aims Here, for the first time, we deciphered both the temporal transition and spatial distribution of cellular subsets during disease progression from normal cervix tissues to precursor lesions to cervical cancer. Materials & Methods We generated scRNA‐seq profiles and spatial transcriptomics data from nine patient samples, including two HPV‐negative normal, two HPV‐positive normal, two HPV‐positive HSIL and three HPV‐positive cancer samples. Results We not only identified three ‘HPV‐related epithelial clusters’ that are unique to normal, high‐grade squamous intraepithelial lesions (HSIL) and cervical cancer tissues but also discovered node genes that potentially regulate disease progression. Moreover, we observed the gradual transition of multiple immune cells that exhibited positive immune responses, followed by dysregulation and exhaustion, and ultimately established an immune‐suppressive microenvironment during the malignant program. In addition, analysis of cellular interactions further verified that a ‘homeostasis‐balance‐malignancy’ change occurred within the cervical microenvironment during disease progression. Discussion We for the first time presented a spatiotemporal atlas that systematically described the cellular heterogeneity and spatial map along the four developmental steps of HPV‐related cervical oncogenesis, including normal, HPV‐positive normal, HSIL and cancer. We identified three unique HPV‐related clusters, discovered critical node genes that determined the cell fate and uncovered the immune remodeling during disease escalation. Conclusion Together, these findings provided novel possibilities for accurate diagnosis, precise treatment and prognosis evaluation of patients with precancer and cervical cancer.

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Section: Resultsmentioning

confidence: 91%

Section: F I G U R E 5 Cell-cell Communication Among Epithelial T And...mentioning

confidence: 79%

Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix, precancer to cervical cancer: Integrating single‐cell RNA‐sequencing and spatial transcriptome

Guo

Tang

et al. 2023

Clinical & Translational Med

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“…It has been speculated that the expression of CXCL17 by tumor cells in CRC contributes to the metastasis and growth of these cells. A study on endometrial adenocarcinoma tissues demonstrated that CXCL17 levels were remarkably elevated, and there is a significant and positive correlation between the expression of CXCL17 and CXCR8 (Hao et al 2022).…”

Section: Role Of Cxcl17 In Human Malignanciesmentioning

confidence: 99%

The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence

Hashemi

Khorramdelazad

2022

J. Cell Commun. Signal.

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Chemokines are immune system mediators that mediate various activities and play a role in the pathogenesis of several cancers. Among these chemokines, C‐X‐C motif chemokine 17 (CXCL‐17) is a relatively novel molecule produced along the airway epithelium in physiological and pathological conditions, and evidence shows that it plays a homeostatic role in most cases. CXCL17 has a protective role in some cancers and a pathological role in others, such as liver and lung cancer. This chemokine, along with its possible receptor termed G protein‐coupled receptor 35 (GPR35) or CXCR8, are involved in recruiting myeloid cells, regulating angiogenesis, defending against pathogenic microorganisms, and numerous other mechanisms. Considering the few studies that have been performed on the dual role of CXCL17 in human malignancies, this review has investigated the possible pro‐tumor and anti‐tumor roles of this chemokine, as well as future treatment options in cancer therapy.

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“…Furthermore, the expression of CXCL17 and GPR35 were considered a prognostic factor for the overall survival of patients who have endometrial cancer. Although it was not examined the role of this axis in the development of endometrial carcinoma, it was postulated that the CXCL17/GPR35 axis might be related to immune system regulation in the tumor microenvironment (Hao et al, 2022).…”

Section: Cxcl17 Genomic Characterization Tissue Distribution Receptor...mentioning

confidence: 99%

A comprehensive review of chemokine CXC17 (VCC1) in cancer, infection, and inflammation

Shabgah

Jadidi‐Niaragh

Ebrahimzadeh

et al. 2022

Cell Biology International

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A crucial component of the immune system are chemokiness. Chemokine's dysregulation has been linked to a number of pathological diseases. Recently, CXCL17, a chemokine belonging to the CXC subfamily, was identified. With regard to a number of physiological conditions and disorders, CXCL17 either has homeostatic or pathogenic effects. Some research suggests that CXCL17 is an orphan ligand, despite the fact that G protein-coupled receptor (GPR) 35 has been suggested as a possible receptor for CXCL17. Since CXCL17 is primarily secreted by mucosal epithelia, such as those in the digestive and respiratory tracts, under physiological circumstances, this chemokine is referred to as a mucosal chemokine.Macrophages and monocytes are the cells that express GPR35 and hence react to CXCL17. In homeostatic conditions, this chemokine has anti-inflammatory, antibacterial, and chemotactic properties. CXCL17 promotes angiogenesis, metastasis, and cell proliferation in pathologic circumstances like malignancies. However, other studies suggest that CXCL17 may have anti-tumor properties. Additionally, studies have shown that CXCL17 may have a role in conditions such as idiopathic pulmonary fibrosis, multiple sclerosis, asthma, and systemic sclerosis. Additionally,

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Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma

Cited by 5 publications

References 24 publications

Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix, precancer to cervical cancer: Integrating single‐cell RNA‐sequencing and spatial transcriptome

Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix, precancer to cervical cancer: Integrating single‐cell RNA‐sequencing and spatial transcriptome

The cryptic role of CXCL17/CXCR8 axis in the pathogenesis of cancers: a review of the latest evidence

A comprehensive review of chemokine CXC17 (VCC1) in cancer, infection, and inflammation

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