Expression and clinical significance of PRKDC in lung cancer based on bioinformatics analysis

Abstract

Objective: To investigate the expression and prognostic significance of protein kinase DNA activated catalytic subunit (PRKDC) in non-small cell lung cancer (NSCLC). Methods: oncomine, ualcan, human protein Altas, Kaplan Meier plot and c-bioportal databases were searched to analyze the mRNA expression, protein expression, clinicopathological parameters, prognosis, survival and gene mutation of PRKDC in NSCLC and normal lung tissues.Results: the overexpression of PRKDC mRNA and protein in pathological tissues was significantly correlated with the stage of lung adenocarcinoma (luad) and lung squamous cell carcinoma (lusc), smoking habits, gender, race and lymph node metastasis, and significantly correlated with the shortening of overall survival rate (OS) of NSCLC patients. At the same time, PRKDC had a high mutation rate in NSCLC（ LUAD:23% ，LUSC:19% ）The patients with luad had shorter OS and disease-free survival Survival rate (DPS) was significantly correlated.Conclusion: PRKDC may be a biomarker for the prognosis of NSCLC patients.