Expression and clinical value of the soluble major histocompatibility complex class I-related chain A molecule in the serum of patients with renal tumors

Yk, Zhao; Cm, Jia; Gj, Yuan; W, Liu; Qiu, Yue; Qg, Zhu

doi:10.4238/2015.june.29.16

Cited by 15 publications

(14 citation statements)

References 12 publications

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“…High levels of circulating soluble MIC have been associated with poor clinical prognosis and metastasis in multiple cancer types, such as breast, colorectal, ovarian, prostate, lung and other cancers [13,45–47]. Shedding of other family of NKG2D ligands, such as ULBP2 has also been reported to correlate with poor prognosis in selected cancer of solid tumors and hematological malignancies [48–52].…”

Section: Nkg2d Ligands In Human Cancermentioning

confidence: 99%

NKG2D and its ligands in cancer

Dhar

2018

Current Opinion in Immunology

170

128

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NKG2D is an activating immune receptor expressed by NK and effector T cells. Induced expression of NKG2D ligand on tumor cell surface during oncogenic insults renders cancer cells susceptible to immune destruction. In advanced human cancers, tumor cells shed NKG2D ligand to produce an immune soluble form as a means of immune evasion. Soluble NKG2D ligands have been associated with poor clinical prognosis in cancer patients. Harnessing NKG2D pathway is considered a viable avenue in cancer immunotherapy over recent years. In this review, we will discuss the progress and perspectives.

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Section: Nkg2d Ligands In Human Cancermentioning

confidence: 99%

NKG2D and its ligands in cancer

Dhar

2018

Current Opinion in Immunology

170

128

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“…It has been widely reported that low cell surface expression of MICA/B or elevated sera levels of soluble MICA and MICB correlate with metastasis in different types of cancer [67,68,69,70,71,72,73,74]. Elevated sera levels of soluble ULBP2 are an indicator of progression in melanoma patients [75].…”

Section: Metastasis and Evasion Of Nk Cell Surveillancementioning

confidence: 99%

NK Cell-Based Immunotherapy in Cancer Metastasis

Lorenzo‐Herrero

López‐Soto

Sordo‐Bahamonde

et al. 2018

Cancers

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Metastasis represents the leading cause of cancer-related death mainly owing to the limited efficacy of current anticancer therapies on advanced malignancies. Although immunotherapy is rendering promising results in the treatment of cancer, many adverse events and factors hampering therapeutic efficacy, especially in solid tumors and metastases, still need to be solved. Moreover, immunotherapeutic strategies have mainly focused on modulating the activity of T cells, while Natural Killer (NK) cells have only recently been taken into consideration. NK cells represent an attractive target for cancer immunotherapy owing to their innate capacity to eliminate malignant tumors in a non-Major Histocompatibility Complex (MHC) and non-tumor antigen-restricted manner. In this review, we analyze the mechanisms and efficacy of NK cells in the control of metastasis and we detail the immunosubversive strategies developed by metastatic cells to evade NK cell-mediated immunosurveillance. We also share current and cutting-edge clinical approaches aimed at unleashing the full anti-metastatic potential of NK cells, including the adoptive transfer of NK cells, boosting of NK cell activity, redirecting NK cell activity against metastatic cells and the release of evasion mechanisms dampening NK cell immunosurveillance.

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“…On the other hand, the MICA and MICB have been described as generally highly polymorphic genes . Associations of these polymorphisms with different types of human diseases indicate their functional importance . MR1 polymorphisms are associated with the development of tuberculosis in humans, while MICA/B genetic variation is associated with viral as well as bacterial disease .…”

Section: Introductionmentioning

confidence: 99%

“…22 Associations of these polymorphisms with different types of human diseases indicate their functional importance. [23][24][25][26] MR1 polymorphisms are associated with the development of tuberculosis in humans, 27 while MICA/B genetic variation is associated with viral as well as bacterial disease. 28,29 For all these reasons, MHC class I and MHC class I-related molecules are of interest for biomedical research.…”

mentioning

confidence: 99%

The major histocompatibility complex of Old World camelids: Class I and class I‐related genes

Plášil

Wijkmark

Elbers³

et al. 2019

HLA

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The genomic structure of the Major Histocompatibility Complex (MHC) region and variation in selected MHC class I related genes in Old World camels, Camelus bactrianus and Camelus dromedaries were studied. The overall genomic organization of the camel MHC region follows a general pattern observed in other mammalian species and individual MHC loci appear to be well conserved. Selected MHC class I genes B‐67 and BL3‐7 exhibited unexpectedly low variability, even when compared to other camel MHC class I related genes MR1 and MICA. Interspecific SNP and allele sharing are relatively common, and frequencies of heterozygotes are usually low. Such a low variation in a genomic region generally considered as one of the most polymorphic in vertebrate genomes is unusual. Evolutionary relationships between MHC class I related genes and their counterparts from other species seem to be rather complex. Often, they do not follow the general evolutionary history of the species concerned. Close evolutionary relationships of individual MHC class I loci between camels, humans and dogs were observed. Based on the results of this study and on our data on MHC class II genes, the extent and the pattern of polymorphism of the MHC region of Old World camelids differed from most mammalian groups studied so far. Camels thus seem to be an important model for our understanding of the role of genetic diversity in immune functions, especially in the context of unique features of their immunoglobulin and T‐cell receptor genes.

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Expression and clinical value of the soluble major histocompatibility complex class I-related chain A molecule in the serum of patients with renal tumors

Cited by 15 publications

References 12 publications

NKG2D and its ligands in cancer

NKG2D and its ligands in cancer

NK Cell-Based Immunotherapy in Cancer Metastasis

The major histocompatibility complex of Old World camelids: Class I and class I‐related genes

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