Expression and Distribution of Junctional Adhesion Molecule-1 in the Human Cornea

Abstract

JAM-1 is expressed by human corneal epithelial and endothelial cells, but not by keratocytes, although its expression is induced in corneal myofibroblasts.

Evaluating the Association between Keratoconus and Reported Genetic Loci in a Han Chinese Population

“…17 MUPP1 interacts with JAM-1, a membrane adhesion protein expressed in corneal epithelial cells with a role in maintenance of corneal epithelial barrier and regulation of cell shape. 16,18,19 Further studies are needed to confirm and evaluate the functional significance of this association. SNP rs2956540 is located in intron 4 of LOX and was reported to be associated with keratoconus in an American population.…”

Characteristics of Reconstituted Tight Junctions After Corneal Epithelial Wounds and Ultrastructure Alterations of Corneas in Type 2 Diabetic Rats

“…TJs play a central role in the regulation of paracellular permeability and are also crucial for the generation and maintenance of polarity by epithelial and endothelial cells. 9 TJs are present on the apical side of epithelia and are thought to play a significant role in the establishment and maintenance of this important eye defense. 10,11 Based on the existing research, the TJ complex are classified into three groups of proteins: transmembrane proteins (claudin, occluding, and junctional adhesion molecules), peripheral membrane proteins (ZO-1, ZO-2, ZO-3, and MUPP-1), which have PDZ domains and bind to transmembrane proteins, and cytoplasmic proteins (cingulin and 7H6 antigen), which exist around TJs without any direct binding.…”

Multidrug Resistance-Associated Protein (MRP1, 2, 4 and 5) Expression in Human Corneal Cell Culture Models and Animal Corneal Tissue

“…The cornea is a transparent avascular tissue consisting of five main layers: the endothelium, Descemet’s membrane, the stroma, Bowman’s membrane and the epithelium, as the outer layer. The epithelium consists of five to six layers of flat, tightly linked squamous cells forming a hydrophobic barrier limiting the passive diffusion of hydrophilic small molecules and macromolecules due to the presence of tight junctions . The stroma accounts for approximately 90% of the thickness of the cornea.…”

“…The epithelium consists of five to six layers of flat, tightly linked squamous cells forming a hydrophobic barrier limiting the passive diffusion of hydrophilic small molecules and macromolecules due to the presence of tight junctions. 3 The stroma accounts for approximately 90% of the thickness of the cornea. It forms a hydrophilic barrier consisting of an organized collagen structure, glycosaminoglycans and various proteoglycans, as a matrix with embedded keratocytes.…”