Expression and distribution pattern of podoplanin in oral submucous fibrosis with varying degrees of dysplasia – an immunohistochemical study

Karunagaran, Monika; Murali, Preethi; Palaniappan, Varun; Sivapathasundharam, B

doi:10.1080/01478885.2019.1594543

Cited by 14 publications

(10 citation statements)

References 10 publications

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“…α‐SMA, 23 podoplanin, 41 cyclooxygenase‐2 (COX2), 42 α‐enolase, 43 p53, 24 p63, 44‐46 ΔNp63, 44 p16, 24 Ki67, 23,27 cytokeratin (CK‐5/6), 44 VEGF, 47 CD105, 23,45,47 vimentin, 48 PCNA, 49 caspase‐3, 50 SOX2, Bmi1, 27 and cytoplasmic expression of E‐cadherin and β‐catenin 49 were upregulated in OSF with dysplasia compared with OSF without dysplasia and normal subjects. Loss of membranous E‐cadherin and β‐catenin was evident in OSF with moderate and severe dysplasia 45–47 …”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical biomarkers in oral submucous fibrosis: A scoping review

Kavitha

Ranganathan

Sivasamy

et al. 2022

J Oral Pathology Medicine

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Oral submucous fibrosis (OSF) is a chronic progressive, potentially malignant disorder involving the oral mucosa and occasionally the pharynx and upper third of the esophagus. It is characterized by juxta-epithelial hyalinization, fibrosis, epithelial atrophy, and stiffness of the oral mucosa causing limitation in mouth opening and difficulty in eating. 1,2 OSF is caused by chewing areca nut, which is the fourth most addictive substance (following alcohol, tobacco, and caffeine), with 600 million people, globally, consuming it. 3,4 It has a malignant transformation rate of 7%-13%. 5 Biomarkers reflecting the molecular changes in OSF have been studied, with the intent of understanding pathogenesis and identifying biomarkers of clinical relevance. Several molecular biomarkers of

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical biomarkers in oral submucous fibrosis: A scoping review

Kavitha

Ranganathan

Sivasamy

et al. 2022

J Oral Pathology Medicine

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“…Our team has extensive knowledge and research experience in various aspects that has translated into high quality publications [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35]. With this background, the present study aims to assess the incidence of Traumatic Ulcers among the patients visiting a Private Dental Hospital in Chennai.…”

Section: Introductionmentioning

confidence: 99%

Incidence of Traumatic Ulcer among the Patients Visiting Private Dental Hospital- Retrospective Study

Selvi

Ramani

2021

JPRI

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Introduction: Oral mucosal ulcers are one of the most common types of ulcer of which Traumatic ulcers are common and acute in nature, caused by some form of trauma to the mucous membrane in the oral cavity. It is most commonly seen in the Buccal Mucosa, Lips, and occasionally in the Palate and Lateral border of tongue. It is caused by physical, chemical or thermal trauma resulting in damage and ulcer formation. Materials and Methods: The data for the present study n = 345 patients was collected by analysing case sheets of patients who visited Saveetha Dental College from June 2019- February 2021. The collected data was subjected to statistical analysis using the SPSS software by IBM of version 23. Results: From the results of the study, Traumatic Ulcer has Male predilection with incidence rate of 62.2% compared to females with incidence of 37.7%. Most of them were in the age group of 21-30 years age group (34.5%) and least in the 71-85 years age group (2.9%). Traumatic ulcer was most common in the Alveolar mucosa (32.2% ) Conclusion: From the present study it can be concluded that Traumatic ulcer is more common in Males. However, Gender, Age, Oral Hygiene, Usage of Tobacco products were not significantly influencing the rate of incidence of Traumatic Ulcer.

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“…Our team has extensive knowledge and research experience that has translated into high quality publications in the same field [20][21][22][23][24][25][26][27][28][29][30][31]. Thus, the present study aims to assess the demographic details of patients clinically diagnosed with Leukoplakia.…”

Section: Introductionmentioning

confidence: 99%

Demographic Profiling of Patients with Leukoplakia Visiting a Dental Hospital in Chennai, India - An Institutional Study

Rajeswaran

Ramani

2021

JPRI

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Introduction: Oral potentially malignant disorders (OPMDs) are a group of conditions that predispose to the development of oral cancers. A few of the commonly recurring OPMDs include leukoplakia, oral submucous fibrosis, Smokers’ palate, and oral lichen planus. Leukoplakia is more common in specific populations, attributed to their habits and environmental circumstances. Hence, early diagnosis with biopsies on suspecting these lesions during regular oral health check-up ensures timely referral and addressal of the disorder. The present study aims to demographically profile patients with Leukoplakia visiting a private dental hospital in Chennai. Aim: To demographically profile patients diagnosed with Leukoplakia, visiting a dental hospital in Chennai, a major city in the state of Tamil Nadu, India. Materials and Methods: From the patients visiting the private dental hospital, those clinically diagnosed with Leukoplakia were considered in the inclusion criteria. Exclusion criteria involved those with poor maintenance of records and lack of follow-up of uncooperative patients. The sample size was n=100. The gender, age and locality of residence were considered and tabulated, followed by their statistical analysis using SPSS software version 22.0. Results: From the results of the current study, it was observed that there was a greater male predilection to the occurrence of Leukoplakia (99%) compared to females (1%). A greater number of cases were seen in the age group of 41-50 years (34%), while the least number of cases were seen in patients of 21-30 years (7%). Among the cases reported, most patients were from Thiruvallur (40%), Chennai district (30%) followed by Kancheepuram district (17%) in Tamilnadu . Conclusion: From the study, it can be concluded that Leukoplakia is more prevalent among the middle aged male population and was found to be predominantly occurring in the regions of Thiruvallur and Chennai districts in Chennai, Tamil Nadu.

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Expression and distribution pattern of podoplanin in oral submucous fibrosis with varying degrees of dysplasia – an immunohistochemical study

Cited by 14 publications

References 10 publications

Immunohistochemical biomarkers in oral submucous fibrosis: A scoping review

Immunohistochemical biomarkers in oral submucous fibrosis: A scoping review

Incidence of Traumatic Ulcer among the Patients Visiting Private Dental Hospital- Retrospective Study

Demographic Profiling of Patients with Leukoplakia Visiting a Dental Hospital in Chennai, India - An Institutional Study

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