2021
DOI: 10.21203/rs.3.rs-144862/v1
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Expression and Function of C1orf132 Long-Noncoding RNA, in Breast Cancer Cell Lines and Tissues

Abstract: MIR29B2CHG/C1orf132 is the host gene for generating miR-29b2 and miR-29c. Here, we employed bioinformatics and experimental approaches to decipher expression of C1orf132 in breast cancer cells and tissues. Our data demonstrated a significant downregulation of C1orf132 in triple-negative breast cancer. We also predicted a putative promoter for the longer transcripts of C1orf132. The functionality of the distal promoter was confirmed by transfecting MCF7 cells with a C1orf132 promoter-GFP construct. Knocking-out… Show more

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Cited by 2 publications
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“…29,30 MIR29B2CHG (also known as C1orf132) is the host gene of miR-29b2 and miR-29c, and has been shown to be down-regulated as an alternative longer transcript in triple-negative breast cancer. 31 We speculate that the gene fusions might also disturb the tumor-suppressing function of these non-coding RNAs. Of potential importance, exon 1 of LINC-PINT contains a highly conserved sequence element essential for its ability to inhibit tumor invasiveness, 32 which would be lost in the COL1A2::LINC-PINT fusion.…”
Section: Discussionmentioning
confidence: 94%
“…29,30 MIR29B2CHG (also known as C1orf132) is the host gene of miR-29b2 and miR-29c, and has been shown to be down-regulated as an alternative longer transcript in triple-negative breast cancer. 31 We speculate that the gene fusions might also disturb the tumor-suppressing function of these non-coding RNAs. Of potential importance, exon 1 of LINC-PINT contains a highly conserved sequence element essential for its ability to inhibit tumor invasiveness, 32 which would be lost in the COL1A2::LINC-PINT fusion.…”
Section: Discussionmentioning
confidence: 94%

miRNAs as Interconnectors between Obesity and Cancer

González-Sánchez,
Granados-López,
López-Hernández
et al. 2024
ncRNA