Expression and function of Slc34 sodium–phosphate co-transporters in skeleton and teeth

Beck, Laurent

doi:10.1007/s00424-018-2240-y

Cited by 13 publications

(10 citation statements)

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“…PIT2 appears to be involved during the mineralization of dentin, as suggested by the dentin dysplasia described in the global Pit2 knockout [ 281 ]. Slc34a1/Npt2a and Slc34a2/Npt2b are expressed in the MRPC-1 rat odontoblast-like mineralizing pulpal cell line [ 283 , 284 ]. Slc34a2/Npt2b is negligibly expressed in ameloblasts during the secretory stage, but it is significantly upregulated in the maturation stage [ 281 , 284 , 285 ].…”

Section: Importance Of Dietary Phosphorus For Teeth (Or Dental Heamentioning

confidence: 99%

“…Slc34a1/Npt2a and Slc34a2/Npt2b are expressed in the MRPC-1 rat odontoblast-like mineralizing pulpal cell line [ 283 , 284 ]. Slc34a2/Npt2b is negligibly expressed in ameloblasts during the secretory stage, but it is significantly upregulated in the maturation stage [ 281 , 284 , 285 ]. However, the role of Npt2b in tooth development and mineralization is unknown [ 284 ].…”

Section: Importance Of Dietary Phosphorus For Teeth (Or Dental Heamentioning

confidence: 99%

“…Slc34a2/Npt2b is negligibly expressed in ameloblasts during the secretory stage, but it is significantly upregulated in the maturation stage [ 281 , 284 , 285 ]. However, the role of Npt2b in tooth development and mineralization is unknown [ 284 ].…”

Section: Importance Of Dietary Phosphorus For Teeth (Or Dental Heamentioning

confidence: 99%

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Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging

Serna

Bergwitz

2020

Nutrients

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Inorganic phosphate (Pi) plays a critical function in many tissues of the body: for example, as part of the hydroxyapatite in the skeleton and as a substrate for ATP synthesis. Pi is the main source of dietary phosphorus. Reduced bioavailability of Pi or excessive losses in the urine causes rickets and osteomalacia. While critical for health in normal amounts, dietary phosphorus is plentiful in the Western diet and is often added to foods as a preservative. This abundance of phosphorus may reduce longevity due to metabolic changes and tissue calcifications. In this review, we examine how dietary phosphorus is absorbed in the gut, current knowledge about Pi sensing, and endocrine regulation of Pi levels. Moreover, we also examine the roles of Pi in different tissues, the consequences of low and high dietary phosphorus in these tissues, and the implications for healthy aging.

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Section: Importance Of Dietary Phosphorus For Teeth (Or Dental Heamentioning

confidence: 99%

Section: Importance Of Dietary Phosphorus For Teeth (Or Dental Heamentioning

confidence: 99%

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Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging

Serna

Bergwitz

2020

Nutrients

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“…The SLC system is increasingly used, i.e., SLC34A1, SLC34A2, and SLC34A3 for the human type II transporters NaPi-IIa, NaPi-IIb, and NaPi-IIc, respectively. The structurally similar isoforms are grouped into the same sub-family (SLC34A) with individual indices (1,2,3). This nomenclature is easily applicable to most vertebrates; it only becomes less clear in the case of fish that have undergone genome duplications followed by lineage specific gene losses.…”

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confidence: 99%

“…It is our hope that these articles will provide a useful overview for experts and non-experts alike and stimulate continued research in the P i field. The reviews have been grouped according to five themes: Molecular and Mechanistic Aspects, including interacting proteins [12,13,23,43], Physiological Regulation [26,27,48], Human Mutations/Clinical Aspects and Diseases [4,30], Non-renal Roles for SLC34 Proteins [3,34], and Comparative Aspects [39,52].…”

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Phosphate transport: from microperfusion to molecular cloning

Murer

Biber

Forster

et al. 2018

Pflugers Arch - Eur J Physiol

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Inorganic phosphate (P i ) is a constituent of important biological molecules (e.g., nucleic acids and phospholipids) and is essential for cellular energetics and signaling, and protein synthesis as well as skeletal development in all mammalian organisms. Inadequate P i supply causes bone malformations such as rickets and spinal deformations, whereas an excess in P i is linked to vascular calcification or ectopic CaP i deposits. In general, whole-body P i homeostasis is maintained by transepithelial transport mechanisms in the small intestine and kidney where P i is absorbed from the diet and reabsorbed from the glomerular filtrate, respectively. The renal proximal tubule is the main locus of P i regulation so that under Bsteady-state^physiological conditions, renal P i -excretion corresponds approximately to dietary P i intake.Membrane transport proteins belonging to the SLC34 solute carrier family 1 lie at the heart of maintaining P i homeostasis. In the small intestine, NaPi-IIb (SLC34A2) mediates luminal P i uptake together with a paracellular component, whereas the renal isoforms NaPi-IIa (SLC34A1) and NaPi-IIc (SLC34A3) are responsible for P i reabsorption in the proximal tubule. This Special Issue focusing on phosphate transport mediated by SLC34 proteins was conceived to coincide with an important milestone in renal physiology: the expression cloning of the first member of the SLC34 family (NaPi-IIa) just over a quarter of a century ago [33]. This, together with the subsequent identification of the other two SLC34 isoforms [24,42], has paved the way for a deeper understanding of the molecular basis of P i homeostasis, many aspects of which are the subject of dedicated reviews in this issue. Whereas the pivotal role of SLC34 cotransporters in maintaining P i homeostasis is undisputed, other carriers such as PIT-1 and PIT-2 (SLC20 family) may also contribute to epithelial transport of P i in the intestine and the kidney. However, their respective contributions to 1 Historically, the nomenclature of the cloned, mammalian P i transporters followed a strictly chronological convention, beginning with the type 1 (NaPi-I) [10,53] (since shown to be related to an anion conductance and not directly mediate Na-dependent P i transport [8]); the type II (NaPi-II [33] or npt2) and the type III (NaPi-III [28,29], or Pit-1,2). The widely used solute carrier (SLC) nomenclature [22] assigns the type I transporters to the SLC17 gene family; type II Na-P i transporters to SLC34 and type III transporters to SLC20, respectively. The SLC system is increasingly used, i.e., SLC34A1, SLC34A2, and SLC34A3 for the human type II transporters NaPi-IIa, NaPi-IIb, and NaPi-IIc, respectively. The structurally similar isoforms are grouped into the same sub-family (SLC34A) with individual indices (1, 2, 3). This nomenclature is easily applicable to most vertebrates; it only becomes less clear in the case of fish that have undergone genome duplications followed by lineage specific gene losses.

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Calcium and Phosphate Ion Uptake, Distribution, and Homeostasis in Cells of Vertebrate Mineralized Tissues

Shapiro,

Landis

2023

Mechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues

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Expression and function of Slc34 sodium–phosphate co-transporters in skeleton and teeth

Cited by 13 publications

References 93 publications

Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging

Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging

Phosphate transport: from microperfusion to molecular cloning

Calcium and Phosphate Ion Uptake, Distribution, and Homeostasis in Cells of Vertebrate Mineralized Tissues

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