Expression and localization of leptin receptor in the normal rat pituitary gland

Sone, Masayuki; Nagata, Hidetaka; Takekoshi, Susumu; Ry, Osamura

doi:10.1007/s004410100407

Cited by 71 publications

(74 citation statements)

References 42 publications

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“…LEPR immunoreactivity was shown in 69% of somatotropes, which fits well with what we have reported in rats and mice [93,98,117]. Sone et al [99,100] detected LEPR in 97% of rat pituitary somatotropes.…”

Section: The Case For Leptin As a Paracrine Regu-lator In The Anteriosupporting

confidence: 90%

“…Evidence is growing that leptin is produced by the anterior pituitary and the hypothalamus [31,93,[96][97][98][99][100]. A pituitary source would point to a paracrine role for this cytokine.…”

Section: The Case For Leptin As a Paracrine Regu-lator In The Anteriomentioning

confidence: 99%

“…The hypothesis that pituitary leptin might be a paracrine factor is further supported by the fact that subsets of all pituitary cells have leptin receptors (LEPR) [30,96,97,[99][100][101]. LEPR are related to the class 1 cytokine receptor superfamily [104,105].…”

Section: The Case For Leptin As a Paracrine Regu-lator In The Anteriomentioning

confidence: 99%

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Pituitary Leptin-A Paracrine Regulator of Gonadotropes: A Review

2011

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Leptin, a potent anorexigenic hormone secreted primarily by adipocytes, is known to be expressed in the anterior pituitary. Studies in our laboratory found leptin proteins and mRNA predominantly in somatotropes in normal male and cycling female rats. In contrast, leptin expression predominated in gonadotropes during pregnancy and lactation. Leptin expression varied with the cycle and was enhanced, in vitro by gonadotropin releasing hormone and Neuropeptide Y. In contrast, ghrelin inhibited pituitary leptin expression. Pituitary leptin in somatotropes or gonadotropes was reduced by nutritional deprivation for 24 h. However, growth hormone (GH), luteinizing hormone (LH) and pituitary leptin recovered if fasted animals were given glucose water. The glucose-mediated recovery suggests that the system is sensitive to changes in serum glucose. Somatotropes and gonadotropes also recovered if pituitary cells from fasted rats were stimulated in vitro with 1-100 pg/ml leptin. This in vitro leptin-mediated recovery suggests that leptin is important in the maintenance of somaotropes and gonadotropes. Collectively, the data suggest that pituitary leptin might serve as a "glucostat", sensing levels of serum glucose and reporting this nutritional state to somaotropes and gonadotropes in a paracrine manner. A decrease in pituitary leptin might signal nutritional deprivation to somatotropes and gonadotropes, lowering LH and GH production and allowing for conservation of resources. Lower GH would help conserve fat stores and lower LH would promote survival over reproduction.

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Section: The Case For Leptin As a Paracrine Regu-lator In The Anteriosupporting

confidence: 90%

Section: The Case For Leptin As a Paracrine Regu-lator In The Anteriomentioning

confidence: 99%

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Pituitary Leptin-A Paracrine Regulator of Gonadotropes: A Review

2011

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“…The detection of leptin receptor in the human [3][4][5] and rat [6,7] pituitary gland has raised the possibility of that circulating leptin might also act directly to modulate TSH release. Moreover, recently, leptin was defined in anterior pituitary gland of human [3], rat and mouse [6,7].…”

mentioning

confidence: 99%

“…Moreover, recently, leptin was defined in anterior pituitary gland of human [3], rat and mouse [6,7].…”

mentioning

confidence: 99%

TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

et al. 2005

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Abstract. Leptin is considered to play a role in maintenance of energy balance and body weight by neuroendocrine mechanisms. The physiological mechanisms for thyroid hormone-induced alteration in serum leptin are not well known. In the present study, the relationship between thyroid hormones and leptin levels was investigated in patients with overt hypothyroidism and hyperthyroidism before and after successful treatment. Leptin levels were determined by radioimmunoassay and body mass index (BMI) was calculated for each subject. Serum leptin levels of 26 hypothyroid and 22 hyperthyroid patients were compared with those of 20 healthy volunteers who comprised the controls. Serum leptin levels of hypothyroid patients (28.4 ± 4.1 ng/ml) were found to be significantly higher than the controls (19.1 ± 3.2 ng/ml) (p<0.01), whereas hyperthyroid patients had lower levels (10.7 ± 1.2 ng/ml) (p<0.01). In hypothyroid patients, serum leptin levels were decreased significantly to 20.6 ± 2.1 ng/ml with thyroxin treatment (p<0.05). However, in hyperthyroid group, serum leptin levels were increased to 12.4 ± 2.2 ng/ml by treatment (p>0.05). BMI was not changed with the treatment in either group. The serum leptin levels were correlated with BMI and thyrotropin (TSH) in both hypothyroid and hyperthyroid patients. Serum leptin levels are affected in thyroid disorders and the correlation of leptin with TSH is independent of thyroid hormones.

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Leptin and Pubertal Development in Higher Primates

Mann

Plant

2003

Leptin and Reproduction

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Expression and localization of leptin receptor in the normal rat pituitary gland

Cited by 71 publications

References 42 publications

Pituitary Leptin-A Paracrine Regulator of Gonadotropes: A Review

Pituitary Leptin-A Paracrine Regulator of Gonadotropes: A Review

TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

Leptin and Pubertal Development in Higher Primates

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