Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation

Xu, Zhengkuan; Zhou, Xiaopeng; Chen, Gang

doi:10.12659/msm.911910

Cited by 20 publications

(18 citation statements)

References 18 publications

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“…The expression levels of IL-12, as well as some other cytokines such as IL-4 and TNF-α, were decreased after applying this method, which could indicate its effectiveness in treating IVDD [16]. The mRNA expression of IL-2 was also remarkably higher in another model of disc herniation in rats [17]. In an animal model of disc herniation in rats, dorsal root ganglions were exposed to NP, and epidural lavage indicated higher expression of IFN-γ, as well as other cytokines such as IL-4, IL-6, and TNF-α [18].…”

Section: Discussionmentioning

confidence: 84%

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

et al. 2020

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Background: Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting with low back pain or radicular pain. The inflammatory changes would occur in discs in the process of IVDD. Therefore, the inflammatory and anti-inflammatory cytokines, as well as their respective genes, have been proposed to play roles in pathophysiology of disease. This study has been conducted to elucidate the role of IL-2, IL-12, and IFN-γ single nucleotide polymorphisms (SNP) in this disease. Method: Seventy-six patients who were diagnosed with IVDD and 140 healthy controls who complied with eligibility criteria were included. A total volume of 5 cc peripheral blood was obtained from each participant to investigate the IL-2 + 166G/T, IL-2-330G/T, IL-12 − 1188A/C, and IFN-γ +847A/T SNPs through PCR-SSP method. Results: The 'TG' and 'TT' genotypes of IL-2 − 330G/T polymorphism were significantly more common among patients and healthy controls respectively. The 'GT' and 'TT' haplotypes of IL-2 (comprised of-330G/T, and + 166G/T SNPs) were also more common among patients and controls respectively. Conclusion: This study indicated the significant role of IL-2 genotypes and haplotypes in IVDD. These SNPs were differently distributed in patients and controls. Therefore, alteration in the structure of IL-2 gene could play an important role in pathophysiology of IVDD.

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Section: Discussionmentioning

confidence: 84%

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

et al. 2020

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“…The expression levels of IL-12, as well as some other cytokines such as IL-4 and TNF-α, were decreased after applying this method, which could indicate its effectiveness in treating IVDD [15]. The mRNA expression of IL-2 was also remarkably higher in another model of disc herniation in rats [16]. In an animal model of disc herniation in rats, dorsal root ganglions were exposed to NP, and epidural lavage indicated higher expression of IFN-γ, as well as other cytokines such as IL-4, IL-6, and TNF-α [17].…”

Section: Discussionmentioning

confidence: 84%

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

Hanaei

Abdollahzade

Sadr

et al. 2020

Preprint

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Abstract Background: Intervertebral disc degeneration (IVDD) is an age-related degenerative disease, presenting low back pain or radicular pain in a variety of severity. As the inflammatory changes in discs, the inflammatory and anti-inflammatory cytokines, as well as their respective genes, have been proposed to play role in pathophysiology of disease. This study has been conducted to elucidate the role of IL-2, IL-12, and IFN-γ single nucleotide polymorphisms (SNP) in this disease.Method: 76 patients diagnosed with IVDD and 140 healthy subjects who have complied with eligibility criteria have been included. A total volume of 5cc peripheral blood of each participant has been used for investigating the IL-2 +166G/T, IL-2 -330G/T, IL-12 -1188A/C, and IFN-γ +847A/T single nucleotide polymorphisms (SNP) through PCR-SSP method.Results: The ‘TG’ and ‘TT’ genotypes of IL-2 -330G/T polymorphism have been significantly more common among patients and healthy controls respectively and therefore were associated with disease. The ‘GT’ and ‘TT’ haplotypes of IL-2, comprised of -330G/T, and +166G/T, have been also more common among patients and controls respectively.Conclusion: This study has indicated significant role of IL-2 genotypes and haplotypes in IVDD, as they have been differently distributed in cases and controls. Therefore, alteration in IL-2 gene structure could play an important role in pathophysiology of IVDD through alteration of its function.

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“…Decompression techniques (endoscopic, micro-or open-discectomy, different types of chemonucleolysis, intraspinous process devices) address the mechanical pressure exerted by the herniated disc on the nerve root exiting the intervertebral foramen. Trials with platelet-rich plasma or mesenchymal stem cells injected into the disc seek to restore the balance between the catabolic, pro-inflammatory (interleukin-1 [25] and anabolic mediators (insulin-like growth factor, fibroblast growth factor, bone morphogenic protein [26,27,28]). The aim is the restoration of healthy disc properties and preventing the chemical irritation of the neural structures.…”

Section: Discussionmentioning

confidence: 99%

Short-term outcome after microdiscectomy for lumbar disc herniation – a single centre study

Kulesza¹,

Szmygin²,

Krukow³

et al. 2021

J Pre Clin Clin Res.

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Introduction. Lumbar disc herniation (LDH) is a common cause of back pain and leg pain. For more than 60 years, standard discectomy by fenestration has been used to treat LDH. In his study, three commonly used scales were used to assess the outcome after microdiscectomy, such as the Low Back Pain Rating Scale (LBPRS), Oswestry Disability Index (ODI) and the Visual Analogue Scale (VAS). To the best of the authors' knowledge, this is the first study analyzing treatment results at 3 months after microdiscectomy. Materials and method. During almost 5 years, a total of 327 patients underwent microdiscectomy operations for single level disc disease. Of these, 286 patients were available for 3-mounth follow-up. All patients were operated on at the Neurosurgery Department in the Specialist Hospital in Sandomierz, Poland. Before surgery and 3 months after burgery, all patients were asked to complete LBPRS, ODI and VAS scales. The statistical analysis used was p2, the effect size indicator for ANOVA. Results. Significant improvement was observed in all scales used 3 months after surgery. Conclusions. There are new, minimally invasive percutaneous techniques available, such as percutaneous laser disc decompression and intradiscal injection of radiopaque gelified ethanol. There are also trials with platelet-rich plasma or mesenchymal stem cells injected into the disc, aimed at the restoration of healthy disc properties. The hypothesis that metabolic products of bacteria propionibacterium acnes can contribute to disc degeneration inspired attempts at antibiotic therapy This study was conducted on a large group of patients and confirmed that discectomy is the recommended method of surgery which produces good treatment results in 3-mounths follow-up.

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Expression and Mechanism of Interleukin 1 (IL-1), Interleukin 2 (IL-2), Interleukin 8 (IL-8), BMP, Fibroblast Growth Factor 1 (FGF1), and Insulin-Like Growth Factor (IGF-1) in Lumbar Disc Herniation

Cited by 20 publications

References 18 publications

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

Association of interleukin 2, interleukin 12, and interferon-γ with intervertebral disc degeneration in Iranian population

Short-term outcome after microdiscectomy for lumbar disc herniation – a single centre study

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