Expression and potential role of the extracellular matrix in hepatic ontogenesis: A review

Amenta, Peter S.; Harrison, Douglas A.

doi:10.1002/(sici)1097-0029(19971115)39:4<372::aid-jemt7>3.0.co;2-j

Cited by 66 publications

(36 citation statements)

References 145 publications

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“…Laminin, which can be directly cleaved by plasmin (29), is highly expressed around embryonic sinusoids but is downregulated in perisinusoidal spaces close to birth (36). Interestingly, laminin is transiently upregulated again around sinusoidal vessels during liver regeneration (37).…”

Section: Discussionmentioning

confidence: 99%

CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity

Crosswhite¹,

Podsiadlowska²,

Curtis³

et al. 2016

Journal of Clinical Investigation

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Section: Discussionmentioning

confidence: 99%

CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity

Crosswhite¹,

Podsiadlowska²,

Curtis³

et al. 2016

Journal of Clinical Investigation

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“…However, the role of myofibroblasts and fibroblasts in the regulation of hematopoiesis has not been studied sufficiently. Some data suggest their involvement in organizing the hematopoietic microenvironment by producing extracellular matrix components, including fibronectin and collagen [37]. Adhesion to fibronectin appears to stimulate proliferation of both hematopoietic stem/progenitor and erythroid cells [38,39], which is confirmed by correlation between the content of this protein in the periportal region and the activity of hematopoiesis in human fetal liver [40].…”

Section: Fibroblasts and Myofibroblastsmentioning

confidence: 98%

Hematopoietic Microenvironment in the Fetal Liver: Roles of Different Cell Populations

Payushina

2012

ISRN Cell Biology

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Hematopoiesis is the main function of the liver during a considerable period of mammalian prenatal development. Hematopoietic cells of the fetal liver exist in a specific microenvironment that controls their proliferation and differentiation. This microenvironment is created by different cell populations, including epitheliocytes, macrophages, various stromal elements (hepatic stellate cells, fibroblasts, myofibroblasts, vascular smooth muscle and endothelial cells, mesenchymal stromal cells), and also cells undergoing epithelial-to-mesenchymal transition. This paper considers the involvement of these cell types in the regulation of fetal liver hematopoiesis.

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“…During liver development, type IV collagen, and laminin are expressed in and accumulate in the basement membrane of the mesothelium, portal vein, and BECs (Baloch et al, 1992). Fibronectin and type I collagen are expressed in connective tissues surrounding the bile ducts and veins (Amenta and Harrison, 1997). The spatially and temporally distinct patterns of expression of ECM components in the developing liver suggest that they might play important roles in liver development (Amenta and Harrison, 1997).…”

Section: Ecm Components Regulate Gene Expression Of the Hepatic Epithmentioning

confidence: 99%

“…Fibronectin and type I collagen are expressed in connective tissues surrounding the bile ducts and veins (Amenta and Harrison, 1997). The spatially and temporally distinct patterns of expression of ECM components in the developing liver suggest that they might play important roles in liver development (Amenta and Harrison, 1997). Therefore, we examined the effects of ECM components on the expression of marker genes in the developing chick hepatic epithelia.…”

Section: Ecm Components Regulate Gene Expression Of the Hepatic Epithmentioning

confidence: 99%

FGF signaling segregates biliary cell‐lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro

Yanai

Tatsumi

Hasunuma

et al. 2008

Developmental Dynamics

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Intrahepatic bile ducts (IHBDs) are indispensable for transporting bile secreted from hepatocytes to the hepatic duct. The biliary epithelial cells (BECs) of the IHBD arise from bipotent hepatoblasts around the portal vein, suggesting the portal mesenchyme is essential for their development. However, except for Notch or Activin/ TGF-␤ signaling molecules, it is not known which molecules regulate IHBD development. Here, we found that FGF receptors and BMP4 are specifically expressed in the developing IHBD and the hepatic mesenchyme, respectively. Using a mesenchyme-free culture of liver bud, we showed that bFGF and FGF7 induce the hepatoblasts to differentiate into BECs, and that BMP4 enhances bFGF-induced BEC differentiation. The extracellular matrix (ECM) components in the hepatic mesenchyme induced BEC differentiation. Forced expression of a constitutively active form of the FGF receptor partially induced BEC differentiation markers in vivo. These data strongly suggest that bFGF and FGF7 promote BEC differentiation cooperatively with BMP4 and ECMs in vivo.

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Expression and potential role of the extracellular matrix in hepatic ontogenesis: A review

Cited by 66 publications

References 145 publications

CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity

CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity

Hematopoietic Microenvironment in the Fetal Liver: Roles of Different Cell Populations

FGF signaling segregates biliary cell‐lineage from chick hepatoblasts cooperatively with BMP4 and ECM components in vitro

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