2014
DOI: 10.7314/apjcp.2014.15.7.2971
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Expression and Prognostic Significance of lncRNA MALAT1 in Pancreatic Cancer Tissues

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Cited by 135 publications
(101 citation statements)
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“…Moreover, functional analyses have revealed that lncRNAs play essential roles in a range of developmental processes , SuNing Huang 1 , Gang Chen 2 * and diseases, including tumorigenesis and metastasis (Gupta et al, 2010;Cao, 2014;Liu et al, 2014). Aberrantly expressed lncRNAs are a hallmark of carcinomas, suggesting their potential application as predictive and prognostic biomarkers (Li et al, 2014;Liu et al, 2014). Nuclear enriched abundant transcript 1(NEAT1) is a nuclear-restricted lncRNA, which owns two isoforms: 3.7 kb NEAT1_1 and 23 kb NEAT1_2 (Naganuma and Hirose, 2013).…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, functional analyses have revealed that lncRNAs play essential roles in a range of developmental processes , SuNing Huang 1 , Gang Chen 2 * and diseases, including tumorigenesis and metastasis (Gupta et al, 2010;Cao, 2014;Liu et al, 2014). Aberrantly expressed lncRNAs are a hallmark of carcinomas, suggesting their potential application as predictive and prognostic biomarkers (Li et al, 2014;Liu et al, 2014). Nuclear enriched abundant transcript 1(NEAT1) is a nuclear-restricted lncRNA, which owns two isoforms: 3.7 kb NEAT1_1 and 23 kb NEAT1_2 (Naganuma and Hirose, 2013).…”
Section: Introductionmentioning
confidence: 99%
“…A high expression of MALAT1 was detected in PDAC tumors of larger size, advanced tumor stage and deeper invasion. In addition, the overexpression of MALAT1 was associated with poor prognosis of PDAC patients (50). The HOTTIP lncRNA, located at the 5'-end of the HOXA cluster, was significantly expressed in anatomically distal human fibroblasts (51).…”
Section: Discussionmentioning
confidence: 97%
“…MALAT-1 silencing or gene therapy may be effective therapeutic approaches for human tumors (10,38,56). At present, epigenetic mechanisms are important in the regulation of gene expression.…”
Section: Malat-1 and Epigenetic Regulationmentioning
confidence: 99%
“…Importantly, MALAT-1 may be used as a potential therapeutic target (71). Another study indicated that the overexpression of MALAT-1, the tumor location and nerve invasion were independent predictors of disease-specific survival of PDAC (56).…”
Section: Potential Clinical Applications Of Malat-1mentioning
confidence: 99%