Expression and prognostic significance of gastric‐specific annexin A10 in diffuse‐ and intestinal‐type gastric carcinoma

Lu, Su-Hsi; Chen, Yuling; Shun, Chia‐Tung; Shu, Peng; Lai, Po-Lin; Hsu, Hey‐Chi

doi:10.1111/j.1440-1746.2010.06480.x

Cited by 19 publications

(28 citation statements)

References 45 publications

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“…Aberrant ANXA10 expression has been reported to be closely associated with adenocarcinomas of the gastric and pancreatobiliary system [17, 24] as well as colorectal carcinoma (CRC) [16, 25–26]. The ANXA10 expression was highly related to gastric phenotype in the serrated pathway to colorectal carcinoma [16] and associated with poor prognosis in CRCs [25].…”

Section: Discussionmentioning

confidence: 99%

“…Cell surface ANXA2 expression was shown to be strongly upregulated during the progression from low-grade PanIN lesions to pancreatic adenocarcinoma [15]. Increased expression of ANXA10 was closely related to a gastric phenotype in serrated pathway to colorectal carcinoma [16] while the downregulation of ANXA10 was correlated with tumor progression in intestinal-type gastric carcinoma [17]. Compared to the other 12 members in human ANXA family, ANXA10 has distinct features including an unusual single codon deletion and loss of two main type II calcium-binding sites [9, 18], which could result in different functional consequences.…”

Section: Introductionmentioning

confidence: 99%

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Annexin A10 is a candidate marker associated with the progression of pancreatic precursor lesions to adenocarcinoma

Zhu

Pei

et al. 2017

PLoS ONE

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Annexins are a multigene family of calcium and phospholipid-binding proteins that play important roles in calcium signaling, cell motility, differentiation and proliferation. Our previous mass spectrometry-based proteomics study revealed that annexin A10 (ANXA10) was uniquely overexpressed in pancreatic CD24+ adenocarcinoma cells that were dissected from clinical PDAC tissues but was absent in CD24- adjacent normal cells. The correlation between ANXA10 expression and the progression of pancreatic cancer remains unknown. In this study, we performed an immunostaining assay to evaluate ANXA10 expression in 155 primary human tissue specimens, including normal pancreas, chronic pancreatitis (CP), pancreatic adenocarcinoma (PDAC), pancreatic intraepithelial neoplasia (PanIN, the most important precursor of PDAC), and intraductal papillary mucinous neoplasm (IPMN). The immunostaining result showed that ANXA10 was significantly overexpressed in PanINs, IPMNs, and PDACs but negative in normal pancreas and the majority of chronic pancreatitis tissues. Statistical analysis revealed that ANXA10 expression was significantly associated with PDAC and its precursor lesions (p<0.0001). Abundant ANXA10 expression was predominantly present in pancreatic ductal epithelial cells of PanINs, IPMNs, and tumor cells of PDACs. Since PDAC develops through a series of PanINs which in turn arise from pancreatic ducts, the consistent overexpression of ANXA10 in ductal epithelial cells in PanINs and PDACs but negative in normal pancreatic ducts suggests that ANXA10 could serve as a potential marker indicating the presence of PDAC at its earliest precancerous stages. Double immunostaining of ANXA10 and CD24 showed that there was a large overlap between these two markers in PDAC and high-grade neoplasia lesions. The statistical analysis showed that the coexpression of ANXA10 and CD24 was significantly correlated with the progression of pancreatic precursor lesions towards PDACs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Annexin A10 is a candidate marker associated with the progression of pancreatic precursor lesions to adenocarcinoma

Zhu

Pei

et al. 2017

PLoS ONE

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“…26 MUC6 has a cytoprotective role in forming a mucous barrier against hostile gastric acid. 27 As ANXA10 was characterized to have a role in gastric gland development and maintenance, 14 it was not surprised that ANXA10 expression was highly associated with MUC5AC and MUC6 positivity. Yao et al 28 first described gastric differentiation in serrated adenoma in 1999.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, we have shown that ANXA10 is a protein specifically expressed in the gastric mucosa, the Brunner gland of the duodenum and the urothelium. 14,15 The upregulation of ANXA10 in sessile serrated adenoma may indicate an aberrant gastric phenotype in colonic serrated neoplasia; as evidenced by the high expression of gastric foveolar (MUC5AC) and pyloric mucin (MUC6) in sessile serrated adenoma. 16,17 Colorectal cancers exhibiting molecular features related to serrated neoplasia pathways are closely associated with MUC5AC and MUC6 expression, 18 implying that gastric programming participates in the carcinogenesis of a subset of colorectal cancers.…”

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confidence: 99%

Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma

et al. 2015

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Annexin A10 (ANXA10) is a member of the ANX family that is normally expressed in gastric mucosa. ANXA10 was recently observed to be upregulated in sessile serrated adenoma, a precursor to microsatellite-unstable colorectal cancer. We investigated the use of ANXA10 in diagnosing colorectal carcinoma. In an immunohistochemical analysis, the intensity and quantity of ANXA10, MUC5AC, MUC6 and CDX2 in 123 colorectal carcinomas were graded. We determined the molecular status of BRAF and KRAS mutations, as well as the microsatellite instability status and the CpG island methylator phenotype in all colorectal carcinomas, and subcategorized into four molecular subgroups according to the molecular derangements. Nuclear ANXA10 staining was present in 36 colorectal carcinomas, exhibiting a strong significant association with the BRAF mutation status (Po0.0001) and positive CpG island methylator phenotype (Po0.0001), and a borderline significant association with high levels of microsatellite instability (P ¼ 0.072). The ANXA10-positive colorectal carcinomas were frequently positive for MUC5AC and MUC6, and were associated with absent or reduced CDX2 expression (all Po0.0001). According to a classification and regression tree analysis, ANXA10 is a superior marker for the molecular subtyping of colorectal carcinomas and represents a specific marker for colorectal cancers of the serrated pathway. Our results indicated that ANXA10 expression is implicated in gastric programming in serrated-pathway-associated colorectal carcinoma. ANXA10-positive colorectal carcinoma is highly associated with the molecular features of the serrated neoplasia pathway.

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“…Annexin A10 is a nuclear annexin specifically expressed in foetal and adult gastric mucosa (Lu et al, 2011). It is down-regulated in gastric carcinoma .…”

Section: Tissue Distribution and Intracellular Localization Of Annexinsmentioning

confidence: 99%

Regulation of Lysosomal Degradation by CA2+And CA2+-Binding Proteins

Cherfaoui¹

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Expression and prognostic significance of gastric‐specific annexin A10 in diffuse‐ and intestinal‐type gastric carcinoma

Abstract: The ANXA10 protein expression is a novel marker of gastric differentiation, and is differentially expressed in IGC and DGC, with opposite prognostic significance.

Cited by 19 publications

References 45 publications

Annexin A10 is a candidate marker associated with the progression of pancreatic precursor lesions to adenocarcinoma

Annexin A10 is a candidate marker associated with the progression of pancreatic precursor lesions to adenocarcinoma

Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma

Regulation of Lysosomal Degradation by CA2+And CA2+-Binding Proteins

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