Expression and prognostic significance of catalase in malignant mesothelioma

Kahlos, Katriina; Soini, Ylermi; Sormunen, Raija; Kaarteenaho‐Wiik, Riitta; Pääkkö, Paavo; Linnainmaa, Kaija; Kinnula, Vuokko L.

doi:10.1002/1097-0142(20010401)91:7<1349::aid-cncr1138>3.0.co;2-d

Cited by 35 publications

(21 citation statements)

References 41 publications

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“…According to el Bouhtoury et al [59], CATA frequently displays inadequate levels of expression in several malignancies. However, our findings are in line with several previous studies suggesting up-regulation of catalase in malignant mesothelioma tumors [60], childhood and adult de novo AML [21,58], as well as childhood t-AML [37]. …”

Section: Discussionsupporting

confidence: 93%

Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner

et al. 2013

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The current study evaluated the differential expression detected in the proteomic profiles of low risk- and high risk- ALL pediatric patients to characterize candidate biomarkers related to diagnosis, prognosis and patient targeted therapy. Bone marrow and peripheral blood plasma and cell lysates samples were obtained from pediatric patients with low- (LR) and high-risk (HR) ALL at diagnosis. As controls, non-leukemic pediatric patients were studied. Cytogenetic analysis was carried out by G- banding and interphase fluorescent in situ hybridization. Differential proteomic analysis was performed using two-dimensional gel electrophoresis and protein identification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The differential expression of certain proteins was confirmed by Western blot analysis. The obtained data revealed that CLUS, CERU, APOE, APOA4, APOA1, GELS, S10A9, AMBP, ACTB, CATA and AFAM proteins play a significant role in leukemia prognosis, potentially serving as distinctive biomarkers for leukemia aggressiveness, or as suppressor proteins in HR-ALL cases. In addition, vitronectin and plasminogen probably contributed to leukemogenesis, whilst bicaudal D-related protein 1 could afford a significant biomarker for pediatric ALL therapeutics.

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Section: Discussionsupporting

confidence: 93%

Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner

et al. 2013

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“…Queuine treatment of the DLAT cancerous mouse gradually improves catalase activity. The activity of catalase is reported to be low in Morris hepatomas, Lewis lung carcinomas and the tumorigenic hamster kidney, as well as in various tumour cells and human cancers [52,53]. In mammalian cells, the catalase monomer binds to one molecule of haem; the holoenzyme also binds to two molecules of NADPH and maintains catalase in an active state.…”

Section: Discussionmentioning

confidence: 99%

Queuine promotes antioxidant defence system by activating cellular antioxidant enzyme activities in cancer

2008

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Constant generation of Reactive oxygen species (ROS) during normal cellular metabolism of an organism is generally balanced by similar rate of consumption by antioxidants. Imbalance between ROS production and antioxidant defense results in increased level of ROS causing oxidative stress which leads to promotion of malignancy. Queuine is a hyper modified base analogue of guanine, found at first anti-codon position of Q- family of tRNAs. These tRNAs are completely modified with respect to queuosine in terminally differentiated somatic cells, however hypomodification of Q-tRNAs is close association with cell proliferation. Q-tRNA modification is essential for normal development, differentiation and cellular functions. Queuine is a nutrient factor to eukaryotes. It is found to promote cellular antioxidant defense system and inhibit tumorigenesis. The activities of antioxidant enzymes like catalase, SOD, glutathione peroxidase and glutathione reductase are found to be low in Dalton's lymphoma ascites transplanted (DLAT) mouse liver compared to normal. However, exogenous administration of queuine to DLAT mouse improves the activities of antioxidant enzymes. The results suggest that queuine promotes antioxidant defense system by increasing antioxidant enzyme activities and in turn inhibits oxidative stress and tumorigenesis.

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“…These experiments, which modulated catalase activity, suggest that catalase alone does not appear to play a pivotal role in protecting PC3 cells from doxorubicin exposure, and that the redox event associated with the drug is more complex. Similarly, it has been observed that aminotriazole inhibition of catalase did not alter epirubicin-cytotoxicity in a major way for the M38K mesothelioma cell line [39].…”

Section: Discussionmentioning

confidence: 99%

Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells

Wagner¹,

Evig²,

Reszka³

et al. 2005

Archives of Biochemistry and Biophysics

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We studied the effect of doxorubicin on the production of hydrogen peroxide by PC3 human prostate cancer cells, using a sensitive assay based on aminotriazole-mediated inhibition of catalase. PC3 cells exposed to increasing concentrations of doxorubicin had an increase in intracellular hydrogen peroxide that was concentration-dependent up to 1 μM doxorubicin. The apparent hydrogen peroxide concentration in the PC3 cells was 13 ± 4 pM under basal steady-state conditions and increased to 51 ± 13 pM after exposure to 1 μM doxorubicin for 30 min. The level of hydrogen peroxide in the medium as measured by Amplex Red did not increase as a result of doxorubicin treatment. PC3 cells overexpressing catalase were no more resistant to doxorubicin cytotoxicity as compared to non-transduced wild-type cells; therefore, the exact role of hydrogen peroxide in anthracycline cytotoxicity remains unproven. This study demonstrates that a specific oxidative event associated with the exposure of PC3 human prostate cancer cells to anthracyclines results in an increase in intracellular hydrogen peroxide. KeywordsHydrogen peroxide; Doxorubicin; PC3 cells; Catalase; Transduction; Amplex Red; Oxidative stress; Aminotriazole; Fluorescent probes; Reactive oxygen species There are reports that suggest that anthracycline anti-cancer drugs may increase the intracellular production of hydrogen peroxide. The metabolic reductive activation of doxorubicin to a semiquinone (Eq. 1) stimulates production of superoxide by the oneelectron reduction of oxygen (Eq. 2) [1]. The dismutation of the resulting superoxide,

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Expression and prognostic significance of catalase in malignant mesothelioma

Cited by 35 publications

References 41 publications

Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner

Protein biomarkers distinguish between high- and low-risk pediatric acute lymphoblastic leukemia in a tissue specific manner

Queuine promotes antioxidant defence system by activating cellular antioxidant enzyme activities in cancer

Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells

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