Expression and regulation of CCN genes in murine osteoblasts

WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling

“…These counterintuitive and seemingly contradictory findings emphasize the complexity of CCN2 function, which appears to work differentially pre-and postnatally and could furthermore be de- pendent on the fine-tuning of CCN2 expression in specific cell types. Like CCN2, Nov/CCN3 is expressed in skeletal cells (16), with functions that appear to be equally complex. Total depletion of CCN3 in mice causes prenatal mild skeletal defects that are proposed to arise from accelerated osteoblast differentiation (17).…”

Nephroblastoma Overexpressed (Nov) Inhibits Osteoblastogenesis and Causes Osteopenia

“…Former studies have shown that cells of the osteoblastic lineage express transcripts for Nov and other members of the CCN family of proteins (61). However, the function of Nov in skeletal cells has not been established.…”

Connective tissue growth factor is expressed in bone marrow stromal cells and promotes interleukin-7-dependent B lymphopoiesis

“…For example, CTGF is secreted by osteoblastic cells, which are known to play a critical role in hematopoietic stem cell niches, and in vitro studies using recombinant CTGF suggested that CTGF enhances proliferation and differentiation of these cells. 14,15,[18][19][20] Apart from its physiological roles, CTGF has been implicated in fibrosis and cancer. Hematopoiesis occurs in a complex bone marrow microenvironment in which bone marrow stromal cells provide critical support to the process through direct cell contact and indirectly through the secretion of cytokines and growth factors.…”