Expression and regulation of the decoy bone morphogenetic protein receptor <i>BAMBI</i> in the developing avian face

Higashihori, Norihisa; Song, Yiping; Richman, Joy M.

doi:10.1002/dvdy.21529

Cited by 20 publications

(19 citation statements)

References 112 publications

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“…Several BMPs (BMP2, BMP4, BMP7) and BMP antagonists (NOGGIN, BAMBI) are expressed in the epithelium and mesenchyme of the frontonasal mass, in some cases overlapping with TBX22 and other times in complementary domains (Francis-West et al, 1994;Ashique et al, 2002a;Foppiano et al, 2007;Higashihori et al, 2008). From these data, it is not possible to predict whether increased or decreased levels of BMP signaling affect TBX22 expression.…”

Section: Regulation Of Tbx22 By Bmpsmentioning

confidence: 99%

The function and regulation of TBX22 in avian frontonasal morphogenesis

Higashihori¹,

Buchtová²,

Richman³

2010

Developmental Dynamics

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The frontonasal mass gives rise to the facial midline and fuses with the maxillary prominence to form the upper lip. Here we focus on the regulation and function of TBX22, a repressor dynamically expressed in the frontonasal mass. Both FGF and Noggin (a BMP antagonist) strongly induce gTBX22, however, each has opposite effects on morphogenesis -Noggin inhibits whereas FGF stimulates growth. To determine whether TBX22 mediates these effects, we used retroviruses to locally increase expression levels. RCAS::hTBX22 decreased proliferation, reduced expression of MSX2 and DLX5 and caused cleft lip. Decreased levels of endogenous gTBX22 were also observed but were not the primary cause of the phenotype as determined in rescue experiments. Our data suggest that genetic or environmental insults such as those affecting the BMP pathway could lead to a gain-of-function of TBX22 and predispose an individual to cleft lip. Developmental Dynamics 239:458-473,

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Section: Regulation Of Tbx22 By Bmpsmentioning

confidence: 99%

The function and regulation of TBX22 in avian frontonasal morphogenesis

Higashihori¹,

Buchtová²,

Richman³

2010

Developmental Dynamics

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“…BAMBI is incorporated into complexes with TGF-β/BMP/activin type-2 receptors (TGFR2/BMPR2) and, as a pseudoreceptor, antagonizes all TGF-β/BMP and activin signaling. 10, 11 BAMBI is tightly co-expressed with BMP4 during embryonic development in zebrafish, Xenopus , birds and mice 10, 12, 13, 14 through TGF-β 15 and Wnt signaling. 16 …”

Section: Introductionmentioning

confidence: 99%

C-terminal-truncated HBV X promotes hepato-oncogenesis through inhibition of tumor-suppressive β-catenin/BAMBI signaling

Lee

Zhang

et al. 2016

Exp Mol Med

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C-terminal-truncated hepatitis B virus (HBV) X (HBx) (ctHBX) is frequently detected in hepatocellular carcinoma (HCC) through HBV integration into the host genome. However, the molecular mechanisms underlying ctHBx-associated oncogenic signaling have not yet been clarified. To elucidate the biological role of ctHBx in hepato-oncogenesis, we functionally analyzed ctHBx-mediated regulation of the activin membrane-bound inhibitor bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) through transforming growth factor-β (TGF-β) or β-catenin (CTNNB1) in HCC cells and in an animal model, and we compared its role to that of the full-length HBx protein. Ectopic ctHBx expression generated more colonies in anchorage-dependent and -independent growth assays than did HBx expression alone. ctHBx downregulated BAMBI to a greater degree than did HBx in HCC cells. HBx activated the Wnt/β-catenin pathway, which positively regulated the BAMBI expression through T-cell factor 1 signaling, whereas ctHBx negatively regulated the Wnt/β-catenin pathway. BAMBI downregulated the β-catenin and TGF-β1 signaling pathways. TGF-β1 positively regulated BAMBI expression thorough Smad3 signaling. Furthermore, knockdown of BAMBI was more tumorigenic in HCC cells. Therefore, downregulation of both β-catenin and TGF-β1 signaling by BAMBI might contribute to tumor suppression in mice xenotransplanted with HepG2 or SH-J1 cells. Taken together, ctHBx may have a more oncogenic role than HBx through its inhibition of tumor-suppressive β-catenin/BAMBI signaling.

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“…It has been documented that Xenopus BAMBI functions as a general antagonist for TGF-␤ family members (TGF-␤, activin, and BMP) by acting as a pseudoreceptor to block the interaction of signaling type I and type II receptors (18). BAMBI is tightly coexpressed with BMP during development in Xenopus, mouse, and zebrafish (18,20,21,23,24), and its expression is induced by BMP4 (18, 24), TGF-␤ (25), ␤-catenin (17), lipopolysaccharide (26), and retinoic acid (23).Several studies have suggested that BAMBI is involved in pathogenesis of various kinds of human diseases. The human BAMBI, initially named as nma, is down-regulated in metastatic melanoma cell lines (22), and has been implicated to promote cell growth and invasion in human gastric carcinoma cell lines (27).…”

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confidence: 99%

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The Pseudoreceptor BMP and Activin Membrane-bound Inhibitor Positively Modulates Wnt/β-Catenin Signaling

Lin

Gao

Ning

et al. 2008

Journal of Biological Chemistry

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The canonical Wnt/␤-catenin pathway plays a pivotal role in regulating embryogenesis and tumorigenesis by promoting cell proliferation. BAMBI (BMP and activin membrane-bound inhibitor) has previously been shown to negatively regulate the signaling activity of transforming growth factor-␤, activin, and BMP and was identified as a target of ␤-catenin in colorectal and hepatocellular tumor cells. In this study, we provide evidence that BAMBI can promote the transcriptional activity of Wnt/␤-catenin signaling. Overexpression of BAMBI enhances the expression of Wnt-responsive reporters, whereas knockdown of endogenous BAMBI attenuates them. Accordingly, BAMBI also promotes the nuclear translocation of ␤-catenin. BAMBI interacts with Wnt receptor Frizzled5, coreceptor LRP6, and Dishevelled2 and increases the interaction between Frizzled5 and Dishevelled2. Finally we show that BAMBI promotes the expression of c-myc and cyclin D1 and increases Wnt-promoted cell cycle progression. Altogether, our data indicate that BAMBI can function as a positive regulator of the Wnt/␤-catenin pathway to promote cell proliferation.Wnt signaling is initiated by binding to its seven-transmembrane receptor, Frizzled (Fzd), 2 and single-span transmembrane coreceptor low density lipoprotein receptor-related protein 5 and 6 (LRP5/6) (1-4). Dishevelled (Dvl) and ␤-catenin play an essential role in the canonical Wnt signaling. In the absence of Wnt proteins, ␤-catenin is phosphorylated (5-11) and ubiquitinated and then targeted for proteasome-mediated degradation by a cytoplasmic destruction complex consisting of adenomatous polyposis coli, Axin, glycogen synthase kinase 3␤ (GSK3␤), and casein kinase 1. The binding of Wnt ligands to the receptors results in the recruitment of Dvl to the plasma membrane and therefore the disassembly of the destructive complex, leading to the accumulation and nuclear translocation of ␤-catenin, which collaborates with the transcription factors of the lymphoid enhancer-binding factor (LEF)/T-cell factor (TCF) family and activates the transcription of Wnt target genes.The Wnt signaling pathway plays key roles in embryogenesis and adult homeostasis and is aberrantly activated in various human cancers (3, 4). For instance, in most of colorectal cancers, ␤-catenin is stabilized and accumulated in the nucleus and constitutively activates its target genes (12, 13). A wide spectrum of ␤-catenin targets, such as the proteins involved in cell cycle, cell-matrix interactions, migration, and invasion, has been identified (14 -16). One of such targets is BAMBI (BMP and activin membrane-bound inhibitor), which has been found to be directly up-regulated by the functional ␤-catenin-TCF4 complex in colorectal tumor cells (17).The BAMBI gene encodes a 260-amino acid transmembrane protein that is evolutionally conserved in vertebrates, from fish to human (18 -22). The BAMBI protein is closely related to type I receptors of the transforming growth factor-␤ (TGF-␤) family in the extracellular domain but has a short intracellular doma...

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Expression and regulation of the decoy bone morphogenetic protein receptor BAMBI in the developing avian face

Cited by 20 publications

References 112 publications

The function and regulation of TBX22 in avian frontonasal morphogenesis

The function and regulation of TBX22 in avian frontonasal morphogenesis

C-terminal-truncated HBV X promotes hepato-oncogenesis through inhibition of tumor-suppressive β-catenin/BAMBI signaling

The Pseudoreceptor BMP and Activin Membrane-bound Inhibitor Positively Modulates Wnt/β-Catenin Signaling

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