Expression and regulation of the differentiation regulators ERBB Receptor Feedback Inhibitor 1 (ERRFI1) and Interferon‐related Developmental Regulator 1 (IFRD1) during the periovulatory period in the rat ovary

Li, Fei-xue; Liu, Ying; Miao, Xiaoping; Fu, Guoquan; Curry, Thomas E.

doi:10.1002/mrd.22673

Cited by 9 publications

(5 citation statements)

References 52 publications

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“…3). This is in contrast to a study in female Sprague-Dawley rats, where increased expression of IFRD1 was found in granulosa cells and cumulus oocyte complexes after administration of human chorionic gonadotropin (to mimic the LH-surge and induce ovulation), indicating potential involvement of IFRD1 in oocyte maturation (Li et al, 2016). However, this study was performed in a different time frame (hours) and on single cells compared with weeks and ovary homogenates, respectively, in our study.…”

Section: Ovarycontrasting

confidence: 99%

Fine-tuning of seasonal timing of breeding is regulated downstream in the underlying neuro-endocrine system in a small songbird

Verhagen

Laine

Mateman

et al. 2019

Journal of Experimental Biology

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The timing of breeding is under selection in wild populations as a result of climate change, and understanding the underlying physiological processes mediating this timing provides insight into the potential rate of adaptation. Current knowledge on this variation in physiology is, however, mostly limited to males. We assessed whether individual differences in the timing of breeding in females are reflected in differences in candidate gene expression and, if so, whether these differences occur in the upstream (hypothalamus) or downstream (ovary and liver) parts of the neuroendocrine system. We used 72 female great tits from two generations of lines artificially selected for early and late egg laying, which were housed in climatecontrolled aviaries and went through two breeding cycles within 1 year. In the first breeding season we obtained individual egg-laying dates, while in the second breeding season, using the same individuals, we sampled several tissues at three time points based on the timing of the first breeding attempt. For each tissue, mRNA expression levels were measured using qPCR for a set of candidate genes associated with the timing of reproduction and subsequently analysed for differences between generations, time points and individual timing of breeding. We found differences in gene expression between generations in all tissues, with the most pronounced differences in the hypothalamus. Differences between time points, and early-and late-laying females, were found exclusively in the ovary and liver. Altogether, we show that finetuning of the seasonal timing of breeding, and thereby the opportunity for adaptation in the neuroendocrine system, is regulated mostly downstream in the neuro-endocrine system.

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Section: Ovarycontrasting

confidence: 99%

Fine-tuning of seasonal timing of breeding is regulated downstream in the underlying neuro-endocrine system in a small songbird

Verhagen

Laine

Mateman

et al. 2019

Journal of Experimental Biology

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“…However, studies in rats showed the link between obesity and the lack of a preovulatory surge of progesterone and LH which consequently causes a decrease in the expression of the Edn2 gene [ 36 ]. Errfi1 may be important for theca and granulosa cell differentiation and the cumulus–oophorus complex (COC) expansion [ 125 ]. Tnfaip6 is involved in forming the extracellular matrix (ECM) during cumulus mucification.…”

Section: High-fat Diet Affecting Ovarian Folliculogenesismentioning

confidence: 99%

High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

et al. 2022

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Female reproduction focuses mainly on achieving fully grown follicles and competent oocytes to be successfully fertilized, as well as on nourishing the developing offspring once pregnancy occurs. Current evidence demonstrates that obesity and/or high-fat diet regimes can perturbate these processes, leading to female infertility and transgenerational disorders. Since the mechanisms and reproductive processes involved are not yet fully clarified, the present review is designed as a systematic and comparative survey of the available literature. The available data demonstrate the adverse influences of obesity on diverse reproductive processes, such as folliculogenesis, oogenesis, and embryo development/implant. The negative reproductive impact may be attributed to a direct action on reproductive somatic and germinal compartments and/or to an indirect influence mediated by the endocrine, metabolic, and immune axis control systems. Overall, the present review highlights the fragmentation of the current information limiting the comprehension of the reproductive impact of a high-fat diet. Based on the incidence and prevalence of obesity in the Western countries, this topic becomes a research challenge to increase self-awareness of dietary reproductive risk to propose solid and rigorous preventive dietary regimes, as well as to develop targeted pharmacological interventions.

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“…The expression of IFRD1, a gene proposed to be involved in regulation of cell proliferation and differentiation (Vadivelu et al 2004;Vietor & Huber 2007), decreased in time point 3 compared to time point 1 for all females, as in Chapter 4, but significantly for the early egg-laying females ( Figure 5.3) . This is in contrast with a study in female Sprague-Dawley rats, where increased expression of IFRD1 was found in granulosa cells and cumulus oocyte complexes after administration of human chorionic gonadotropin (to mimic the LH-surge and induce ovulation), indicating potential involvement of IFRD1 in oocyte maturation (Li et al 2016). However, this study was performed in a different time frame (hours) and on single cells compared to weeks and ovary homogenates, respectively in our study.…”

Section: Ovarycontrasting

confidence: 93%

The mechanisms underlying seasonal timing of breeding : a multi-level approach using bi-directional genomic selection on timing of egg-laying

Verhagen¹

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Table of contents Chapter 1 General introduction Chapter 2 Genetic and phenotypic responses to genomic selection for timing of breeding in a wild songbird Chapter 3 Temperature has a causal and plastic effect on timing of breeding in a small songbird Chapter 4 Exploration of tissue-specific gene expression patterns underlying timing of breeding in contrasting temperature environments in a songbird Chapter 5 Fine-tuning of seasonal timing of breeding is regulated downstream in the underlying neuro-endocrine system in a small songbird Chapter 6 Exploring temporal changes in DNA methylation and RNA expression in a small songbird-correlations within and between tissues Chapter 7 General discussion References Summary Samenvatting Curriculum vitae List of publications Acknowledgements WIAS Training and Education Statement CHAPTER 1 General introduction Chapter 1 10 Evolution and natural selection Evolution, the process that leads to the formation of and change in biological systems in response to their environment, has shaped life since its beginning and continues to do so. All organisms, simple and complex, evolve over different scales in both time and space. In general, evolution is described and studied as two distinct hierarchical processes; macroevolution and micro-evolution. Macro-evolution refers to the origin of new morphological forms, species and divisions of the taxonomic hierarchy above the species level, together with the origin of complex adaptations, such as the eye (Reznick & Ricklefs 2009), but on which I will not dwell further. In contrast, micro-evolution refers to the processes of adaptive modifications (i.e. through alteration in allele frequencies in gene pools) within and among populations, propelled by mutation, migration, genetic drift and natural selection. The latter, put first into words by, independently, both Charles Darwin (1859) and Alfred Russel Wallace (1858), is usually defined as the consequence of three organismal properties: (1) variation among organisms of a population, (2) differential reproduction, and (3) traits that are important for survival or reproduction show heritability (Darwin 1859; Wallace 1858).

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Expression and regulation of the differentiation regulators ERBB Receptor Feedback Inhibitor 1 (ERRFI1) and Interferon‐related Developmental Regulator 1 (IFRD1) during the periovulatory period in the rat ovary

Cited by 9 publications

References 52 publications

Fine-tuning of seasonal timing of breeding is regulated downstream in the underlying neuro-endocrine system in a small songbird

Fine-tuning of seasonal timing of breeding is regulated downstream in the underlying neuro-endocrine system in a small songbird

High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models

The mechanisms underlying seasonal timing of breeding : a multi-level approach using bi-directional genomic selection on timing of egg-laying

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