Expression and Role of TRIM2 in Human Diseases

Abstract

Tripartite motif (TRIM) protein family proteins contain more than 80 members in humans, and most of these proteins exhibit E3 ubiquitin ligase activity mediated through a RING finger domain. Their biological functions are very complex, and they perform diverse functions in cell evolution processes, such as intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy, and carcinogenesis. Tripartite motif-containing protein 2 (TRIM2), a member of the TRIM superfamily, is an 81 kDa multidomain protein, also known as CMT2R or RNF86, located at 4q31.3. TRIM2 functions as an E3 ubiquitin ligase. Current studies have shown that TRIM2 can play roles in neuroprotection, neuronal rapid ischemic tolerance, antiviral responses, neurological diseases, etc. Moreover, based on some studies in tumors, TRIM2 regulates tumor proliferation, migration, invasion, apoptosis, and drug resistance through different mechanisms and plays a critical role in tumor occurrence and development. This review is aimed at providing a systematic and comprehensive summary of research on TRIM2 and at exploring the potential role of TRIM2 as a biomarker and therapeutic target in many kinds of human diseases.

CircORC2 promoted proliferation and inhibited the sensitivity of osteosarcoma cell lines to cisplatin by regulating the miR‐485‐3p/TRIM2 axis

“…TRIM2 is an 81 kDa multidomain protein, also known as CMT2R or RNF86, located at 4q31.3. 36 It is an important gene involved in the pathogenic process of cancer via different mechanisms and in different microenvironments. 37 Qing et al reported that TRIM2 regulates the occurrence and metastasis of OS through the phosphoinositide 3 kinase/protein kinase B signal pathway.…”

“…This study elucidated the targeting relationships between circORC2, miR‐485‐3p, and TRIM2 and the specific mechanisms by which they regulate DDP resistance in OS. TRIM2 is an 81 kDa multidomain protein, also known as CMT2R or RNF86, located at 4q31.3 36 . It is an important gene involved in the pathogenic process of cancer via different mechanisms and in different microenvironments 37 .…”

“…TRIM2 is an 81 kDa multidomain protein, also known as CMT2R or RNF86, located at 4q31.3. 36 It is an important gene involved in the pathogenic process of cancer via different mechanisms and in different microenvironments. 37 Qing et al.…”

Tripartite Motif-Containing 2, a Glutamine Metabolism-Associated Protein, Predicts Poor Patient Outcome in Triple-Negative Breast Cancer Treated with Chemotherapy

“…TRIM2 is an 81 kDa multi-domain protein, and the gene is located at 4q31.3 [ 9 , 10 ]. TRIM proteins, one of the subfamilies of the RING-type E3 ubiquitin ligases, are involved in a broad range of biological processes, and their alterations are associated with disease incidence and progression relevant to the development of common cancer [ 9 , 11 ]. Several members of the TRIM family have previously been implicated as either tumour suppressors or oncogenes in BC, including TRIM16, TRIM24, TRIM32, TRIM33, TRIM45, TRIM47, and TRIM59 [ 12 ].…”

Spectrinopathies in rare neurological and neuromuscular diseases : large-scale efforts towards the identification of novel molecular causes

“…Multiple genes that encode E3 ubiquitin ligases, which tag proteins to be degraded with ubiquitin, are linked to IPN. Examples include RNF170, LRSAM1, and TRIM2 [61][62][63] . Linked to this, heat shock proteins are produced in the cell in response to stressful conditions, such as heat, cold, UV light or wound healing.…”