Expression and Significance of Cadherins and Its Subtypes in Development and Progression of Oral Cancers: A Review

Rajwar, Yogesh Chand; Jain, Nitul; Bhatia, Gouri; Sikka, Neha; Garg, Balram; Walia, Esha

doi:10.7860/jcdr/2015/11964.5907

Cited by 24 publications

(20 citation statements)

References 11 publications

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“…We hypothesize that cell adhesion forces maintain the morphology of these rod-like constructs. Cadherins and desmosomes are well-known cell-cell adhesion proteins; 28,29 furthermore, it has been reported that integrins and hemidesmosomes work as cell-ECM adhesion proteins. 30,31 Our histological analysis did not find abundant ECM deposition in these constructs, indicating that cell-cell adhesion molecules such as E-cadherin maintained construct morphology, even after syringe processing.…”

Section: Discussionmentioning

confidence: 99%

Fabricating large‐scale three‐dimensional constructs with living cells by processing with syringe needles

Sasaki

Katata

Abe

et al. 2019

J Biomedical Materials Res

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Three‐dimensional (3D) cell constructs composed only of cells and cell‐secreted extracellular matrix have been attractive biomaterials for tissue engineering technology; however, controlling construct morphology and eliminating dead cells after fabrication remain a challenge. It has been hypothesized that moderate stress could shape constructs and eliminate dead cells. The purpose of this study was to establish an easily available technology for shaping 3D cell constructs and eliminating dead cells postfabrication. To achieve these objectives, spherical cell constructs composed of L‐929 fibroblasts were processed using different sized syringe needles. Our results revealed that large‐scale rod‐shaped cell constructs could be fabricated, and that their diameters could be controlled according to the size of the syringe needle. Additionally, cell viability assays showed that >94% of cells in the rod‐shaped constructs were viable, suggesting that dead cells, which have low adhesion force, were dispersed when compressive stress was applied during passage through the needle. The technology described in this study will be promising for future tissue engineering, especially for fabricating elongated tissues such as nerves and blood vessels. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 904–909, 2019.

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Section: Discussionmentioning

confidence: 99%

Fabricating large‐scale three‐dimensional constructs with living cells by processing with syringe needles

Sasaki

Katata

Abe

et al. 2019

J Biomedical Materials Res

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“…Oral cancer is one of the most common malignancies in head and neck that de ned as any cancerous tissue growth located in the oral cavity [1]. According to the American Cancer Society, approximately 45,780 new cases and 8,650 cancer deaths attributed to this condition occur in 2015 in United States [2] Approximately 90% of oral neoplasms are oral squamous cell carcinoma (OSCC), most of which are invasive growth, invasion of surrounding tissue and easy to occur lymph node metastasis [3,4].…”

Section: Introductionmentioning

confidence: 99%

Relationship of Common Variants in miR-27a-3p Gene with Susceptibility and Prognosis of Oral Cancer

Wang¹,

Song²,

Yang³

2020

Preprint

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Background: miR-27a-3p has been found dysexpressed in various cancers. The aim of the present study was to clarify the prognostic value of miR-27a-3p in patients with oral cancer.Methods: We used quantitative real-time polymerase chain reaction (qRT-PCR) assay to detect the expression of miR-27a-3p in the tissue of oral cancer and adjacent normal specimens. The association of miR-27a-3p with clinicopathological characteristics was analyzed via the Chi-square test. Kaplan-Meier survival and Cox regression analysis were performed to evaluate the prognostic value of miR-27a-3p in oral cancer patients.Results: The down-regulated expression of miR-27a-3p was found in oral cancer tissues compared with the matched noncancerous samples (P<0.05). And its expression was influenced by TNM stage (P=0.032), T stage (P=0.014) and lymph node metastasis (P=0.025). Kaplan–Meier analysis result showed that the decreased level of miR-27a-3p expression was associated with a poor overall survival of oral cancer patients. Additionally, multivariate cox regression analysis revealed that the low expression of miR-27a-3p was an independent prognostic maker in oral cancer patients (HR=0.462, 95% CI=0.223-0.957, P=0.038).Conclusions: Taken together, the expression pattern of miR-27a-3p was decreased in oral cancer tissues. The decreased expression of miR-27a-3p was a potential prognostic biomarker in patients with oral cancer.

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“…[3] It is mainly expressed on epithelial cells and behaves as both receptor and ligand for other molecules and can be used as a marker for epithelial differentiation owing to limited expression to the cells of epithelial origin. In addition to that, E-cadherin has a major role in the morphogenesis of cells during migration and acts as tumor suppressor gene [4,5]. In some solid tumors, such as breast cancer, loss of E-cadherin function is often associated with tumor progression and transition to more invasive disease [6].…”

Section: E-cadherinmentioning

confidence: 99%

E-cadherin Immunohistochemistry Stain and Acute Erythroid Leukemia, the Emerging Story

2015

J Cytol Histol

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E-Cadherin is calcium-dependent cell adhesion molecule encoded by CDH1 gene at chromosome 16q22.1. Ecadherin regulates cell-cell adhesions and controls mobility and proliferation of epithelial cells. Recently, the role of E-cadherin in erythroid maturation has been elucidated. It is selectively expressed in immature erythroblasts and gradually down regulated as erythroid precursors mature. Acute erythroid leukemia is neoplastic proliferation of immature erythroid precursors in bone marrow with or without significant myeloblasts component. In the recent years E-cadherin has emerged as the most sensitive and specific marker for immature erythroblasts. Moreover, combination of E-cadherin with glycophorin A in immunohistochemistry staining can effectively separate immature vs. mature erythroid precursors in bone marrow biopsy. In this short review I will shed light on the key points related to the nature of relationship between E-cadherin and acute erythroid leukemia.

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Expression and Significance of Cadherins and Its Subtypes in Development and Progression of Oral Cancers: A Review

Cited by 24 publications

References 11 publications

Fabricating large‐scale three‐dimensional constructs with living cells by processing with syringe needles

Fabricating large‐scale three‐dimensional constructs with living cells by processing with syringe needles

Relationship of Common Variants in miR-27a-3p Gene with Susceptibility and Prognosis of Oral Cancer

E-cadherin Immunohistochemistry Stain and Acute Erythroid Leukemia, the Emerging Story

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