2015
DOI: 10.3390/ijms16023391
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Expression and Significance of CD44, CD47 and c-met in Ovarian Clear Cell Carcinoma

Abstract: Aims: The aim of the present study is to investigate the differential expression of CD44, CD47 and c-met in ovarian clear cell carcinoma (OCCC), the correlation in their expression and their relationship with the biological behavior of OCCC. Methods: We used immunohistochemistry to examine the expression of CD44, CD47 and c-met in OCCC (86 cases) and investigated the effects of the expression and interaction of these molecules on the development of OCCC. Results: CD44, CD47 and c-met expression was significant… Show more

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Cited by 68 publications
(63 citation statements)
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“…As a matter of fact, abnormal expression of CD47 has been found in hematopoietic stem cells and leukemia cells, human acute myeloid leukemia stem cells, hepatocellular carcinoma, ovarian clear cell carcinoma [19][20][21][22], etc. displaying that CD47 might be a prevalent marker in many types of cell, including cancer cell.…”
Section: Discussionmentioning
confidence: 99%
“…As a matter of fact, abnormal expression of CD47 has been found in hematopoietic stem cells and leukemia cells, human acute myeloid leukemia stem cells, hepatocellular carcinoma, ovarian clear cell carcinoma [19][20][21][22], etc. displaying that CD47 might be a prevalent marker in many types of cell, including cancer cell.…”
Section: Discussionmentioning
confidence: 99%
“…Similar to other epithelial cancers, cell adhesion molecules must play a role in the progression of ovarian cancer, especially since aberrant expression of various CAMs, such as mucins [11], integrins [12], CD44 [13], L1CAM [14], cadherin [15], claudins [16], EpCAM [17], ALCAM [18] and METCAM/MUC18 [19,20], has been associated with the malignant progression of ovarian cancer. Some of the CAMs may play a positive role, such as MUC4 [21], CD44 [22], L1CAM [23], ALCAM [18], and P-cadherin [24]; however, some a negative role, such as β3-integrin [25], E-cadherin [26], claudin-3, 4, &7 [27], EpCAM [28], and KAI1 [29], in the progression of ovarian cancer cells. We have been focusing our studies on the role of METCAM/MUC18 in the progression of several epithelial tumors, including epithelial ovarian tumors [30].…”
Section: Cell Adhesion Molecules and The Progression Of Ovarian Cancermentioning
confidence: 99%
“…10,15 Although an appropriate mAb to assess CD47 protein expression in formalin-fixed paraffin-embedded (FFPE) human samples does not currently exist, several recent studies performed immunohistochemical (IHC) analyses on human tumor samples using polyclonal antibodies against CD47. 16,17 In addition to the expression of CD47 by cancer cells, the roles of M2 in TME have been comprehensively investigated; however, the relationship between the expression of CD47 in cancer tissues and macrophage subsets in the peritumoral area remains unclear. Zhang et al 18 previously reported migratory, but not phagocytic activity in relation to the expression of CD47 and the M1/M2 context with a series of CD47 IHC analyses on patients with malignancies; however, differences in the potential and mechanisms underlying phagocytosis by M1 and M2 in relation to the expression of CD47 or dynamisms among macrophage subsets in TME have not yet been elucidated in detail.…”
mentioning
confidence: 99%