Expression and Significance of ER, PR, VEGF, CA15-3, CA125 and CEA in Judging the Prognosis of Breast Cancer

Abstract

Objective: To explore the expression and significance of estrogen receptor (ER), progestrone receptor (PR), vascular endothelial growth factor (VEGF), CA15-3, CA125 and carcinoma embryonic antigen (CEA) expression in judging the prognosis of breast cancer. Materials and Methods: Sixty-five patients with breast cancer undergoing operations in the general surgery department were considered as the observation group, and 50 healthy outpatients of our hospital as the control group. Cubital venous blood was drawn in the morning from fasting patients in the two groups and chemiluminescence immunoassays were used to detect the levels of CA15-3, CA125 and CEA in serum. The follow-up duration was from 4 months to 2 years, and change in levels of the indicators was detected by dynamically drawing blood. After surgery, cancer tissue samples of patients in observation group remained on file (the non-recurrent patients were biopsied). Immunohistochemistry was applied to determine the expression of ER, PR and VEGF in tissue. Results: The effective rate of 12 patients with negative ER and PR expression was 33.3% in the observation group, being associated with prognosis to varying extents. Serum CA15-3, CA125 and CEA in the observation group were all significantly higher than in control group (p<0.01). With increase in pathological staging, levels of serum CA15-3, CA125 and CEA gradually increased (p<0.01). Levels in patients with lymph node metastasis were markedly higher than in those without (p<0.01). In addition, values with distal lymph node metastasis were notably higher than with adjacent lymph node metastasis (p<0.01). The postoperative follow-up results revealed that positive VEGF and levels of serum VEGF, CA15-3, CA125 and CEA in recurrence group were obviously higher than in non-recurrence group (p<0.01). Conclusions: Joint detection of ER and PR expression as well as levels of serum VEGF, CA15-3, CA125 and CEA is meaningful and can guide the diagnosis and treatment for breast cancer.

Significant Correlation between Salivary and Serum Ca 15-3 in Healthy Women and Breast Cancer Patients

“…The expression of CA15-3 increases significantly in most breast carcinomas (Frenette et al, 1994;Toth et al, 2008;Moazzezy et al, 2014). It was also shown that the rate of CA15-3 is correlated with tumor size, which reflects the stage of the disease (Clinton et al, 2003;Nicolini et al, 2008;Atoum et al, 2012;Zhang et al, 2013).…”

Serum Vascular Endothelial Growth Factor-A (VEGF-A) as a Biomarker in Squamous Cell Carcinoma of Head and Neck Patients Undergoing Chemoradiotherapy

“…VEGF is a multifunctional cytokine that exerts a variety of effects on vascular endothelial cells that together promote the formation of new blood vessels, increases vascular endothelial permeability, stimulates the proliferation of endothelial cells and promote cancer cell progression (Dvorak, 2002;Mohammed et al, 2007;Niu et al, 2010;Akdeniz et al, 2013;Huang et al, 2013;Zhang et al, 2013). In particular, serum VEGF-A levels are elevated in patients with HNSCC compared to healthy controls (De Schutter et al, 2005;Hong et al, 2009;Liang et al, 2013).…”

Differentially Expressed Proteins in ER+MCF7 and ER-MDA-MB-231 Human Breast Cancer Cells by RhoGDI-α Silencing and Overexpression

“…It is well established that ER expression is linked to prognosis (Sofi et al, 2012;Zhang et al, 2013). Previous studies reported the proteomic profiles of ER + MCF7 and ER -MDA-MB-231 breast cancer cells.…”