Expression and significance of TLR4 and HIF-1α in pancreatic ductal adenocarcinoma

Zhang, Jianjun; Wu, Heshui; Wang, Lin; Tian, Yuan; Zhang, Jinghui; Wu, Hailong

doi:10.3748/wjg.v16.i23.2881

Cited by 87 publications

(106 citation statements)

References 31 publications

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“…In solid tumors, hypoxia is a common phenomenon, and it is associated with poor prognosis regardless of therapy strategy (Birner et al, 2000;Bachtiary et al, 2003), suggesting that it might be an important therapeutic target. DOI:http://dx.doi.org/10.7314/APJCP.2013.14.6.3613 Hypoxia Inducible Factor-1α and Lysyl Oxidase in Non-small Cell Lung Cancer As previously published, HIF-1α is overexpressed in many human malignancies and their metastases, compared with their paired normal tissues (Zhong et al, 1999;Zhang et al, 2010). However, association of HIF-1α with clinicopathological characteristics and prognosis is inconsistent.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Expression and Significance of Hypoxia Inducible Factor-1α and Lysyl Oxidase in Non-small Cell Lung Cancer

Wei

Jiang²,

Chen³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 98%

“…Specimens scored differently by the two investigators were reevaluated and then classified according to the best assessment of the observers. The criteria of evaluation were determined as described by previous reports (Albinger-Hegyi et al, 2010;Zhang et al, 2010).…”

Section: Immunohistochemistrymentioning

confidence: 99%

Expression and Significance of Hypoxia Inducible Factor-1α and Lysyl Oxidase in Non-small Cell Lung Cancer

Wei

Jiang²,

Chen³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Breast and prostate carcinomas (Gonzalez-Reyes et al, 2010;Gonzalez-Reyes et al, 2011) TLR3, 4, 7, and 9 Esophageal squamous cell carcinoma (Sheyhidin et al, 2011) TLR4 Colon carcinoma, human head and neck squamous cell carcinoma, melanoma cell lines, NB-1 neuroblastoma, lung carcinoma, pancreatic ductal adenocarcinoma, colorectal carcinoma, adrenocortical carcinoma, ovarian cancer cell lines, bladder cancer cells (Hassan et al, 2006;Molteni et al, 2006;Doan et al, 2009;Qian et al, 2009;Szajnik et al, 2009;Szczepanski et al, 2009;Kanczkowski et al, 2010;Tang et al, 2010;Zhang et al, 2010;Xu et al, 2011) TLR4 and 9 Lung carcinoma (Zhang et al, 2009b) TLR4, 5, and 9 Gastric carcinoma (Schmausser et al, 2005) TLR5 Cervical tumor cells, breast cancer cells, colon carcinoma, gastric cancer cells (Kim et al, 2008;Rhee et al, 2008;Cai et al, 2011;Song et al, 2011) TLR7 (Huang et al, 2005;Yang et al, 2010) of several human cancers, including neuroblastoma, breast adenocarcinoma, and cervical, hepatocellular, papillary thyroid, nasopharyngeal and lung carcinomas. TLR4 expression in human lung cancer cells was demonstrated (He et al, 2007b).…”

Section: Tlr3mentioning

confidence: 99%

Roles of toll-like receptors in Cancer: A double-edged sword for defense and offense

et al. 2012

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Toll-like receptors (TLRs) belong to a class of pattern-recognition receptors that play an important role in host defense against pathogens by recognizing a wide variety of pathogen-associated molecular patterns (PAMPs). Besides driving inflammatory responses, TLRs also regulate cell proliferation and survival by expanding useful immune cells and integrating inflammatory responses and tissue repair processes. TLR signaling, which is centrally involved in the initiation of both innate and adaptive immune responses, has been thought to be restricted to immune cells. However, recent studies have shown that functional TLRs are expressed not only on immune cells, but also on cancer cells, thus implicating a role of TLRs in tumor biology. Increasing bodies of evidence have suggested that TLRs act as a double-edged sword in cancer cells because uncontrolled TLR signaling provides a microenvironment that is necessary for tumor cells to proliferate and evade the immune response. Alternatively, TLRs can induce an antitumor immune response in order to inhibit tumor progression. In this review, we summarize the dual roles of TLRs in tumor cells and, more importantly, delve into the therapeutic potential of TLRs in the context of tumorigenesis.

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“…In ovarian tumors, high HIF-1α expression was correlated with grade of the tumors. However, in pancreatic ductal adenocarcinoma, no association was observed between grade and HIF-1α expression (20,23). Although endometrium cancer is the most common female genital tract cancer, the majority are diagnosed at an early stage and they are associated with a favorable prognosis.…”

Section: Discussionmentioning

confidence: 99%

The investigation of tumoral angiogenesis with HIF-1 alpha and microvessel density in women with endometrium cancer

Aybatli¹,

Sayın²,

Kaplan³

et al. 2012

J Turkish German Gynecol Assoc

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Objective: Hypoxia inducible factor 1 alpha (HIF-1α) is a nuclear protein upregulated in response to reduced cellular oxygen concentration which therefore acts as a marker for hypoxia. The aim of this study was to determine tumoral angiogenesis with immunohistochemical markers in endometrium cancer and its relation with stage, grade, survival rates and other prognostic factors. Material and Methods:Using the database in our Gynecologic Oncology clinic, we selected 94 patients who were diagnosed with endometrial cancer and underwent primary surgery at our institution between 2001 and 2010. Tissue microarrays believed to demonstrate the optimum part of the tumor were reprepared from the paraffin blocks. Angiogenesis and microvessel density (MVD) were investigated with the aid of HIF-1α and CD34 antibodies.Results: High expression of HIF-1α was significantly more frequent in advanced grade endometrial cancers (p=0.044). HIF-1α expression was highly correlated with CD34 expression in the tumor cells (p<0.001). However lack of relation among stage, overall survival rates and histological types were analyzed with HIF-1α. When we compared HIF-1α positive and negative cases with cervical, adnexial, lymphovascular and myometrial invasion, there was no difference between these groups. MVD was evaluated with CD34 and it was remarkable and significantly different on advanced grade tumors (r=0.268; p=0.009). A similar significant difference was observed between the high expression of CD34 and type II endometrial cancer histology (p<0.001). However, there was no relationship between the MVD and stage or survival rates. Conclusion:High expression of HIF-1α is associated with tumoral angiogenesis in endometrial adenocarcinomas. Further studies targeting HIF-1α for disrupting mechanisms essential for tumor growth in endometrium cancer will be significant investigations in the future. (J Turkish-German Gynecol Assoc 2012; 13: 37-44) Key words: Endometrium cancer, HIF-1α, hypoxia, angiogenesis Received: 21 April, 2011 Accepted: 3 December, 2011 Amaç: Hipoksi ile indüklenen faktör-1α (HIF-1 α) bir nükleer proteindir ve azalan hücre içi oksijen konsantrasyonuna cevap olarak regüle edilir. Bu nedenle bir hipoksi belirteci gibi görev yapar. Bu çalışmanın amacı endometrium kanserli olgularda tümör anjiogenezini immunohistokimyasal belirteçler ile incelemek ve evre, derece ve sağkalım gibi prognostik faktörlerle olan bağlantısını aydınlatmaya çalışmaktır.

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Expression and significance of TLR4 and HIF-1α in pancreatic ductal adenocarcinoma

Abstract: TLR4, NF-kappaB p65 and HIF-1alpha are overexpressed in pancreatic adenocarcinoma, TLR4 may be partly involved in up-regulating HIF-1alpha, and both synergestically promote development of pancreatic adenocarcinoma.

Cited by 87 publications

References 31 publications

Expression and Significance of Hypoxia Inducible Factor-1α and Lysyl Oxidase in Non-small Cell Lung Cancer

Expression and Significance of Hypoxia Inducible Factor-1α and Lysyl Oxidase in Non-small Cell Lung Cancer

Roles of toll-like receptors in Cancer: A double-edged sword for defense and offense

The investigation of tumoral angiogenesis with HIF-1 alpha and microvessel density in women with endometrium cancer

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