Expression and Significance of TWSG1 in Craniofacial Fibrous Dysplasia

Abstract

Objective: This study aims to determine the expression and significance of Triple Wide Straight Grooves 1 (TWSG1) in craniofacial fibrous dysplasia (FD). Methods: TWSG1 expression was examined in specimens obtained from 44 patients with FD by immunohistochemistry. Results: TWSG1 expression was positive in all FD patients, which was higher than in patients with normal mandible in the negative control group (P<0.05). Furthermore, the positive rate of TWSG1 was slightly higher than in adult patients with FD (P<0.05), which was classified by post-operativerecurrence or no recurrence. Moreover, the positive expression of TWSG1 in FD with favorable prognosis was higher than that with poor prognosis (P<0.05). Conclusion: The overexpression of TWSG1 is a vital biological marker in the prognosis of FD.