Expression and Transport Characteristics of Urea Channel Protein B in Rat Bladder Cance

Abstract

The complex process of multiple genes and steps in the development of bladder tumor is definitely related to the abnormal expression of multiple tumor suppressor genes. The purpose of this study is to investigate the expression and transport characteristics of urea channel protein B in rat bladder cancer. In this study, the expression of urea channel protein B in 70 cases of bladder cancer and 30 cases of normal bladder tissue was determined by immunohistochemistry. The results of immunohistochemistry were analyzed with the sex, size, number, pathological grade and clinical stage of bladder cancer. The results showed that the expression rate of UT-B was 72.86% (51 / 70) in bladder cancer tissue and 26.67% (8 / 30) in normal bladder tissue, the difference was statistically significant (P < 0.05). The positive rate of UT-B was 54.17% (13/24) in low-grade bladder cancer and 82.61% (38/46) in high-grade bladder cancer, the difference was statistically significant (P<0.05). The positive expression rate of UT-B was 61.11% (22/36) in non-muscle invasive bladder cancer and 85.29% (29/34) in muscle invasive bladder cancer, the difference was statistically significant (P< 0.05). There was no significant difference in the expression rate of UT-B between the groups of gender, age, tumor size and tumor number (P > 0.05).