Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups

Seidler, Heinrich; Utsuyama, Masanori; Nagaoka, Sakae; Takemura, Tamiko; Kitagawa, Masanobu; Hirokawa, Katsuíku

doi:10.1016/j.yexmp.2003.12.004

Cited by 17 publications

(7 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In MEC, ␤-catenin labeling was observed in the membrane, cytoplasm, and nucleus. In general, there was a predominance of labeling in the cytoplasm compared with the cell membrane, a fact also observed by Seidler et al 17 for colorectal adenocarcinomas. Several investigators have reported nuclear or cytoplasmic detection of ␤-catenin, and this redistribution has been associated with its transactivation potential mediated by the Wnt signaling pathway.…”

Section: Commentsupporting

confidence: 77%

β-Catenin and Cyclin D1 in Mucoepidermoid Carcinoma of Variable Histologic Grades

Miguel

Oliveira²,

Seabra³

et al. 2005

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

Section: Commentsupporting

confidence: 77%

β-Catenin and Cyclin D1 in Mucoepidermoid Carcinoma of Variable Histologic Grades

Miguel

Oliveira²,

Seabra³

et al. 2005

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…It functions as a transcription factor that regulates transcription of specific target genes. Some findings indicate that failure of the normal apoptotic process together with de-regulation of c-MYC proto-oncogene might promote the development of colorectal tumors and its overexpression is observed in most colorectal cancers 63, 64.…”

Section: Resultsmentioning

confidence: 99%

Biological and functional analysis of statistically significant pathways deregulated in colon cancer by using gene expression profiles

Distaso¹,

Abatangelo²,

Maglietta³

et al. 2008

Int. J. Biol. Sci.

View full text Add to dashboard Cite

Gene expression profiling offers a great opportunity for studying multi-factor diseases and for understanding the key role of genes in mechanisms which drive a normal cell to a cancer state. Single gene analysis is insufficient to describe the complex perturbations responsible for cancer onset, progression and invasion. A deeper understanding of the mechanisms of tumorigenesis can be reached focusing on deregulation of gene sets or pathways rather than on individual genes. We apply two known and statistically well founded methods for finding pathways and biological processes deregulated in pathological conditions by analyzing gene expression profiles. In particular, we measure the amount of deregulation and assess the statistical significance of predefined pathways belonging to a curated collection (Molecular Signature Database) in a colon cancer data set. We find that pathways strongly involved in different tumors are strictly connected with colon cancer. Moreover, our experimental results show that the study of complex diseases through pathway analysis is able to highlight genes weakly connected to the phenotype which may be difficult to detect by using classical univariate statistics. Our study shows the importance of using gene sets rather than single genes for understanding the main biological processes and pathways involved in colorectal cancer. Our analysis evidences that many of the genes involved in these pathways are strongly associated to colorectal tumorigenesis. In this new perspective, the focus shifts from finding differentially expressed genes to identifying biological processes, cellular functions and pathways perturbed in the phenotypic conditions by analyzing genes co-expressed in a given pathway as a whole, taking into account the possible interactions among them and, more importantly, the correlation of their expression with the phenotypical conditions.

show abstract

“…The role of cell-cell contact in Hippo pathway regulation should be further investigated in the context of chronological age. Both Wnt/beta-catenin and NF2 also are known to regulate YAP/TAZ in vivo(Cockburn et al, 2013; Imajo et al, 2012), and changes to both pathways have been implicated in different age-related cancers(Evans et al, 2005; Seidler et al, 2004). Little is known about whether YAP/TAZ play a role in other phenotypes of aging.…”

Section: Discussionmentioning

confidence: 99%

Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors

et al. 2014

View full text Add to dashboard Cite

Summary Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelia aging for reasons not understood. Multipotent progenitors from women aged <30 years were exposed to a physiologically relevant range of matrix elastic modulus, and increased rigidity caused a differentiation bias towards myoepithelial cells while reducing production of luminal cells and progenitor maintenance. Lineage representation in progenitors from women >55 years was unaffected by physiological modulus changes. Efficient activation of Hippo pathway transducers YAP and TAZ was required for the modulus-dependent myoepithelial/basal-bias in younger progenitors. In older progenitors YAP/TAZ were only activated when stressed by extra-physiologically rigid matrices, which biased differentiation towards luminal-like phenotypes. YAP was primarily active in myoepithelia of younger breast tissues, but activity increased in luminal cells with age. Thus aging phenotypes of mammary epithelia may arise partly because alterations in Hippo pathway activation affect the processes of progenitor differentiation and lineage specificity.

show abstract

Expression level of Wnt signaling components possibly influences the biological behavior of colorectal cancer in different age groups

Cited by 17 publications

References 38 publications

β-Catenin and Cyclin D1 in Mucoepidermoid Carcinoma of Variable Histologic Grades

β-Catenin and Cyclin D1 in Mucoepidermoid Carcinoma of Variable Histologic Grades

Biological and functional analysis of statistically significant pathways deregulated in colon cancer by using gene expression profiles

Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors

Contact Info

Product

Resources

About