Expression levels of endogenous hydrogen sulfide are altered in patients with allergic rhinitis

Park, Se Jin; Kim, Tae Hoon; Lee, Jun Young; Ryu, Hyei Yul; Hong, Ki Hong Waun Ki; Jung, Jaebong; Hwang, Gyu Ho; Lee, Sang Hag

doi:10.1002/lary.23466

Cited by 13 publications

(13 citation statements)

References 25 publications

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“…In a guinea pig model of ovalbumin-induced allergic rhinitis, the levels of serum H 2 S and CSE mRNA expression in nasal mucosa were significantly reduced and the clinical disease was more severe upon administration of the CSE inhibitor PAG (44,45). However, two human studies of nasal mucosal samples isolated from patients with allergic rhinitis showed higher levels of H 2 S, CSE, and CBS mRNA and protein expression (46), and no correlation with either the severity of disease or the presence or absence of polyps (47).…”

Section: Allergic Rhinitismentioning

confidence: 97%

Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses

Bazhanov¹,

Ansar

Ivanciuc³

et al. 2017

Am J Respir Cell Mol Biol

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Hydrogen sulfide (HS) is a biologically relevant signaling molecule in mammals. Along with the volatile substances nitric oxide (NO) and carbon monoxide (CO), HS is defined as a gasotransmitter. It plays a physiological role in a variety of functions, including synaptic transmission, vascular tone, angiogenesis, inflammation, and cellular signaling. The generation of HS is catalyzed by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase (3-MST). The expression of CBS and CSE is tissue specific, with CBS being expressed predominantly in the brain, and CSE in peripheral tissues, including lungs. CSE expression and activity are developmentally regulated, and recent studies suggest that CSE plays an important role in lung alveolarization during fetal development. In the respiratory tract, endogenous HS has been shown to participate in the regulation of important functions such as airway tone, pulmonary circulation, cell proliferation or apoptosis, fibrosis, oxidative stress, and inflammation. In the past few years, changes in the generation of HS have been linked to the pathogenesis of a variety of acute and chronic inflammatory lung diseases, including asthma and chronic obstructive pulmonary disease. Recently, our laboratory made the critical discovery that cellular HS exerts broad-spectrum antiviral activity both in vitro and in vivo, in addition to independent antiinflammatory activity. These findings have important implications for the development of novel therapeutic strategies for viral respiratory infections, as well as other inflammatory lung diseases, especially in light of recent significant efforts to generate controlled-release HS donors for clinical therapeutic applications.

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Section: Allergic Rhinitismentioning

confidence: 97%

Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses

Bazhanov¹,

Ansar

Ivanciuc³

et al. 2017

Am J Respir Cell Mol Biol

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“…A previous study in humans has suggested that this gasotransmitter may have multiple functions in human nasal mucosa and contribute to the development of allergic symptoms such as rhinorrhea, sneezing and nasal stuffiness. 234 However, other studies on the regulation of the endogenous H2S pathway in the nasal mucosa of an AR guinea pig model has suggested that H2S may exert anti-inflammatory as well as antioxidant effects in the nasal mucosa and therefore may serve a protective function in AR patients. 235 …”

Section: Mechanismsmentioning

confidence: 99%

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Cheng

Chen

et al. 2018

Allergy Asthma Immunol Res

260

198

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Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2–3 decades in developing countries including China, with the prevalence of AR varying widely in these countries. A survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. An increasing number of original articles and imporclinical trials on the epidemiology, pathophysiologic mechanisms, diagnosis, management and comorbidities of AR in Chinese subjects have been published in international peer-reviewed journals over the past 2 decades, and substantially added to our understanding of this disease as a global problem. Although guidelines for the diagnosis and treatment of AR in Chinese subjects have also been published, they have not been translated into English and therefore not generally accessible for reference to non-Chinese speaking international medical communities. Moreover, methods for the diagnosis and treatment of AR in China have not been standardized entirely and some patients are still treated according to regional preferences. Thus, the present guidelines have been developed by the Chinese Society of Allergy to be accessible to both national and international medical communities involved in the management of AR patients. These guidelines have been prepared in line with existing international guidelines to provide evidence-based recommendations for the diagnosis and management of AR in China.

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“…These results are in accordance with those of our previous results evaluated in human nasal mucosa. 32 These observations imply that in human nasal and sinus mucosa, CBS may be the main H 2 S-producing enzyme in superficial and submucosal glandular epithelium, and CSE may Copyright (c) Oceanside Publications, Inc. All rights reserved. For permission to copy go to https://www.oceansidepubl.com/permission.htm CRS.…”

Section: Discussionmentioning

confidence: 95%

Endogenous Production of Hydrogen Sulfide in Human Sinus Mucosa and its Expression Levels are Altered in Patients with Chronic Rhinosinusitis with and without Nasal Polyps

Hwang

Jun

Park

et al. 2014

Am J Rhinol�Allergy

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Expression levels of endogenous hydrogen sulfide are altered in patients with allergic rhinitis

Cited by 13 publications

References 25 publications

Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses

Hydrogen Sulfide: A Novel Player in Airway Development, Pathophysiology of Respiratory Diseases, and Antiviral Defenses

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Endogenous Production of Hydrogen Sulfide in Human Sinus Mucosa and its Expression Levels are Altered in Patients with Chronic Rhinosinusitis with and without Nasal Polyps

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