1997
DOI: 10.1006/bbrc.1997.6865
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Expression, Nuclear Localization and Interactions of Human MCM/P1 Proteins

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Cited by 53 publications
(39 citation statements)
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“…The Mcm proteins are rather abundant proteins even in serum-starved resting ®broblasts (Tsuruga et al, 1997a). Thus, expression of the MCM genes may not be rate limiting for serum-starved ®broblasts to initiate DNA replication after stimulation with serum.…”
Section: Discussionmentioning
confidence: 99%
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“…The Mcm proteins are rather abundant proteins even in serum-starved resting ®broblasts (Tsuruga et al, 1997a). Thus, expression of the MCM genes may not be rate limiting for serum-starved ®broblasts to initiate DNA replication after stimulation with serum.…”
Section: Discussionmentioning
confidence: 99%
“…By using RNA probes spanning sequences upstream of HsMCM5 and HsMCM6 cDNAs, fragments with multiple sizes were protected with mRNAs from human T cell lines MT-2 and Kit 225 (Figure 2A), indicating multiple transcriptional start sites around which no typical splicing acceptor consensus sequences were found. These possible transcriptional start sites of the HsMCM5 gene clustered about 15 bp upstream of the 5' end of HsMCM5 cDNA (Tsuruga et al, 1997a). There are two sets of putative E2F binding elements arranged in an overlapping fashion in the 5'¯anking sequence of HsMCM5 cDNA.…”
Section: Hsmcm5 and Hsmcm6 Promotersmentioning
confidence: 99%
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“…Six mammalian homologs of the MCM family members (MCM2 through MCM7) have been identified (reviewed in 130), all being dramatically induced by growth stimulation of serum-starved human fibroblast KD cells and rat fibroblast REF52 cells, with peaks at the G1/S boundary (91,131). Cell cycle-dependent fluctuation has been demonstrated at the mRNA level with MCM2, 4, 5 and 6, and at the protein level with Mcm6 in human epithelial HeLa and REF52 cells (91,132).…”
Section: Regulatory Machinery For Dna Replicationmentioning
confidence: 99%
“…Cell cycle-dependent fluctuation has been demonstrated at the mRNA level with MCM2, 4, 5 and 6, and at the protein level with Mcm6 in human epithelial HeLa and REF52 cells (91,132). Human MCM5, MCM6 and MCM7, and murine MCM3 have been shown to contain E2F sites in their promoters, and at least for human MCM5 and MCM6 these E2F sites are primarily responsible for the cell cycleregulated expression (67,(131)(132)(133)(134). Considering the fact that overexpression of E2F causes induction of all endogenous MCM family mRNAs in REF52 cells (67,91), it is likely that there is a common regulation by E2F.…”
Section: Regulatory Machinery For Dna Replicationmentioning
confidence: 99%