Expression of A, B, and H Blood Group Antigens in Epithelial Ovarian Cancer: Relationship to Tumor Grade and Patient Survival

Welshinger, Marie; Finstad, Connie L.; Venkatraman, Ennapadam; Federici, Mark G.; Rubin, Stephen C.; Lewis, John L.; Lloyd, Kenneth O.

doi:10.1006/gyno.1996.0198

Cited by 26 publications

(29 citation statements)

References 2 publications

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“…It is likely, however, that these technical considerations are not solely responsible for the observed dierences, but that there are some critical basic dierences between the histogenesis of colorectal cancer and other carcinomas. One such dierence is in the expression or absence of blood group antigens in the normal epithelium from which the tumor derives (Welshinger et al 1996). The normal epithelium in many, but not all, organs expresses ABH isoantigens, whereas the erythrocyte as well as the vascular endothelium is universally positive for these antigens, as determined by immunological methods (Coon and Weinstein 1986).…”

Section: Discussionmentioning

confidence: 99%

“…This result was also obtained in previous studies (Yuan et al 1985). In this way, normal colorectal epithelium resembles the epithelial cells of the ovary and mesothelial cells of the testis and the central nervous system, which do not express blood group antigens (Welshinger et al 1996;Coon and Weinstein 1986). Approximately half of the colorectal or ovarian carcinomas derived from these tissues that normally do not synthesize ABH isoantigens express the appropriate isoforms of these antigens.…”

Section: Discussionmentioning

confidence: 99%

“…Approximately half of the colorectal or ovarian carcinomas derived from these tissues that normally do not synthesize ABH isoantigens express the appropriate isoforms of these antigens. In addition, Welshinger et al reported that the presence or absence of ABH isoantigen expression does not correlate with survival in ovarian cancer patients (Welshinger et al 1996). Lee et al also reported that ABH isoantigen status bears no signi®cant relationship to clinical and pathological parameters and does not serve as a useful prognostic factor in breast cancer patients (Lee et al 1985).…”

Section: Discussionmentioning

confidence: 99%

“…The A and B alleles of the ABO locus code for speci®c glycosyltransferases, which then modify the oligosaccharide that is the product of the glycosyltransferase of a second gene, H (Watkins 1974;Dresler et al 1995). A likely mechanism for the alteration of ABH isoantigen expression in colorectal tissue is the loss or reduction of the glycosyltransferase enzymes required for the synthesis of ABH determinants (Welshinger et al 1996). The availability of the macromolecules that carry the blood group structures, such as mucin or glycolipids, may also in¯uence ABH antigen expression.…”

Section: Discussionmentioning

confidence: 99%

“…The availability of the macromolecules that carry the blood group structures, such as mucin or glycolipids, may also in¯uence ABH antigen expression. Alternatively, other carbohydrate structures, not recognized by the antibody reagents used in this study, may be expressed in some colorectal carcinomas showing absence of ABH isoantigens (Welshinger et al 1996). Further investigation is needed to elucidate the possible molecular and genetic basis involved in generating these alterations.…”

Section: Discussionmentioning

confidence: 99%

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Expression of blood group antigens A, B and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients

Nakagoe

Nanashima

Sawai

et al. 2000

J Cancer Res Clin Oncol

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The deletion of blood group ABH isoantigens on tumor tissues has been reported to be an adverse prognostic marker for patients with various solid tumors. In the present study, we evaluated the prognostic value of altered expression of ABH isoantigens in colorectal carcinomas. Using monoclonal antibodies, the expression of A, B, and H antigens was assessed by immunohistochemistry on paraffin-embedded carcinoma samples from 82 patients who had undergone surgery for colorectal cancer. ABH isoantigens were found to be deleted in 36 carcinomas (43.9%) and expressed in 46 (56.1%). Univariate and multivariate analysis using a logistic regression model revealed that N factor (lymph node metastasis) and blood group type were independently related to the expression of ABH isoantigens. In contrast to previous reports on other cancers, patients whose colorectal carcinomas express ABH isoantigens had a poorer prognosis than those whose carcinomas showed deletion of ABH isoantigens (P = 0.0008). The expression of ABH isoantigens was an independent prognostic variable, in addition to T (depth of tumor invasion), N, and M (distant metastasis) factors, as shown by means of Cox regression analysis. In conclusion, the expression of ABH isoantigens in carcinoma tissue is an important poor prognostic factor in patients with colorectal cancer. This variable needs to be considered in the design of future trials of therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Expression of blood group antigens A, B and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients

Nakagoe

Nanashima

Sawai

et al. 2000

J Cancer Res Clin Oncol

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Selection of carbohydrate antigens in human epithelial ovarian cancers as targets for immunotherapy: Serous and mucinous tumors exhibit distinctive patterns of expression

et al. 1999

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Expression of blood group–related carbohydrate antigens was examined in frozen sections from a series of ovarian carcinomas of different histological types using an indirect immunoperoxidase technique. Antigenic specificities belonging to the O(H) and Lewis blood group families (H‐1, H‐2, Lea, sLea, Lex, sLex, Leb and Ley) or the mucin‐core family (Tn, sTn and TF) were studied. A distinct difference in antigen expression between mucinous and other ovarian carcinomas (serous and endometrioid) was observed. Specifically, mucinous tumors tended to express sTn, Lea and sLea strongly and homogeneously, whereas serous and endometrioid tumors rarely expressed these specificities and, in contrast, expressed Ley and H type 2 antigen strongly. When expressed in serous tumors, sTn was usually distributed in a heterogeneous pattern, whereas sTn expression in mucinous tumors was much more homogeneous. The distribution of Ley in serous tumors was noticeably homogeneous. H‐1, Lex, sLex,, Leb , TF and Tn specificities were rarely expressed in any type of ovarian carcinoma. Our results provide further support for the different histogenesis of mucinous and non‐mucinous tumors and indicate alternative differentiation pathways for the 3 pathological subtypes of ovarian tumor. They also provide the basis for the choice of carbohydrate antigens for active and passive immunotherapy of ovarian carcinomas. Int. J. Cancer 81:193–198, 1999. © 1999 Wiley‐Liss, Inc.

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Selection of carbohydrate antigens in human epithelial ovarian cancers as targets for immunotherapy: Serous and mucinous tumors exhibit distinctive patterns of expression

Federici¹,

Kudryashov²,

Saigo³

et al. 1999

Int. J. Cancer

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Expression of blood group-related carbohydrate antigens was examined in frozen sections from a series of ovarian carcinomas of different histological types using an indirect immunoperoxidase technique. Antigenic specificities belonging to the O(H) and Lewis blood group families (H-1, H-2, Le a , sLe a , Le x , sLe x , Le b and Le y ) or the mucin-core family (Tn, sTn and TF) were studied. A distinct difference in antigen expression between mucinous and other ovarian carcinomas (serous and endometrioid) was observed. Specifically, mucinous tumors tended to express sTn, Le a and sLe a strongly and homogeneously, whereas serous and endometrioid tumors rarely expressed these specificities and, in contrast, expressed Le y and H type 2 antigen strongly. When expressed in serous tumors, sTn was usually distributed in a heterogeneous pattern, whereas sTn expression in mucinous tumors was much more homogeneous. The distribution of Le y in serous tumors was noticeably homogeneous. H-1, Le x , sLe x, , Le b , TF and Tn specificities were rarely expressed in any type of ovarian carcinoma. Our results provide further support for the different histogenesis of mucinous and non-mucinous tumors and indicate alternative differentiation pathways for the 3 pathological subtypes of ovarian tumor. They also provide the basis for the choice of carbohydrate antigens for active and passive immunotherapy of ovarian carcinomas. Int.

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Expression of A, B, and H Blood Group Antigens in Epithelial Ovarian Cancer: Relationship to Tumor Grade and Patient Survival

Cited by 26 publications

References 2 publications

Expression of blood group antigens A, B and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients

Expression of blood group antigens A, B and H in carcinoma tissue correlates with a poor prognosis for colorectal cancer patients

Selection of carbohydrate antigens in human epithelial ovarian cancers as targets for immunotherapy: Serous and mucinous tumors exhibit distinctive patterns of expression

Selection of carbohydrate antigens in human epithelial ovarian cancers as targets for immunotherapy: Serous and mucinous tumors exhibit distinctive patterns of expression

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