1996
DOI: 10.1016/s0190-9622(96)90005-5
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Expression of a glycoprotein of the carcinoembryonic antigen family in normal and neoplastic sebaceous glands

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Cited by 32 publications
(16 citation statements)
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“…Moreover, although LNs from patients with benign disease were negative for MUC1, 3 out of 4 PBMNs from healthy volunteers gave positive results demonstrating a crossreaction with noncarcinomatous cells. These results, already reported by others, 24,25 could be due to expression of MUC1 mRNA by skin sebaceous and sweat glands contaminating blood samples collected by transcutaneous venipuncture 34 or by monocytes. 35 Therefore, MUC1 mRNA detection was not considered to be a reliable marker for the detection of micrometastatic cells.…”
Section: Discussionsupporting
confidence: 66%
“…Moreover, although LNs from patients with benign disease were negative for MUC1, 3 out of 4 PBMNs from healthy volunteers gave positive results demonstrating a crossreaction with noncarcinomatous cells. These results, already reported by others, 24,25 could be due to expression of MUC1 mRNA by skin sebaceous and sweat glands contaminating blood samples collected by transcutaneous venipuncture 34 or by monocytes. 35 Therefore, MUC1 mRNA detection was not considered to be a reliable marker for the detection of micrometastatic cells.…”
Section: Discussionsupporting
confidence: 66%
“…The only normal tissue with membranous staining was the sebaceous gland; the expression of membranous MUC1 is described to be restricted to mature sebocytes. 19 The antibody binds specifically and preferentially to differentially glycosylated MUC1 in immunohistochemistry. Thus, although the epitope of the PH1 antibody may fall outside the amino acids that are putatively glycosylated, its binding may still be affected because of steric hindrance or carbohydrate-induced conformational changes of the epitope within the tandem repeat region, as described by Spencer and colleagues 28 for the antibody C595 that binds to the RPAP epitope.…”
Section: Discussionmentioning
confidence: 99%
“…The only normal tissue with membranous staining is the sebaceous gland; the expression of membranous MUC1 is described to be restricted to mature sebocytes. 19 Taken together, a differential expression between normal tissue and tumor was found in bladder, lung, breast, ovary, pancreas, parathyroid, and prostate. Apical stain- ing was detected in normal tissues; depolarized cellular staining is most frequently observed in tumors and aberrant staining of the whole-cell membrane is only demonstrated in tumors with the exception of the sebaceous glands of the skin.…”
Section: Immunohistochemical Analysis Of Ph1-igg1mentioning
confidence: 96%
“…A study comparing the expression of glycoprotein antigens of the carcinoembryonic antigen (CEA) family in normal sebaceous glands and cutaneous neoplasms with a sebaceous differentiation found that both sebaceous and sweat glands expressed EMA, although the expression of the CEA antigens was more restricted. [108] At the ultrastructural level, EMA was demonstrated in the Golgi complex, in small vesicles and on the cell membrane. Further, the expression of EMA was conserved even in reactive, hamartomatous and neoplastic proliferations of adnexal structures with a sebaceous differentiation pattern.…”
Section: Mucin Expression In Malignant Neoplasms Arising In the Skinmentioning
confidence: 99%