Expression of a heparan sulfate remodeling enzyme, heparan sulfate 6-O-endosulfatase sulfatase FP2, in the rat nervous system

Nagamine, Satoshi; Koike, Seiichi; Keino‐Masu, Kazuko; Masu, Masayuki

doi:10.1016/j.devbrainres.2005.07.006

Cited by 38 publications

(44 citation statements)

References 28 publications

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“…Like mouse Sulf1, strong expression is conserved in many structures including the spinal cord, floor plate, choroid plexus, forebrain, midbrain, hindbrain, limb/pectoral fin buds, heart, somites, and blood vessels. In particular, the zebrafish sulf1 expression pattern in the spinal cord is highly similar to that of rodents (Nagamine et al, 2005;Lum et al, 2007;Winterbottom and Pownall, 2009). Like the mammalian Sulf homologs, sulf1 is the major source of Sulf in the eye and olfactory epithelium.…”

Section: Comparison Of Hs Sulf1 Expression From Various Speciesmentioning

confidence: 87%

Dynamic expression patterns of 6‐O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2

Gorsi

Whelan

2010

Developmental Dynamics

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The 6-O-endosulfatase enzymes (Sulfs) edit the final sulfation pattern and function of heparan sulfate (HS) by removal of 6-O-sulfate groups from the chain. To date, two mammalian sulf genes have been identified that regulate many signalling pathways during embryonic development. In zebrafish a sulf1 ortholog and duplicate copies of the mammalian sulf2 gene, sulf2a and sulf2, have been identified, which contain conserved motifs characteristic of vertebrate sulf genes. Zebrafish sulf1 and sulf2a are broadly expressed in the central nervous system (CNS) and non-neuronal tissue including heart, somite boundaries, olfactory system, and otic vesicle, whereas sulf2 expression is almost entirely restricted to the CNS. The duplicate copies of sulf2 have distinct expression patterns, which together mirror that of mouse sulf2, suggesting duplication in the teleost lineage has been followed by subfunctionalisation, whereby both genes need to be preserved by selection to ensure the ancestral gene's expression profile and function is maintained. Developmental Dynamics 239:3312-3323,

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Section: Comparison Of Hs Sulf1 Expression From Various Speciesmentioning

confidence: 87%

Dynamic expression patterns of 6‐O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2

Gorsi

Whelan

2010

Developmental Dynamics

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“…Total RNAs were extracted using Sepasol I (Nacalai Tesque, Kyoto, Japan) and purified using an RNeasy kit (Qiagen, Hilden, Germany). Total RNAs (5 g) were subjected to reverse-transcription using oligo(dT) [12][13][14][15][16][17][18] and Superscript II (Invitrogen). Quantitative PCR was carried out using a LightCycler and LightCycler FastStart DNA Master SYBR Green I reagent (Roche Diagnostics).…”

Section: Methodsmentioning

confidence: 99%

Organ-specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice

Nagamine

Tamba

Ishimine

et al. 2012

Journal of Biological Chemistry

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Background: Extracellular endosulfatases Sulf1 and Sulf2 hydrolyze 6-O-sulfate in heparan sulfate. Results: Disaccharide analysis showed that 2-O-, 6-O-, and N-trisulfated disaccharide units in heparan sulfate were increased to different degrees in different organs in Sulf1 and Sulf2 knock-out mice. Conclusion: Sulfs generate organ-specific sulfation patterns of heparan sulfate. Significance: This may indicate differences in activity between Sulf1 and Sulf2 in vivo.

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“…Structures for vertebrate SULF1 and SULF2 genes and cDNA sequences have been reported, including human (Homo sapiens) [3]; mouse (Mus musculus) [5,22,23]; rat (Rattus norvegicus) [24,25]; frog (Xenopus laevis) [13][14]; and zebra fish (Danio rerio) [16] SULF genes. Human SULF1, which spans 194.3 kilobases and comprises 22 exons, is localized on chromosome 8; whereas human SULF2 spans 128.7 kilobases and comprises 21 exons on chromosome 20 [26,27].…”

Section: Introductionmentioning

confidence: 99%

Comparative and Evolutionary Studies of Vertebrate Extracellular Sulfatase Genes and Proteins: SULF1 and SULF2

Holmes¹

2017

J Proteomics Bioinform

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Expression of a heparan sulfate remodeling enzyme, heparan sulfate 6-O-endosulfatase sulfatase FP2, in the rat nervous system

Cited by 38 publications

References 28 publications

Dynamic expression patterns of 6‐O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2

Dynamic expression patterns of 6‐O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2

Organ-specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice

Comparative and Evolutionary Studies of Vertebrate Extracellular Sulfatase Genes and Proteins: SULF1 and SULF2

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