2002
DOI: 10.1038/sj.leu.2402355
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Expression of a human endogenous retrovirus, HERV-K, in the blood cells of leukemia patients

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Cited by 118 publications
(97 citation statements)
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“…HERV-K transcripts have been found to be expressed in tissue malignancies including melanoma, teratocarcinoma, and prostate cancer as well as hematological malignancies (9)(10)(11)(12). Although more than 50 HERV-Es are estimated to exist in the human genome, this report is, to our knowledge, only the second to identify an HERV-E transcription product expressed in tumor cells (13) and the first to identify an HERV-E expressed in RCC.…”
Section: Figurementioning
confidence: 99%
“…HERV-K transcripts have been found to be expressed in tissue malignancies including melanoma, teratocarcinoma, and prostate cancer as well as hematological malignancies (9)(10)(11)(12). Although more than 50 HERV-Es are estimated to exist in the human genome, this report is, to our knowledge, only the second to identify an HERV-E transcription product expressed in tumor cells (13) and the first to identify an HERV-E expressed in RCC.…”
Section: Figurementioning
confidence: 99%
“…Most of the characterized transposable elements are defective, and include deletions and stop codons in internal regions. Occasionally, insertional mutations of transposable elements cause a genetic disease in human genes (Wilkinson et al, 1990;Lower et al, 1993;Kazazian, 1998;Armbruester et al, 2002) and also contribute to protein variability or versatility (Venables et al, 1995;Halling et al, 1999;Kjellman et al, 1999;Depil et al, 2002). These transposable elements are worth investigating for potential pathogenic effects related to various human cancers.…”
Section: Resultsmentioning
confidence: 99%
“…However, recent studies have revealed that at least some members of the transposable element families are transcriptionally active and may be capable of causing human cancers through several mechanisms. The association of transposable elements with breast cancer (Wang-Johanning et al, 2003b), melanoma (Buscher et al, 2005), seminoma (Rakoff-Nahoum et al, 2006), germ cell tumors (Galli et al, 2005), leukemia (Depil et al, 2002), ovarian carcinomas (Menendez et al, 2004), and prostate adenocarcinoma (Wang-Johanning et al, 2003a) has been suggested. Therefore, transposable elements may play a biological role in cancer development or organismal complexity by introducing transcriptional diversity .…”
Section: Introductionmentioning
confidence: 99%
“…Recent studies of the HERV integration have explored the relationships between human disease and HERVs (Conrad et al, 1994;Depil et al, 2002;Nelson et al, 1999;Wentzensen et al, 2007). For instance, an HERV-K env transcript with protein-coding potential was identified in human breast cancer (Wang-Johanning et al, 2001 and the expression of HERV-K env protein was elevated Edited by Hidenori Nishihara * Corresponding author.…”
Section: Introductionmentioning
confidence: 99%