2014
DOI: 10.3389/fphar.2014.00135
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Expression of ABCG2 (BCRP) in mouse models with enhanced erythropoiesis

Abstract: Haem is a structural component of numerous cellular proteins which contributes significantly to iron metabolic processes in mammals but its toxicity demands that cellular levels must be tightly regulated. Breast Cancer Resistance Protein (BCRP/ABCG2), an ATP Binding Cassette G-member protein has been shown to possess porphyrin/haem efflux function. The current study evaluated the expression and regulation of Abcg2 mRNA and protein levels in mouse tissues involved in erythropoiesis. Abcg2 mRNA expression was en… Show more

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Cited by 7 publications
(5 citation statements)
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“…However, we did not find significant correlations between ENT1 concentrations and NRTI tissue concentrations. Data have been limited to gene expression analyses, which may be altered in the posttranscriptional processes (51,(55)(56)(57). Therefore, with the identification of important drug transporter expression in spleen tissue via QTAP, additional investigations on the location and function of these drug transporters are warranted.…”
Section: Discussionmentioning
confidence: 99%
“…However, we did not find significant correlations between ENT1 concentrations and NRTI tissue concentrations. Data have been limited to gene expression analyses, which may be altered in the posttranscriptional processes (51,(55)(56)(57). Therefore, with the identification of important drug transporter expression in spleen tissue via QTAP, additional investigations on the location and function of these drug transporters are warranted.…”
Section: Discussionmentioning
confidence: 99%
“…For other experiments, 10-to 12-week-old adult mice were injected intraperitoneally with phosphate-buffered saline (PBS) or a hemolytic agent, phenylhydrazine (PHZ; Sigma-Aldrich; Cat. #P26252; 60 mg/kg body weight), [18][19][20][21] followed by an iron absorption study 5 days later. Weanling mice used in some experiments were 21 to 23 days of age.…”
Section: Animal Proceduresmentioning
confidence: 99%
“…We previously reported relationships between T. erythraeum relative abundance levels and concentrations of maternal circulating inflammatory and metabolic biomarkers [35], and noted that although little is known about this species in the context of mammalian health, it is important for iron storage [74] and DNA protection against oxidative stress [75,76]. BCRP/Abcg2 can efflux porphyrin/haem in an effort to tightly regulate iron availability for host cellular metabolism and prevent toxicity [77,78]. Abundance levels of microbes will be influenced by iron availability, in part determined by mechanisms that regulate host iron biodisposition, including efflux transport.…”
Section: Discussionmentioning
confidence: 99%