Expression of ADAMTS 1‐4‐8 and placental growth factor in ovary and oviduct during pregnancy in the first trimester

Tatar, Musa; Tüfekci, Kıymet Kübra; Uslu, Sema; Öner, Jale

doi:10.1111/ahe.12922

Cited by 7 publications

(5 citation statements)

References 29 publications

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“…In ovaries, we observed up-regulation of genes related to the process of ovulation, corpus luteum formation, and implantation of the embryo, as indicated by adamts [49] and vcan [50].…”

Section: Genes Enrichedmentioning

confidence: 87%

Multi-Organ Nutrigenomic Effects of Dietary Grapes in a Mouse Model

Dave,

Park,

Pezzuto

2023

Antioxidants

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As a whole food, the potential health benefits of table grapes have been widely studied. Some individual constituents have garnered great attention, particularly resveratrol, but normal quantities in the diet are meniscal. On the other hand, the grape contains hundreds of compounds, many of which have antioxidant potential. Nonetheless, the achievement of serum or tissue concentrations of grape antioxidants sufficient to mediate a direct quenching effect is not likely, which supports the idea of biological responses being mediated by an indirect catalytic-type response. We demonstrate herein with Hsd:ICR (CD-1® Outbred, 18–24 g, 3–4 weeks old, female) mice that supplementation of a semi-synthetic diet with a grape surrogate, equivalent to the human consumption of 2.5 servings per day for 12 months, modulates gene expression in the liver, kidney, colon, and ovary. As might be expected when sampling changes in a pool of over 35,000 genes, there are numerous functional implications. Analysis of some specific differentially expressed genes suggests the potential of grape consumption to bolster metabolic detoxification and regulation of reactive oxygen species in the liver, cellular metabolism, and anti-inflammatory activity in the ovary and kidney. In the colon, the data suggest anti-inflammatory activity, suppression of mitochondrial dysfunction, and maintaining homeostasis. Pathway analysis reveals a combination of up- and down-regulation in the target tissues, primarily up-regulated in the kidney and down-regulated in the ovary. More broadly, based on these data, it seems logical to conclude that grape consumption leads to modulation of gene expression throughout the body, the consequence of which may help to explain the broad array of activities demonstrated in diverse tissues such as the brain, heart, eye, bladder, and colon. In addition, this work further supports the profound impact of nutrigenomics on mammalian phenotypic expression.

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“…In ovaries, we observed up-regulation of genes related to the process of ovulation, corpus luteum formation, and implantation of the embryo, as indicated by adamts [49] and vcan [50].…”

Section: Genes Enrichedmentioning

confidence: 87%

Multi-Organ Nutrigenomic Effects of Dietary Grapes in a Mouse Model

Dave,

Park,

Pezzuto

2023

Antioxidants

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“…Previous research has shown that several ADAMTS proteins are expressed in human, mouse, and rat ovary, oviduct, placental and uterine tissues (Feng et al, 2021;Mani et al, 2019;Park et al, 2021;Qu & Khalil, 2022;Tatar et al, 2023).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown Namli Kalem et al, 2017). ADAMTS-1 may create a pregnancysupportive uterine environment by controlling the breakdown of the decidual ECM and the substantial vascular remodelling that occurs during implantation and placentation (Lee et al, 2014;Tatar et al, 2023). According to a sheep study, ADAMTS-1 is also responsible for forming new blood vessels that provide nutrients to the placenta and endometrium (Dunlap et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1‐4‐8 during the three trimesters of rat pregnancy at the maternal‐fetal interface

Tatar

Uslu

Öner

2023

Anat Histol Embryol

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The functional roles of the a disintegrin and metalloprotease with a thrombospondin type motifs (ADAMTS) gene family in reproductive physiology, reproductive organs developments and adult reproductive health are still under investigation. The expression of the anti‐angiogenic proteases ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 in placental angiogenesis at various stages of pregnancy also remains unclear. The purpose of this study was therefore to determine the localization and expression of the ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 proteins during the three stages of pregnancy in rats. Maternal‐fetal tissue samples were collected on Days 5, 12 and 19 of each trimester, corresponding to the first, second and third trimesters. The expression of placental growth factor (PlGF) and ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 at the maternal‐fetal interface was examined using immunohistochemistry and western blot at three distinct phases of pregnancy. ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 were detected in all three trimesters of pregnancy. The relative amount of PIGF increased in the first trimester and decreased significantly in the third trimester (p < 0.05). The expression of ADAMTS‐1 and ADAMTS‐4 was significantly higher in the second (p < 0.05) and third trimesters (p < 0.01) compared to the first trimester. However, no statistically significant change was observed in ADAMTS‐8 expression between trimesters. The ADAMTS exhibiting the highest expression during the first trimester was ADAMTS8. These findings indicate that the expression of ADAMTS‐1, ADAMTS‐4 and ADAMTS‐8 in the three different stages of rat pregnancy may be involved in the modulation of decidualization, morphogenesis and angiogenesis. Periodic changes in ADAMTS expression are thought to be regulated by gonadal steroids.

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“…The prepared sections were photographed under a light microscope (Zeiss, Axiolab) with a camera attachment. Staining intensities were evaluated as (-); no staining, (-/+); partial staining, (+); weak staining, (++); moderate staining, (+++); strong staining (Tatar et al, 2023;Tufekci et al, 2023).…”

Section: Immunohistochemical Analysismentioning

confidence: 99%

“…Ten randomly selected regions in brain tissue sections from each rat were graded semi-quantitatively using an objective magnification of 40X. The median H-score value was used to classify each region's expression level as either low or high (Numata et al, 2013;Tatar et al, 2023).…”

Section: Semi-quantitative Analysismentioning

confidence: 99%

The protective effect of N-acetylcysteine on hippocampal ferroptosis in an experimental obesity model

TÜFEKCİ,

TATAR

2023

Journal of Cellular Neuroscience and Oxidative Stress

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Ferroptosis is a non-apoptotic cell death closely related to a metabolic pathway involving iron overload, imbalanced glutathione metabolism, oxidative stress and lipid peroxidation damage. Obesity is closely associated with these imbalances. In this study, we aimed to investigate the effect of hippocampal ferroptosis in an obesity model and the potential role of N-acetylcysteine (NAC) against ferroptosis. A high-fat (60%) dietary pattern was used to establish an obesity model for 15 weeks. NAC was administered to NAC and Obese+NAC (ObNAC) groups by oral gavage at a dose of 150 mg/kg for 3 weeks. Glutathione peroxidase 4 (GPX4) and the cystine transporter solute carrier family 7- member 11 (SLC7A11) expression levels were investigated immunohistochemically to detect ferroptosis in hippocampal tissues. In the statistical analysis, H-scores of GPX4 and SLC7A11 in the hippocampus sections of the Ob group were significantly lower than in the control, NAC and ObNAC groups (p

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Expression of ADAMTS 1‐4‐8 and placental growth factor in ovary and oviduct during pregnancy in the first trimester

Cited by 7 publications

References 29 publications

Multi-Organ Nutrigenomic Effects of Dietary Grapes in a Mouse Model

Multi-Organ Nutrigenomic Effects of Dietary Grapes in a Mouse Model

Expression of placental growth factor and a disintegrin and metalloprotease with a thrombospondin type motifs 1‐4‐8 during the three trimesters of rat pregnancy at the maternal‐fetal interface

The protective effect of N-acetylcysteine on hippocampal ferroptosis in an experimental obesity model

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