Expression of adhesion molecules in primary B-cell gastric lymphoma and lymphoid follicles

Abstract

To determine whether primary B-cell gastric lymphoma (GL) is one entity, we examined the expression of three adhesion molecules in the microvasculature of lymphomas. Stromal cells, including vascular endothelial cells, within lymphoid follicies of the gastric mucosa were also investigated. Twenty-two surgical specimens of GL were classified into low-grade malignant lymphoma arising from mucosa-associated lymphoid tissue (low-grade lymphoma, n = 9), and high-grade malignant lymphoma with (secondary high-grade lymphoma, n = 6) or without (primary high-grade lymphoma, n = 7) a low-grade component. The proportion of venules positive for ELAM-1 or VCAM-1 was significantly higher (P < 0.001) in primary high-grade lymphoma than in low-grade and secondary high-grade lymphomas. In gastric lymphoid follicles, the stromal cells of the germinal centre (GC) were positive for ICAM-1, ELAM-1, and VCAM-1, but the stromal cells of the marginal zone (MZ) were positive only for ICAM-1. We found two patterns of adhesion molecule expression in gastric lymphoid follicles, the MZ pattern and the GC pattern. Low-grade and secondary high-grade lymphomas, which had the MZ pattern, might be of MZ-cell lineage, but most primary high-grade lymphomas, which had the GC pattern, might be of follicular centre cell lineage.

Review of the molecular profile and modern prognostic markers for gastric lymphoma: How do they affect clinical practice?

“…In most primary highgrade GLs, the stromal cells of the germinal centre are positive for ICAM-1, ELAM-1 and VCAM-1 (germinal centre pattern), whereas in low-grade and secondary high-grade GLs, the stromal cells of the marginal zone are positive only for ICAM-1 (marginal zone pattern). 64 The observation that low-grade and secondary high-grade GLs present the marginal zone pattern, while most primary high-grade gastric GLs present the germinal centre pattern, is of exceptional significance, since it suggests that low-grade and secondary high-grade lymphomas are of marginal zone cell lineage, whereas most of the high-grade primary lymphomas are of germinal centre cell lineage.…”

Polymorphisms in the 3'-untranslated region of the CDH1 gene are a risk factor for primary gastric diffuse large B-cell lymphoma

“…[13][14][15][16][17] Inactivation is linked to different types of malignant tumors, [18][19][20][21][22][23][24][25][26][27] especially hereditary diffuse gastric cancer. [28][29][30][31][32] Primary gastric extranodal marginal zone lymphomas of MALT type and primary gastric diffuse large B-cell lymphomas express different patterns of adhesion molecules, 33 and B-cell tumor growth and clinical aggressiveness are related to the adhesive capacities of the tumor cells. 34 E-cadherin is expressed on lymphoma cells of patients with nonHodgkin's lymphoma 35 and is released into the blood.…”