Expression of alien histocompatibility antigens on SJL/J tumors detected by cell-mediated and serological analyses

Bonavida, Benjamin; Roman, Janet M.

doi:10.1007/bf00199262

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…The phenotypic alteration of MHC (major histocompatibility complex) antigens has been well documented in a variety of spontaneous and chemically induced tumor cells (Rogers et al, 1979;Bonavida et al, 1981;Callahan et al, 1983) and in virally transformed cells (Mellow ef al., 1984;Majello et al, 1985;Guy et al, 1986). A similar alteration in MHC antigens would appear possible in HTLV-I-infected or -transformed T cells.…”

Section: Discussionmentioning

confidence: 99%

Altered HLA antigens expressed on T and B lymphocytes of adult T‐cell leukemia/lymphoma patients and their relatives

Sonoda

Yashiki

Takahashi

et al. 1987

Intl Journal of Cancer

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The HLA types of peripheral blood lymphocytes (PBL) of 36 adult T-cell leukemia/lymphoma (ATLL) patients were examined and compared with those of 45 healthy relatives of these patients, and with those of 10 non-ATLL families including 80 healthy members. Thirty-one percent of ATLL patients showed either a gain or a loss of HLA antigens determined by the presence of alien HLA antigens or the absence of inherent HLA antigens deduced from familial haplotype analysis. The antigen specificity of HLA gained or lost was variable and differed from case to case among ATLL patients. Although the gain of HLA was detected only in ATLL patients, the loss of HLA was found both in ATLL patients and in asymptomatic healthy relatives. The rate of HLA loss in ATLL patients (8.4%) and their relatives (17.8%) was much higher than in relatives of non-ATLL patients (1.1%). The HLA gain and loss revealed in the PBL of ATLL patients were confirmed by altered HLA phenotypes in the cloned T and B cells established from ATLL patients. Our results suggest that latently infecting HTLV-I may induce altered HLA phenotypes in T and B cells, primarily with loss of HLA antigens in a population of asymptomatic virus carriers, and secondarily with a gain of HLA antigens after the development of ATLL.

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Section: Discussionmentioning

confidence: 99%

Altered HLA antigens expressed on T and B lymphocytes of adult T‐cell leukemia/lymphoma patients and their relatives

Sonoda

Yashiki

Takahashi

et al. 1987

Intl Journal of Cancer

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Intimate host-tumor interaction in the spontaneous reticuium cell sarcoma of SJL/J mice: Is it an exceptional case?

Bonavida

1985

Surv. immunol. Res.

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The SJL/J Spontaneous Reticulum Cell Sarcoma: New Insights in the Fields of Neoantigens, Host-Tumor Interactions, and Regulation of Tumor Growth

Bonavida¹

1983

Advances in Cancer Research

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Expression of alien histocompatibility antigens on SJL/J tumors detected by cell-mediated and serological analyses

Abstract: Summary. Reticulum cell sarcoma (RCS) cells of SJL/J (H-2 s) mice have been shown to express antigens that are cross-reactive with allogeneic cells of the H-

Cited by 5 publications

References 15 publications

Altered HLA antigens expressed on T and B lymphocytes of adult T‐cell leukemia/lymphoma patients and their relatives

Altered HLA antigens expressed on T and B lymphocytes of adult T‐cell leukemia/lymphoma patients and their relatives

Intimate host-tumor interaction in the spontaneous reticuium cell sarcoma of SJL/J mice: Is it an exceptional case?

The SJL/J Spontaneous Reticulum Cell Sarcoma: New Insights in the Fields of Neoantigens, Host-Tumor Interactions, and Regulation of Tumor Growth

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