Expression of an “Activator” RNA Hybridizable to the SV40 Promoter Correlates with the Transformed Phenotype of Mouse and Human Cells

An RNA polymerase III transcript, 7SK nuclear RNA, was found to bear sequence homology to the B2 class of highly repeated elements in the mouse genome. Northern blot hybridizations between the small RNAs and two B2 clones showed that only one of them (p49C8) hybridized to 7SK RNA. Both clones, however, hybridized to 4.5SI RNA as well as to a third class of nuclear RNA transcripts around 170 nucleotides long, whose levels were found to be greatly increased upon induction of transformation in a mouse 3T3 cell line transformed with a temperature-sensitive mutant of simian virus 40.

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Localization of small RNAs hybridizable to a B2 clone in the nuclear fraction of mouse cell lines

Gallant

Lovely

Krause

1987

Mol Biol Rep

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Expression of an “Activator” RNA Hybridizable to the SV40 Promoter Correlates with the Transformed Phenotype of Mouse and Human Cells

Cited by 1 publication

References 14 publications

Localization of small RNAs hybridizable to a B2 clone in the nuclear fraction of mouse cell lines

Localization of small RNAs hybridizable to a B2 clone in the nuclear fraction of mouse cell lines

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