Expression of an altered cAMP binding protein by rapid-developing strains of Dictyostelium discoideum

Tsang, Adrian; Kay, Carolyn A.; Tasaka, Masao

doi:10.1016/0012-1606(87)90126-6

Cited by 8 publications

(1 citation statement)

References 24 publications

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“…In the analysis of FR17, the supposition has been that an event fundamental to all steps of Dictyosteliuin development is deranged. An intracellular cAMP-binding protein other than the one associated with the protein kinase has been detected (244), and while it may be altered in the V12 strain, a wild-type isolate which develops several hours faster than the standard NC4 strain, it appears to be normal in the FR17 strain (243).…”

Section: Mutations That Affect Many Eventsmentioning

confidence: 99%

Genetics of early Dictyostelium discoideum development.

Kessin¹

1988

Microbiological Reviews

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Dictyostelium amoebae feed on bacteria and divide by binary fission as long as their prey is available. Once their food is exhausted or removed, the cells begin development and synthesize new macromolecules that give them the ability to move toward sources of cyclic adenosine 3',5'phosphate (cAMP). All of the apparatus required for recognizing cAMP and moving up a concentration gradient, including the cAMP receptor (106, 130, 131), extracellular cyclic nucleotide phosphodiesterase (97, 126, 185), adenylate cyclase (60, 127, 205), and cAMP secretory apparatus, are produced de novo (144). During their migration into centers of aggregation, the cells become adhesive, and once assembled, they unleash a large number of new transcripts, of the wave is reduced by diffusion and the actions of membrane-bound and secreted cyclic nucleotide phosphodiesterase (see reference 137 for the history of this enzyme). The successive waves of cAMP, which travel outward at a velocity of about 300 p.m/min, have been observed by an elegant isotope dilution technique (242). The reason for the

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Section: Mutations That Affect Many Eventsmentioning

confidence: 99%

Genetics of early Dictyostelium discoideum development.

Kessin¹

1988

Microbiological Reviews

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Characterization of an unusual cAMP receptor and its related polypeptides in Dictyostelium discoideum

et al. 1988

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Several lines of evidence indicate that cAMP modulates developmental gene activity via cell-surface receptors. We describe here a novel cAMP receptor, CABP1, whose properties are consistent with the idea that this protein is involved in gene regulation. Firstly, immunological techniques using anti-CABP1 antibodies as probes showed that this cAMP receptor can be detected on the surface of developing cells. Secondly, there is a steady migration of CABP1 to the nucleus during development. Thirdly, some genetic variants exhibiting an altered pattern of development are found to possess modified CABP1. We also showed that CABP1 co-purifies with at least seven other polypeptides which share common epitopes with CABP1. Interestingly, four of the CABP1-related polypeptides can be detected on the cell surface as well as in the nucleus.

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