2013
DOI: 10.1371/journal.pone.0077505
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Expression of an Engineered Heterologous Antimicrobial Peptide in Potato Alters Plant Development and Mitigates Normal Abiotic and Biotic Responses

Abstract: Antimicrobial cationic peptides (AMPs) are ubiquitous small proteins used by living cells to defend against a wide spectrum of pathogens. Their amphipathic property helps their interaction with negatively charged cellular membrane of the pathogen causing cell lysis and death. AMPs also modulate signaling pathway(s) and cellular processes in animal models; however, little is known of cellular processes other than the pathogen-lysis phenomenon modulated by AMPs in plants. An engineered heterologous AMP, msrA3, e… Show more

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Cited by 40 publications
(21 citation statements)
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“…Another approach might consist of molecular engineering of specific genes and their introduction into crop plants. By modifying a gene coding for a small antimicrobial peptide and introducing it into potato, the resistance of potato to biotic and abiotic stress was increased [ 130 ].…”
Section: Discussionmentioning
confidence: 99%
“…Another approach might consist of molecular engineering of specific genes and their introduction into crop plants. By modifying a gene coding for a small antimicrobial peptide and introducing it into potato, the resistance of potato to biotic and abiotic stress was increased [ 130 ].…”
Section: Discussionmentioning
confidence: 99%
“…The effect of both types of prosystemin types can be explained assuming that these precursors go through multiple processing events in tobacco, which may lead to a direct or indirect activation of oxidative stress defense mechanisms (Albert 2013;Pearce et al 2010;Schmelz et al 2006). In potato, the expression of a modified heterologous antimicrobial peptide precursor provided resistance against plant pathogens but, unexpectedly, altered also the plant ROS response to stress (Goyal et al 2013). These data open the intriguing possibility that plant cells sense the constitutive expression of heterologous prohormones as a chronic perturbation of protein homeostasis, activating some molecular stress responses (Morimoto 2008).…”
Section: Discussionmentioning
confidence: 99%
“…The use of plants as biofactories for AMPs might represent an economical and safe alternative. Although, the production of these bioactive peptides in plant systems has been challenging due to either instability or degradation in plant tissues [ 14 , 16 , 17 ], or to phytotoxicity that results in a penalty on plant performance [ 18 21 ]. Rice seeds offer unique opportunities as bioreactors since the rice gene transfer technology is well developed, cropping conditions are easy and well-established worldwide, and high grain yield can be obtained [ 22 , 23 ].…”
Section: Introductionmentioning
confidence: 99%