Expression of an oscillating interferon-γ receptor in the suprachiasmatic nuclei

Lundkvist, Gabriella B.; Robertson, Brita; Mhlanga, Jama; Rottenberg, Martı́n E.; Kristensson, Krister

doi:10.1097/00001756-199804200-00018

Cited by 63 publications

(31 citation statements)

References 8 publications

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“…In this sense, Nishiuchi et al [31] showed that there were no differences in tissue distribution after murine recombinant IFN-gamma administration in mice, rats or hamsters, suggesting an absence of species specificity between them. The finding that the IFN-gamma receptor is expressed in the SCN [24,32] suggests that the effects seen could be exerted directly by IFN-gamma in the SCN. However, another hypothesis cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

“…A light-dependent immunopositivity for the IFN-gamma receptor is detectable in the SCN, its expression displaying a daily rhythm with a peak at Zeitgeber time (ZT) 15 (with ZT 12 defined arbitrarily as the time of lights off) [24]. Furthermore, in rats the locomotor activity and rearing were reduced following central administration of IFNgamma even 7 days after injection [25].…”

Section: Introductionmentioning

confidence: 99%

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Cerebroventricular Administration of Interferon-Gamma Modifies Locomotor Activity in the Golden Hamster

et al. 2003

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The present study was undertaken to examine whether the intracerebroventricular (i.c.v.) administration of interferon (IFN)-gamma could modify 24-hour wheel running locomotor activity in the golden hamster. Hamsters implanted with a cannula in the third ventricle received a single i.c.v. injection of 1 µl of murine recombinant IFN-gamma (40 IU/µl) or its vehicle (saline) at ZT 6 or ZT 18 (with ZT 12 defined arbitrarily as the time of lights off) and their activities were monitored during 24 h. The i.c.v. administration of IFN-gamma at ZT 6 produced a significant phase advance in acrophase of rhythm, an effect not seen at ZT 18. Also, IFN-gamma depressed mesor value significantly, the effect was seen at both times. These results clearly showed that the circadian clock could be modified by IFN-gamma microinjections. One explanation could be the presence of IFN-gamma receptor in the rat suprachiasmatic nucleus, supporting a direct effect on the central oscillator. However, another hypothesis could not be ruled out.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cerebroventricular Administration of Interferon-Gamma Modifies Locomotor Activity in the Golden Hamster

et al. 2003

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“…Alternatively, IFN-Á could modify the activity of sympathetic nerves, which, in turn, would modulate LPS or Con A responses. In addition, there is indication on the expression of an oscillating IFN-Á receptor in the ventrolateral parts of the suprachiasmatic nuclei, the major circadian oscillator in the CNS, supporting the view that the pacemaker of the biological clock can be influenced by the cytokine [67].…”

Section: Local Sympathectomy Influences Specific Responses In Immune mentioning

confidence: 75%

Psychoimmune Neuroendocrine Integrative Mechanisms Revisited

Cardinali¹,

Cutrera²,

Esquifino³

2000

Neurosignals

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This review analyzes recent publications on the topic of psycho-immune-neuroendocrine integrative mechanisms. Results on the role of cytokines in cognitive processes and in a major neuroendocrine event, i.e. the release of gonadotropin-releasing hormone, are discussed, as are the effects of cytokines on central neurotransmission. The control of immune responses by local sympathetic nerves, a major pathway in neuroimmune communication, is discussed. This review also updates information indicating that melatonin is a circulating signal affecting the periodic organization of the immune response.

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“…Accumulating evidence demonstrates that a decreased Th1 immune response is also important in the pathogenesis of allergic diseases, and that interferon-γ (IFN-γ) could act as a central regulator in this phenomenon [32]. On the other hand, a light-dependent immunopositivity for the IFN-γ receptor is detectable in the SCN [33]. Accordingly, Th1/Th2 balance-related cytokines, such as IFN-γ, might thus be associated with the outcome.…”

Section: Discussionmentioning

confidence: 99%

Lesions in the Suprachiasmatic Nuclei Suppress Inflammatory Mediators in Sensitized Rats

Irie

Endo

2006

Int Arch Allergy Immunol

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Background: Although bronchial asthma is well known as an inflammatory disease that shows obvious circadian rhythms of airway narrowing, it remains to be elucidated whether the suprachiasmatic nucleus (SCN), a major circadian pacemaker, regulates inflammatory mediators relevant to asthma. Thus, we investigated the effects of electrolytic lesioning of the SCN on the antigen-induced immediate allergic response and the late allergic response (LAR) in male Brown Norway rats, i.e. in a model of allergic inflammation. Methods: The immediate allergic response, assessed by the histamine levels in plasma and bronchoalveolar lavage fluid (BALF), and the LAR, assessed by the eosinophilic infiltration into BALF and the lamina propria mucosae of the left main bronchus, were examined in three groups of 18 rats each, including (1) an unoperated control group, (2) a sham SCN-lesioned group, and (3) an SCN-lesioned group. Results: Both the plasma histamine levels and the number of eosinophils in bronchial tissues in the SCN-lesioned group were significantly lower than those in the other groups. The concentration of histamine and the number of eosinophils in the right BALF showed a similar pattern; however, no significant differences were found. Both plasma adrenaline and noradrenaline levels were highest during the LAR, whereas the corticosterone level was lowest in the SCN-lesioned group; again, no significant differences were obtained. Conclusions: These findings indicate that the SCN has a significant effect on the inflammatory mediators relevant to bronchial asthma.

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Expression of an oscillating interferon-γ receptor in the suprachiasmatic nuclei

Cited by 63 publications

References 8 publications

Cerebroventricular Administration of Interferon-Gamma Modifies Locomotor Activity in the Golden Hamster

Cerebroventricular Administration of Interferon-Gamma Modifies Locomotor Activity in the Golden Hamster

Psychoimmune Neuroendocrine Integrative Mechanisms Revisited

Lesions in the Suprachiasmatic Nuclei Suppress Inflammatory Mediators in Sensitized Rats

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