Expression of angiomodulin (tumor-derived adhesion factor/mac25) in invading tumor cells correlates with poor prognosis in human colorectal cancer

Adachi, Yasushi; Itoh, Fumio; Yamamoto, Hiroyuki; Arimura, Yoshiaki; Kikkawa-Okabe, Yukie; Miyazaki, Kaoru; Carbone, David P.; Imai, Kohzoh

doi:10.1002/1097-0215(20010720)95:4<216::aid-ijc1037>3.0.co;2-o

Cited by 42 publications

(39 citation statements)

References 23 publications

(30 reference statements)

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“…Our study suggested that IGFBP7 positivity was associated with a better prognosis, which contradicts the study by Adachi et al (11). Although IGFBP7 did not correlate with the macrophage in the invasive margin (data not shown), the results of cluster analysis showed that IGFBP7 was close to macrophages in the invasive margin.…”

Section: Discussioncontrasting

confidence: 99%

Classification Based on the Combination of Molecular and Pathologic Predictors is Superior to Molecular Classification on Prognosis in Colorectal Carcinoma

Wang

et al. 2007

Clinical Cancer Research

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Purpose: Classification based on a combination of molecular and pathologic predictors had never been done using hierarchical cluster analysis. For this purpose, we identified prognostic classification based on molecular predictors, pathologic and molecular predictors, and compared their respective prognostic efficacy together with that of tumor-node-metastasis (TNM) stage. Moreover, we investigated the prognostic significance of molecular classification in different TNM stage. Experimental Design: Six pathologic predictors (p) and 13 immunohistochemical predictors (m) were investigated in 221colorectal carcinomas. Unsupervised hierarchical clustering analysis was done to group the data. Survival analysis was done by Kaplan-Meier method and log-rank test, and by multivariate COX proportional hazard model. Results: Six pathologic predictors and four molecular predictors were of significant prognostic value (P V 0.05). One molecular predictor showed a trend toward significance (P = 0.085). Hierarchical clustering analysis was done based on different combinations (5p, 13m, 5m, 5p13m, and 5p5m), and distinct groups were produced except 5p (the TNM stage was excluded). Groups identified by 5m (P = 0.053) and 5p5m (P = 0.000) showed significant differences in prognosis. Groups identified by 5p5m andTNM stage were confirmed as the independent prognostic factors in a multivariate COX proportional hazard model. Moreover, groups identified by 5m could predict different prognoses in patients with stage II disease. Conclusions: Classification based on pathologic and immunohistochemical predictors is superior to that based only on molecular predictors on prognosis. Classification based on 5m could identify additional different prognoses in patients with stage II disease.Colorectal carcinoma is one of the leading causes of cancer mortality worldwide. Accurate prognosis analysis will greatly facilitate clinical decision of the best treatment plan and reduce the healthcare costs. Up to now, tumor-node-metastasis (TNM) staging has remained the most widely used system, but the patients operated on at the same TNM stage do not necessarily have the same prognosis. Recently, with the identification of numerous molecular predictors, a more accurate staging system is expected. There have been endeavors to build a prognostic evaluation system based on molecular markers. For example, Lyall et al. identified a prognostic immunohistochemical marker profile in 90 stage III colorectal carcinomas by unsupervised hierarchical cluster analysis of 23 markers (1). Knosel et al. evaluated 11 immunohistochemical markers in 270 colorectal carcinomas (2). However, because the pathologic and molecular predictors were always classified separately in the past (1 -5), it is still unknown whether the molecular staging system would yield more accurate prognosis analyses than the traditional TNM staging system.Unsupervised hierarchical clustering analysis is a common method to profile the gene expression or tissue microarray data. For example, it h...

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Section: Discussioncontrasting

confidence: 99%

Classification Based on the Combination of Molecular and Pathologic Predictors is Superior to Molecular Classification on Prognosis in Colorectal Carcinoma

Wang

et al. 2007

Clinical Cancer Research

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“…Tumor samples with upregulated expression of IGFBP-rP1 in invading tumor cells showed an increased frequency of metastasis to lymph nodes and an increased depth of infiltration. This finding complements that of Adachi et al (2001). They found that high expression of IGFBP-rP1/AGM in invasive tumor cells is associated with poor prognosis.…”

Section: Discussionsupporting

confidence: 75%

Detection of the differentially expressed gene IGF-binding protein-related protein-1 and analysis of its relationship to fasting glucose in Chinese colorectal cancer patients.

Shao

Huang

Luo

et al. 2004

Endocr Relat Cancer

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IGF-binding protein-related protein-1 (IGFBP-rP1) is a member of the IGF axis. In our previous work, we separated cDNA fragments of IGFBP-rP1 from colonic adenocarcinoma and normal mucosa cDNA subtraction libraries. In this study, we compared the expression of IGFBP-rP1 by semi-quantitative RT-PCR and immunohistochemistry among colorectal cancer, adenoma, normal tissue adjacent to cancer site, and normal tissue. Associations between IGFBP-rP1 and plasma glucose were further explored. We found that the mRNA level of IGFBP-rP1 was highest in cancer, moderate in adenoma and tissue adjacent to the cancer site and lowest in normal tissue ðP < 0:05Þ. A significant difference was found in the immunoreactivity of IGFBP-rP1 between paired normal and cancer tissue ðP < 0:05Þ. Tumor samples with upregulated expression of IGFBP-rP1 in invading tumor cells showed an increased frequency of metastasis to the lymph node, an increased depth of infiltration and stronger staining of IGFBP-rP1 compared with other samples ðP < 0:05Þ. The fasting glucose level was significantly correlated with the staining of IGFBP-rP1 in cancer tissue (Spearman's rho = 0.4, P < 0.000). Thus, we concluded overexpression of IGFBP-rP1 might play an important role in the initiation and promotion of colorectal cancer. IGFBP-rP1 expression may also be associated with fasting glucose level and the presence of diabetes mellitus.

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“…This was considered possibly to relate to the effectiveness of IGFBP7 in promoting apoptosis. However, our findings contrast with the results of Adachi et al (27), who found that high expression of IGFBP7 in invasive tumor cells was associated with poor prognosis. This discrepancy may be due to the difference in the immunohistochemical scoring (21,28).…”

Section: Discussioncontrasting

confidence: 99%

Intratumoral injection of pEGFC1-IGFBP7 inhibits malignant melanoma growth in C57BL/6J mice by inducing apoptosis and down-regulating VEGF expression

Ту¹

2010

Oncol Rep

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Abstract. Malignant melanoma (MM) is a type of aggressive skin cancer, and the effective therapy for MM is highly desired. Recently, genome-wide RNA interference screening study revealed that loss of expression of insulin-like growth factor binding protein 7 (IGFBP-7) is a critical step in development of MM, and this secreted protein plays a central role in apoptosis of MM. Furthermore, a prostatic carcinoma cell line stably transfected with IGFBP-7 cDNA showed poor tumorigenicity. Thus, we supposed it to be an efficacious agent for inhibiting melanomas. In this study, we constructed pEGFC1-IGFBP7 to try to obtain high expression of IGFPB7 and then we demonstrated that this plasmid inhibited proliferation of B16-F10 melanoma cells efficiently in vitro. Moreover, intratumoral injection of pEGFC1-IGFBP7 inhibited MM growth in C57BL/6J mice. The inhibition of MM growth is due to apoptosis and reduced expression of VEGF induced by pEGFC1-IGFBP7. These results suggest a potential new clinical strategy for MM treatment.

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Expression of angiomodulin (tumor-derived adhesion factor/mac25) in invading tumor cells correlates with poor prognosis in human colorectal cancer

Cited by 42 publications

References 23 publications

Classification Based on the Combination of Molecular and Pathologic Predictors is Superior to Molecular Classification on Prognosis in Colorectal Carcinoma

Classification Based on the Combination of Molecular and Pathologic Predictors is Superior to Molecular Classification on Prognosis in Colorectal Carcinoma

Detection of the differentially expressed gene IGF-binding protein-related protein-1 and analysis of its relationship to fasting glucose in Chinese colorectal cancer patients.

Intratumoral injection of pEGFC1-IGFBP7 inhibits malignant melanoma growth in C57BL/6J mice by inducing apoptosis and down-regulating VEGF expression

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