Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia

Hou, Hsin‐An; Chou, Wen‐Chien; Lin, Liang-In; Tang, Jih-Luh; Tseng, Mei‐Hsuan; Huang, Chih‐Fen; Yao, Ming; Chen, Chien-Yuan; Tsay, Woei; Tien, Hwei‐Fang

doi:10.1016/j.leukres.2007.08.010

Cited by 56 publications

(54 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hou et al 17 reported that high pre-transplant levels of Ang2 correlated with poor prognosis, but its role as predictor of the OS or nonrelapse mortality is still controversial. 17,18 According to Kü mpers et al, 18 high pretransplant levels of Ang2 were associated with an unfavorable prognosis, and they suggested that it could function as a marker for the risk of relapse. The median age of the patients was 54 and they were all diagnosed with either AML or myelodysplastic syndrome.…”

Section: Discussionmentioning

confidence: 99%

Higher angiopoietin-2 and VEGF levels predict shorter EFS and increased non-relapse mortality after pediatric hematopoietic SCT

Porkholm

Bono

Saarinen-Pihkala

et al. 2012

Bone Marrow Transplant

View full text Add to dashboard Cite

The roles of angiogenesis and angiogenic factors after allogenic hematopoietic SCT (HSCT) and during acute GVHD (aGVHD) are not known. Studies on pediatric patients are extremely scarce. Levels of angiopoietin-2 (Ang2) and vascular endothelial growth factor (VEGF) were analyzed from blood samples of 67 consecutive patients. The levels were correlated with aGVHD grades, routine laboratory parameters and outcome. Pre-transplant Ang2 values correlated with the occurrence of intestinal aGVHD (P ¼ 0.009), whereas post-transplant measurements correlated with the severity of skin and liver aGVHD (P ¼ 0.03, P ¼ 0.04, respectively). Pre-transplant levels of VEGF were associated with the occurrence of skin aGVHD (P ¼ 0.04), whereas post-transplant levels correlated to the severity of intestinal aGVHD (P ¼ 0.04). High Ang2 levels were associated with shorter EFS (P ¼ 0.039) and increased non-relapse mortality (NRM) (P ¼ 0.009). In conclusion, higher Ang2 levels predict higher NRM and, with coexisting high VEGF, also shorter EFS after pediatric HSCT. Our results suggest that both pre-and post-transplant levels of Ang2 and VEGF seem to correlate to the clinical state of the patient. However, the pathophysiology of this connection needs further studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Higher angiopoietin-2 and VEGF levels predict shorter EFS and increased non-relapse mortality after pediatric hematopoietic SCT

Porkholm

Bono

Saarinen-Pihkala

et al. 2012

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…Ang-1, Ang-2 and Tie2 levels have been extensively studied in AML patients [12][13][14][15]. According to the results, Ang-2 was found to be elevated in AML patients as compared to controls and Ang-2 was proved to be an independent prognostic factor in AML [13].…”

Section: Introductionmentioning

confidence: 98%

Serum Angiopoietin Levels are Different in Acute and Chronic Myeloid Neoplasms: Angiopoietins do not only Regulate Tumor Angiogenesis

Atesoglu

Tarkun

Mehtap

et al. 2015

Indian J Hematol Blood Transfus

View full text Add to dashboard Cite

Molecular balance between Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) has important effects in tumor angiogenesis. Ang-2 was shown to be elevated and proved to be a prognostic factor in acute myeloid leukemia (AML). To date studies revealed increased angiogenesis in bone marrows (BMs) of both myeloproliferative neoplasm (MPN) and AML patients. We conducted this study to demonstrate circulating levels of Ang-1 and Ang-2 in MPN patients since no data exists in literature. Thirty-three newly diagnosed MPN, 27 newly diagnosed AML patients and 25 controls (HC) were enrolled and Angiopoietin levels were determined with ELISA. We found that Ang-1 levels were higher whereas Ang-2 levels were lower in MPN and HC when compared to AML. Our results suggest that though angiogenesis is increased in both AML and MPN, angiopoietin serum level profile of the two diseases are different, and MPN patients have similar Ang-1 and Ang-2 levels as HC. We conclude that, according to our results Ang-1 and Ang-2 do not only regulate tumor angiogenesis and the difference between angiopoietin levels of acute and chronic myeloid neoplasms could be a reflection of other effects of these growth factors on tumor malignancy.

show abstract

“…High FOXO3a expression is associated with a poorer prognosis in CN-AML (Santamaria et al, 2009) and the increased levels of both total and of highly phosphorylated FOXO3a correlate with higher proliferation and blood blasts and these high levels of FOXO3a are an adverse prognostic factor in AML (Kornblau et al, 2010). Bone marrow neoangiogenesis plays an important pathogenetic and possible prognostic role in AML (Hou et al, 2008;Lee et al, 2007;Loges et al, 2005;Mourah et al 2009). Multivariable analysis showed that the levels of vascular endothelial growth factor (VEGF) transcript isoform 121 (VEGF121) remained an independent prognostic factor for either event-free survivasl or overall survival (Mourah et al, 2009).…”

Section: Other Molecular Marker Genes Expressionmentioning

confidence: 99%

“…High levels of VEGF121 were significantly related to a worse prognosis. Angiopoietin-2 (Ang2) gene expression represents also an independent prognostic factor in AML with intermediate risk and high Ang2 expression is associated with an unfavorable prognosis (Hou et al, 2008;Lee et al, 2007;Loges et al, 2005). High VEGFC expression appeared strongly associated with reduced complete remission rate, reduced overall and event-free survival in adult AML independent of cytogenetic risk and white blood cell count (de Jonge et al, 2010).…”

Section: Other Molecular Marker Genes Expressionmentioning

confidence: 99%

Molecular Markers for Risk Stratification in Adult Acute Myeloid Leukemia with Normal Cytogenetics

Fuchs¹

2011

Acute Leukemia - The Scientist's Perspective and Challenge

View full text Add to dashboard Cite

Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia

Cited by 56 publications

References 38 publications

Higher angiopoietin-2 and VEGF levels predict shorter EFS and increased non-relapse mortality after pediatric hematopoietic SCT

Higher angiopoietin-2 and VEGF levels predict shorter EFS and increased non-relapse mortality after pediatric hematopoietic SCT

Serum Angiopoietin Levels are Different in Acute and Chronic Myeloid Neoplasms: Angiopoietins do not only Regulate Tumor Angiogenesis

Molecular Markers for Risk Stratification in Adult Acute Myeloid Leukemia with Normal Cytogenetics

Contact Info

Product

Resources

About