Expression of anoikis-related genes and potential biomarkers in colon cancer

Abstract

Colon cancer (CC) is a malignant tumor of the digestive tract with an increasing incidence and poor prognosis. Previous studies have shown that anovulation apoptosis plays a crucial role in the occurrence and development of cancer. However, the expression pattern of anovulatory apoptosis-related genes (ANRGs) in the CC subtype and its relationship with immunity is still unclear. This study aims to explore the role of ANRGs in the CC subtype and their relationship with the prognosis of colon cancer. Transcriptome data and clinical data of CC patients were obtained from the TCGA database and GEO database. Then, this paper divides the samples into two subtypes by consensus clustering. The prognosis of the two subtypes is significantly different.We found that multiple ANRGs played a vital role in the prognosis of colon cancer. In addition, we developed an ANRGs risk model for CC. Patients were divided into the high-risk group and the low-risk group according to the risk score. There are significant differences in survival and immune landscape between the two groups. The ANRGs related to prognosis and risk scores obtained in this paper can provide a basis for the treatment of CC.