Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression

Stavropoulos, Aggelis; Varras, M; Vasilakaki, Thivi; Varra, Viktoria‐Konstantina; Varra, Fani‐Niki; Tsavari, Aikaterini; Nonni, Afrodite; Kavantzas, Nikolaos; Lazaris, Andreas C.

doi:10.3892/ol.2020.11690

Cited by 5 publications

(3 citation statements)

References 71 publications

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“…Traditionally, prognostic factors for EC include surgical stage, histological factors [ 22 , 23 ], and molecular factors such as P53 mutation [ 24 ]. This information is often only available from histological evaluation after surgery, so preoperative risk assessment of recurrence is limited.…”

Section: Discussionmentioning

confidence: 99%

MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis

et al. 2021

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Background To identify predictive value of apparent diffusion coefficient (ADC) values and magnetic resonance imaging (MRI)-based radiomics for all recurrences in patients with endometrial carcinoma (EC). Methods One hundred and seventy-four EC patients who were treated with operation and followed up in our institution were retrospectively reviewed, and the patients were divided into training and test group. Baseline clinicopathological features and mean ADC (ADCmean), minimum ADC (ADCmin), and maximum ADC (ADCmax) were analyzed. Radiomic parameters were extracted on T2 weighted images and screened by logistic regression, and then a radiomics signature was developed to calculate the radiomic score (radscore). In training group, Kaplan–Meier analysis was performed and a Cox regression model was used to evaluate the correlation between clinicopathological features, ADC values and radscore with recurrence, and verified in the test group. Results ADCmean showed inverse correlation with recurrence, while radscore was positively associated with recurrence. In univariate analyses, FIGO stage, pathological types, myometrial invasion, ADCmean, ADCmin and radscore were associated with recurrence. In the training group, multivariate Cox analysis showed that pathological types, ADCmean and radscore were independent risk factors for recurrence, which were verified in the test group. Conclusions ADCmean value and radscore were independent predictors of recurrence of EC, which can supplement prognostic information in addition to clinicopathological information and provide basis for individualized treatment and follow-up plan.

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Section: Discussionmentioning

confidence: 99%

MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis

et al. 2021

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“…Survivin can promote cell proliferation by inhibiting caspase activation and stabilizing microtubules during cell mitosis to protect cells from apoptosis (23). Previous studies have found that survivin is upregulated in a variety of human malignancies (24)(25)(26) and is associated with poor prognosis (27)(28)(29)(30), leading to proposals of survivin being used as a potential tumor marker and prognostic indicator. However, the significance of survivin in breast cancer progression remain controversial.…”

Section: Significance Of Combined Tgf-β1 and Survivin Expression On T...mentioning

confidence: 99%

Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer

Liu

Jiang

et al. 2022

Oncol Lett

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Compared with other types of breast cancer, triple-negative breast cancer (TNBC) has the characteristics of rapid progression, a lack of specific molecular targets for treatment and a poor prognosis. However, based on previously published studies, TGF-β1 and survivin are potentially meaningful for the prognosis of patients with TNBC. The present study was therefore designed to measure and compare the expression of transforming growth factor-β1 (TGF-β1) and survivin in tissue samples of TNBC and non-TNBC patients in order to evaluate their ability as prognostic indicators. In total, 90 TNBC and 52 non-TNBC tissue specimens were selected, following which immunohistochemistry was used to detect the expression of TGF-β1 and survivin in the cancer tissues. Subsequently, the potential association between the expression levels of these two proteins and the clinicopathological variables was analyzed. The expression levels of TGF-β1 and survivin in TNBC tissues were found to be significantly higher compared with those in the non-TNBC tissues. In addition, the results of the present study demonstrated that TGF-β1 expression was positively associated with survivin expression in the TNBC samples, but no significant correlation was found between TGF-β1 and survivin expression in the non-TNBC samples. Kaplan-Meier (K-M) analysis was performed to assess the levels of TGF-β1 and survivin in regard to patient survival, and univariate and multivariate Cox analyses of TGF-β1 and survivin protein expression were performed to analyze the overall survival (OS) and progression-free survival (PFS) rates of patients with TNBC and non-TNBC. Although multivariate Cox analysis demonstrated that neither TGF-β1 or survivin were independent prognostic predictors of TNBC or non-TNBC, results of the K-M curve revealed that patients with TNBC with TGF-β1-and survivin-positive breast cancer exhibited shorter OS and PFS times. Multivariate Cox analysis demonstrated that in patients with TNBC, the combined expression of TGF-β1 and survivin may yield additional prognostic information, compared with patients with non-TNBC.

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“…For histological analysis routine staining with hematoxylin and eosin was used, and a pathologist confirmed the pathological diagnosis and identified areas of tumor mass. The phosphatase and tensin homologue deleted on chromosome 10 (PTEN), p53 and survivin immunohistochemical staining was performed and evaluated as described previously (69,70). Immunohistochemical staining for IGF-1Ec was performed as follows: 4-µm-thick microtome sections were prepared from the paraffin-fixed samples, making sure to include a sufficient quantity of neoplasm mass, which was mounted on a silane-coated glass slides, dried at 37˚C overnight, dewaxed in xylene and rehydrated in serial dilutions of ethanol.…”

Section: Patientsmentioning

confidence: 99%

Immunohistochemical expression of insulin‑like growth factor‑1Ec in primary endometrial carcinoma: Association with PTEN, p53 and survivin expression

et al. 2020

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Chronic hyperinsulinemia due to insulin resistance and elevated levels of insulin-like growth factor (IGF)-1 and IGF-2 are suggestive of a significantly higher risk of endometrial carcinoma. There is a wealth of evidence showing differential expression of IGF-1 isoforms in various types of cancer. In the present study, 99 archived endometrial carcinoma tissue sections were retrospectively assessed by immunohistochemistry for IGF-1Ec isoform expression. Expression of IGF-1Ec was also assessed in nine cases of non-neoplastic endometrial tissue adjacent to the tumor, in 30 cases with normal endometrium and in 30 cases with endometrial hyperplasia. Furthermore, the association between IGF-1Ec and the concurrent expression of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), p53 or survivin was assessed, as well as their combined expression in association with clinicopathological variables. In endometrial carcinoma, IGF-1Ec expression was high in non-endometrioid carcinoma (serous papillary or clear cell carcinoma) compared with that in endometrioid adenocarcinoma. IGF-1Ec expression was also high in the presence of tumoral necrosis. Furthermore, there was a significant correlation between the histological differentiation and the sum of staining intensity and the number of IGF-1Ec immunopositive cells in endometrial carcinoma. There was a moderate negative correlation between co-expression of IGF-1Ec and PTEN, for both the number of immunopositive cells (P=0.006, ρ=-0.343) and the sum of staining (scores and intensity; P=0.006, ρ=-0.343). Furthermore, there was a positive correlation between the sum of staining (scores and intensity) and co-expression of IGF-1Ec and survivin (P=0.043, ρ=0.225). However, there was no association between concomitant expression of IGF-1Ec and p53. These results emphasized the importance of IGF-1Ec expression during development of non-estrogen dependent endometrial adenocarcinoma. IGF-1Ec and PTEN may function opposingly during endometrial carcinogenesis. By contrast, IGF-1Ec and survivin may share common molecular pathways and may promote, in parallel, tumoral development.

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Expression of anti‑apoptotic protein survivin in human endometrial carcinoma: Clinical and pathological associations as a separate factor and in combination with concomitant PTEN and p53 expression

Cited by 5 publications

References 71 publications

MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis

MRI-based radiomics and ADC values are related to recurrence of endometrial carcinoma: a preliminary analysis

Significance of combined TGF‑β1 and survivin expression on the prognosis of patients with triple‑negative breast cancer

Immunohistochemical expression of insulin‑like growth factor‑1Ec in primary endometrial carcinoma: Association with PTEN, p53 and survivin expression

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