Expression of anti-Müllerian hormone mRNA during gonadal and follicular development in the brushtail possum (Trichosurus vulpecula)

Juengel, Jennifer L.; Whale, Lisa J.; Wylde, Katherine A.; Greenwood, Penny; McNatty, Kenneth P.; Eckery, Douglas C.

doi:10.1071/rd02027

Cited by 20 publications

(20 citation statements)

References 33 publications

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“…The expression profiles of MIS in the adult human and monkey ovary are identical and comparable to that observed previously in other species (Bezard et al 1987, Uneo et al 1989a, Baarends et al 1995, Juengel et al 2002, Visser et al 2006. Table 1 compares the results of different studies on cellular localization of MIS transcripts and protein in the adult cycling ovary.…”

Section: Discussionsupporting

confidence: 59%

“…While in this study and that reported by Stubbs et al (2005), MIS is detected in the granulosa cells of primordial follicles until ovulatory follicles; weak, but specific MIS transcripts and protein are detectable in the stromal cells. Contrasting these observations, previous studies have reported the absence of MIS in the primordial follicles and stroma (Bezard et al 1987, Uneo et al 1989a, Baarends et al 1995, Juengel et al 2002. To our knowledge, granulosa cells of the primordial follicles and the ovarian stroma as sites of MIS synthesis have not been reported earlier.…”

Section: Discussioncontrasting

confidence: 52%

“…MIS mRNA was detected at high levels in a small population of oocytes/oogonia of fetal human ovary; the frequency was estimated to be w1-3%. These findings are novel and surprising since MIS has not been reported in the germ line of other mammalian species (Bezard et al 1987, Uneo et al 1989a,b, Hirobe et al 1992, Durlinger et al 2002a, Juengel et al 2002. A striking feature of the MIS-positive oocytes was the absence of its association with the granulosa cells.…”

Section: Discussionmentioning

confidence: 69%

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Developmental expression and cellular distribution of Müllerian inhibiting substance in the primate ovary

Modi¹,

Bhartiya²,

Puri³

2006

Reproduction

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Ovarian follicle formation during development and follicle maturation in adulthood are crucial determinants of female fertility and disruptions in these processes may result in subfertility or infertility. Among the several factors that are involved in ovarian physiology, Mü llerian inhibiting substance (MIS) also known as anti-Mü llerian hormone has emerged as an important marker to predict the follicle reserve. However, the roles of MIS in human ovarian physiology are unknown. To gain an insight into the potential roles of MIS in human ovarian differentiation during development and its regulation in adulthood, the expression profiles of MIS mRNA in the developing and adult human and monkey ovaries was examined by in situ hybridization. The results revealed that in the fetal human ovaries, MIS is specifically expressed at low levels in the granulosa cells of the developing primordial follicles; a small subset (w2-3%) of oocytes express high amounts of MIS. In the adult human and monkey ovary, MIS mRNA is expressed at low levels in the primordial follicles, maximally in the primary and secondary follicles, and the expression is downregulated in the antral and atetric follicles. MIS expression is extinguished in the granulosa cells only after ovulation. These observations strongly favor the regulatory roles of MIS in folliculogenesis. MIS in the primate ovary may exert its effect during the primordial follicle formation to the terminal granulosa cell differentiation. The presence of MIS in a small subset of oocytes in the fetal ovary further points towards its additional role during fetal oocyte development.

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Section: Discussionsupporting

confidence: 59%

Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 69%

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Developmental expression and cellular distribution of Müllerian inhibiting substance in the primate ovary

Modi¹,

Bhartiya²,

Puri³

2006

Reproduction

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“…Expression of AMH increases as the follicle develops through the preantral and small antral stages in humans (Weenen et al 2004). Similar patterns occur in non-human primates (Modi et al 2006), mice (Gruijters et al 2003), rats (Ueno et al 1989, Hirobe et al 1994, Baarends et al 1995, Siberian hamsters (Shahed & Young 2013), cows (Monniaux et al 2012), goats (Monniaux et al 2012, Rocha et al 2016, sheep (Bezard et al 1987) and brushtail possums (Juengel et al 2002). AMH expression declines as follicles progress through the large antral stage of folliculogenesis, with little AMH being produced in preovulatory follicles (Ueno et al 1989, Weenen et al 2004, Jeppesen et al 2013.…”

Section: Anti-müllerian Hormone Expression In the Ovarymentioning

confidence: 65%

A putative role for anti-Müllerian hormone (AMH) in optimising ovarian reserve expenditure

Pankhurst

2017

Journal of Endocrinology

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The mammalian ovary has a finite supply of oocytes, which are contained within primordial follicles where they are arrested in a dormant state. The number of primordial follicles in the ovary at puberty is highly variable between females of the same species. Females that enter puberty with a small ovarian reserve are at risk of a shorter reproductive lifespan, as their ovarian reserve is expected to be depleted faster. One of the roles of anti-Müllerian hormone (AMH) is to inhibit primordial follicle activation, which slows the rate at which the ovarian reserve is depleted. A simple interpretation is that the function of AMH is to conserve ovarian reserve. However, the females with the lowest ovarian reserve and the greatest risk of early reserve depletion have the lowest levels of AMH. In contrast, AMH apparently strongly inhibits primordial follicle activation in females with ample ovarian reserve, for reasons that remain unexplained. The rate of primordial follicle activation determines the size of the developing follicle pool, which in turn, determines how many oocytes are available to be selected for ovulation. This review discusses the evidence that AMH regulates the size of the developing follicle pool by altering the rate of primordial follicle activation in a context-dependent manner. The expression patterns of AMH across life are also consistent with changing requirements for primordial follicle activation in the ageing ovary. A potential role of AMH in the fertility of ageing females is proposed herein.

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“…AMH is synthesised in the gonads of all vertebrate species examined to date, including fish (Western et al 1999, Halm et al 2007, amphibians (Kodama et al 2015), birds (Smith et al 1999, Nishikimi et al 2000, reptiles (Western et al 1999, Shoemaker et al 2007, marsupials (Juengel et al 2002, Pask et al 2004 and eutherian mammals (Josso 1973, Meyers-Wallen et al 1987, Kuroda et al 1990. In fish that do not have Müllerian ducts, AMH regulates the proliferation of germ cells in both sexes (Morinaga et al 2007).…”

Section: Amh Is a Gonadal Cytokinementioning

confidence: 99%

Anti-Müllerian hormone is a gonadal cytokine with two circulating forms and cryptic actions

McLennan¹,

Pankhurst²

2015

Journal of Endocrinology

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Anti-Mü llerian hormone (AMH) is a multi-faceted gonadal cytokine. It is present in all vertebrates with its original function in phylogeny being as a regulator of germ cells in both sexes, and as a prime inducer of the male phenotype. Its ancient functions appear to be broadly conserved in mammals, but with this being obscured by its overt role in triggering the regression of the Mü llerian ducts in male embryos. Sertoli and ovarian follicular cells primarily release AMH as a prohormone (proAMH), which forms a stable complex (AMH N,C ) after cleavage by subtilisin/kexin-type proprotein convertases or serine proteinases. Circulating AMH is a mixture of proAMH and AMH N,C , suggesting that proAMH is activated within the gonads and putatively by its endocrine target-cells. The gonadal expression of the cleavage enzymes is subject to complex regulation, and the preliminary data suggest that this influences the relative proportions of proAMH and AMH N,C in the circulation. AMH shares an intracellular pathway with the bone morphogenetic protein (BMP) and growth differentiation factor (GDF) ligands. AMH is male specific during the initial stage of development, and theoretically should produce male biases throughout the body by adding a male-specific amplification of BMP/GDF signalling. Consistent with this, some of the male biases in neuron number and the non-sexual behaviours of mice are dependent on AMH. After puberty, circulating levels of AMH are similar in men and women. Putatively, the function of AMH in adulthood maybe to add a gonadal influence to BMP/GDF-regulated homeostasis.

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Expression of anti-Müllerian hormone mRNA during gonadal and follicular development in the brushtail possum (Trichosurus vulpecula)

Cited by 20 publications

References 33 publications

Developmental expression and cellular distribution of Müllerian inhibiting substance in the primate ovary

Developmental expression and cellular distribution of Müllerian inhibiting substance in the primate ovary

A putative role for anti-Müllerian hormone (AMH) in optimising ovarian reserve expenditure

Anti-Müllerian hormone is a gonadal cytokine with two circulating forms and cryptic actions

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