Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa

Abstract

HNP 1-3 and lysozyme are expressed in surface enterocytes of mucosa with active IBD and they may play an important role in intestinal host defence against luminal microorganisms.

Identification of macrophage migration inhibitory factor and human neutrophil peptides 1–3 as potential biomarkers for gastric cancer

“…Human neutrophil peptides 1 -3 are members of the a-defensin family of antimicrobial peptides reported to be expressed by neutrophils and epithelial cells under certain conditions (Cunliffe et al, 2002). Human neutrophil peptides 1 -3 have been shown to be elevated in either tumour tissue or serum from patients with a range of cancer types (Müller et al, 2002;Lundy et al, 2004;Albrethsen et al, 2005;Melle et al, 2005), and we now extend this observation to gastric cancer.…”

“…Human neutrophil peptides 1 -3 have been shown to be elevated in either tumour tissue or serum from patients with a range of cancer types (Müller et al, 2002;Lundy et al, 2004;Albrethsen et al, 2005;Melle et al, 2005), and we now extend this observation to gastric cancer. Human neutrophil peptides 1 -3 are also elevated by inflammation, for example, inflammatory bowel disease (Cunliffe et al, 2002) and so may lack specificity as tumour Figure 3 Partial least squares regression analysis using all peaks from CM10 and IMAC SELDI serum profiles of 50 gastric cancer patients (filled symbols) and 29 non-cancer controls (hollow symbols). Figure 4 The images of the duplicate MIF antibody spots on the cytokine array for pooled control serum, pooled early (stages I -II) and pooled late (stages III -IV) sera.…”

Cellular Response to Trypanosoma cruzi Infection Induces Secretion of Defensin α-1, Which Damages the Flagellum, Neutralizes Trypanosome Motility, and Inhibits Infection

“…Six human ␣-defensins have been identified (19), including ␣-1, ␣-2, ␣-3, ␣-4, HD5, and HD6. Human ␣-defensins are expressed in neutrophils, Paneth cells, certain macrophage populations, and epithelial cells of multiple tissues in the body (13,14,16,20). ␣-Defensins are also engaged in cross talk with cells of the immune system.…”

“…Defensins are small peptides that are produced particularly by leukocytes and epithelial cells as well as by other cells and have important effector roles in innate immunity against some microbes (13)(14)(15)(16)(17)(18). Six human ␣-defensins have been identified (19), including ␣-1, ␣-2, ␣-3, ␣-4, HD5, and HD6.…”

Defensins in Ulcerative Colitis

“…The expression of HNP-1, -2, and -3 mRNA is correlated with the levels of NO and MDA in the inflamed mucosa in UC patients, the induction of HNP-1, -2, and -3 is involved in the process of inflammation and damage of UC. HNP-1, -2, and -3, NO and MDA might have synergistic effects on colonic inflammation (Cunliffe et al, 2002(Cunliffe et al, , 2003. These HNPs are also significantly increased in sera of IBD patients compared with controls, and being significantly correlated with CD activity index, peripheral white blood cell counts, serum CRP values and TNF-levels (Yamaguchi et al, 2009).…”